Results 21 to 30 of about 27,078 (238)

Bidirectional Action of Cenicriviroc, a CCR2/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy

Frontiers in Immunology, 2020
Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their ...
Klaudia Kwiatkowski, Katarzyna Pawlik, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika   +5 more
doaj   +1 more source

Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4. [PDF]

PLoS ONE, 2015
Inflammatory (classical) monocytes residing in the bone marrow must enter the bloodstream in order to combat microbe infection. These monocytes express high levels of CCR2, a chemokine receptor whose activation is required for them to exit the bone ...
Hosung Jung, Divakar S Mithal, Jeong Eun Park, Richard J Miller   +3 more
doaj   +1 more source

Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria [PDF]

Infection and Immunity, 2003
ABSTRACTInfection withPlasmodium bergheiANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8+T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+T-cell ...
Belnoue, E, Costa, FT, Vigario, AM, Voza, T, Gonnet, F, Landau, I, van Rooijen, N., Mack, M, Kuziel, WA, Renia, L   +9 more
openaire   +3 more sources

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.

PLoS ONE, 2012
BackgroundLeukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis ...
Silvia Volpe, Elisabetta Cameroni, Barbara Moepps, Sylvia Thelen, Tiziana Apuzzo, Marcus Thelen   +5 more
doaj   +1 more source

Differential expression of chemokine receptors on monocytes in TB and HIV S

Heliyon, 2023
In the present study, we defined multiple chemokine receptors expressed by classical, intermediate and non-classical monocyte subsets in TB, HIV and TB/HIV co-infection and associate it with the perturbation of monocyte subsets due to the diseases ...
Wegene Tamene, Vincent C. Marconi, Meseret Abebe, Liya Wassie, Yohannes Belay, Amha Kebede, Ulrich Sack, Rawleigh Howe   +7 more
doaj   +1 more source

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease [PDF]

Frontiers in Immunology, 2022
Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to ...
Shaoping She, Liying Ren, Pu Chen, Mingyang Wang, Dongbo Chen, Ying Wang, Hongsong Chen   +6 more
openaire   +3 more sources

α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

Pharmacological Research, 2023
We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing.
Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak   +4 more
doaj   +1 more source

Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue ...
Reza Akbarzadeh, Reza Akbarzadeh, Christianna Czyz, Sarah-Yasmin Thomsen, Paul Schilf, Sripriya Murthy, Christian D. Sadik, Peter König   +7 more
doaj   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

CCR2 regulates the uptake of bone marrow-derived fibroblasts in renal fibrosis. [PDF]

PLoS ONE, 2013
Recent studies have shown that bone marrow-derived fibroblasts contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment of bone marrow-derived fibroblasts into the kidney are ...
Yunfeng Xia, Mark L Entman, Yanlin Wang
doaj   +1 more source