Results 31 to 40 of about 27,078 (238)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis [PDF]

Proceedings of the National Academy of Sciences, 2012
Osteoarthritis is one of the leading causes of chronic pain, but almost nothing is known about the mechanisms and molecules that mediate osteoarthritis-associated joint pain. Consequently, treatment options remain inadequate and joint replacement is often inevitable.
Rachel E, Miller, Phuong B, Tran, Rosalina, Das, Nayereh, Ghoreishi-Haack, Dongjun, Ren, Richard J, Miller, Anne-Marie, Malfait   +6 more
openaire   +2 more sources

The chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis [PDF]

Immunology Letters, 2017
Thymic dendritic cells (DC) play a role in central tolerance. Three thymic DC subtypes have been described: plasmacytoid DC (pDC) and two conventional DC (cDC), CD8α+ Sirpα- DC and Sirpα+ CD8α- cDC. Both pDC and Sirpα+ cDC can take up antigen in periphery and migrate into the thymus in response to chemokine signaling via CCR9 and CCR2 respectively ...
Cédile, Oriane, Østerby Jørgensen, Line, Frank, Ida, Wlodarczyk, Agnieszka, Owens, Trevor; id_orcid 0000-0001-9315-6036   +4 more
openaire   +3 more sources

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

, 2023
Abstract By driving monocyte chemotaxis, the chemokine receptor CCR2 shapes inflammatory responses and the formation of tumor microenvironments. This makes it a promising target in inflammation and immuno-oncology; however, despite extensive efforts, there are no FDA-approved CCR2-targeting therapeutics.
John R.D. Dawson, Grant M. Wadman, Penglie Zhang, Andrew Tebben, Percy H. Carter, Siyi Gu, Thomas Shroka, Leire Borrega-Roman, Catherina L. Salanga, Tracy M. Handel, Irina Kufareva   +10 more
openaire   +2 more sources

Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.

PLoS ONE, 2010
BackgroundMonocyte subpopulations distinguished by differential expression of chemokine receptors CCR2 and CX3CR1 are difficult to track in vivo, partly due to lack of CCR2 reagents.Methodology/principal findingsWe created CCR2-red fluorescent protein ...
Noah Saederup, Astrid E Cardona, Kelsey Croft, Makiko Mizutani, Anne C Cotleur, Chia-Lin Tsou, Richard M Ransohoff, Israel F Charo   +7 more
doaj   +1 more source

Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 2010
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis.
Denise Silveira-Lemos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Adriano Luiz Souza-Soares, Pollyanna Castro-Silva, Matheus Fernandes Costa-Silva, Pedro Henrique Gazzinelli Guimarães, Helena Barbosa Ferraz, Lúcia Alves Oliveira-Fraga, Mauro Martins Teixeira, Rodrigo Corrêa-Oliveira   +10 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis

mBio
Infection by Mycobacterium tuberculosis (Mtb) continues to cause more than 1 million deaths annually, due to pathogen persistence in lung macrophages and dendritic cells derived from blood monocytes.
Alexander Mohapatra, Brian A. Norris, Zachary Howard, Joel D. Ernst   +3 more
doaj   +1 more source

Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE

Journal of Neuroinflammation, 2007
Background The CC chemokine receptors CCR1, CCR2 and CCR5 are critical for the recruitment of mononuclear phagocytes to the central nervous system (CNS) in multiple sclerosis (MS) and other neuroinflammatory diseases.
Ericsson-Dahlstrand Anders, Olsson Tomas, Nilsson Maria, Wallström Erik, Lassmann Hans, Berg Anna-Lena, Eltayeb Sana, Sunnemark Dan   +7 more
doaj   +1 more source