Results 21 to 30 of about 27,199 (232)

Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice [PDF]

The Journal of Immunology, 2001
Abstract The chemokine receptors CCR2 and CCR5 play important roles in the recruitment of monocytes/macrophages and T cells. To better understand the role of both receptors in murine models of inflammatory diseases and to recognize potential problems when correlating these data to humans, we have generated mAbs against murine CCR2 and
M, Mack, J, Cihak, C, Simonis, B, Luckow, A E, Proudfoot, J, Plachý , H, Brühl, M, Frink, H J, Anders, V, Vielhauer, J, Pfirstinger, M, Stangassinger, D, Schlöndorff   +12 more
openaire   +2 more sources

Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue ...
Reza Akbarzadeh, Reza Akbarzadeh, Christianna Czyz, Sarah-Yasmin Thomsen, Paul Schilf, Sripriya Murthy, Christian D. Sadik, Peter König   +7 more
doaj   +1 more source

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.

PLoS ONE, 2012
BackgroundLeukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis ...
Silvia Volpe, Elisabetta Cameroni, Barbara Moepps, Sylvia Thelen, Tiziana Apuzzo, Marcus Thelen   +5 more
doaj   +1 more source

α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

Pharmacological Research, 2023
We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing.
Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak   +4 more
doaj   +1 more source

CCR2 regulates the uptake of bone marrow-derived fibroblasts in renal fibrosis. [PDF]

PLoS ONE, 2013
Recent studies have shown that bone marrow-derived fibroblasts contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment of bone marrow-derived fibroblasts into the kidney are ...
Yunfeng Xia, Mark L Entman, Yanlin Wang
doaj   +1 more source

Differential expression of chemokine receptors on monocytes in TB and HIV S

Heliyon, 2023
In the present study, we defined multiple chemokine receptors expressed by classical, intermediate and non-classical monocyte subsets in TB, HIV and TB/HIV co-infection and associate it with the perturbation of monocyte subsets due to the diseases ...
Wegene Tamene, Vincent C. Marconi, Meseret Abebe, Liya Wassie, Yohannes Belay, Amha Kebede, Ulrich Sack, Rawleigh Howe   +7 more
doaj   +1 more source

Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction [PDF]

Genes & Immunity, 2001
Our objective was to examine the association between myocardial infarction (MI) and two DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 bp deletion, (Delta)ccr5), defining if these polymorphisms influence the age for the onset of MI. A total of 214 patients with an age at the first MI episode
P, González, R, Alvarez, A, Batalla, J R, Reguero, V, Alvarez, A, Astudillo, G I, Cubero, A, Cortina, E, Coto   +8 more
openaire   +2 more sources

Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 2010
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis.
Denise Silveira-Lemos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Adriano Luiz Souza-Soares, Pollyanna Castro-Silva, Matheus Fernandes Costa-Silva, Pedro Henrique Gazzinelli Guimarães, Helena Barbosa Ferraz, Lúcia Alves Oliveira-Fraga, Mauro Martins Teixeira, Rodrigo Corrêa-Oliveira   +10 more
doaj   +1 more source

Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria [PDF]

Infection and Immunity, 2003
ABSTRACTInfection withPlasmodium bergheiANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8+T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+T-cell ...
Belnoue, E, Costa, FT, Vigario, AM, Voza, T, Gonnet, F, Landau, I, van Rooijen, N., Mack, M, Kuziel, WA, Renia, L   +9 more
openaire   +3 more sources

Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells.
S.M. Mohaddes Ardebili
doaj