Results 1 to 10 of about 37,341 (166)
Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?
Frontiers in Immunology, 2021 CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory functions, prompting the development of CCR2 antagonists to dampen unwanted immune responses in inflammatory and autoimmune diseases.
Haijia Yu, Yifan Zhan, Yu Haijia
exaly +3 more sources
Roles of CCL2-CCR2 Axis in the Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2021 Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such
Suguru Kadomoto +2 more
exaly +3 more sources
Modulation of CCR2/CCL2 molecular axis in the expansion and rupture of abdominal aortic aneurysms [PDF]
Frontiers in Cardiovascular MedicineThe CCR2/CCL2 molecular axis is a critical mediator of abdominal aortic aneurysm (AAA) pathogenesis. It has been demonstrated to drive chronic inflammation, extracellular matrix degradation, and vascular remodeling through the recruitment and activation ...
Ryan Wahidi +11 more
doaj +2 more sources
Hydrogen relieves neuropathic pain in diabetic rats by inhibiting mcp1 and ccr2 expressions [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 We aimed to explore the mechanism for hydrogen in the treatment of neuropathic pain in diabetic rats. Eight-week-old male SD rats were randomly divided into control, model and hydrogen treatment groups.
Pin WANG +5 more
doaj +1 more source
Silencing of CCR2 in myocarditis [PDF]
European Heart Journal, 2014 Myocarditis is characterized by inflammatory cell infiltration of the heart and subsequent deterioration of cardiac function. Monocytes are the most prominent population of accumulating leucocytes. We investigated whether in vivo administration of nanoparticle-encapsulated siRNA targeting chemokine (C-C motif) receptor 2 (CCR2)-a chemokine receptor ...
Leuschner, Florian +21 more
openaire +4 more sources
Frontiers in Bioscience-Landmark, 2023 Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation.
Chao Feng +5 more
doaj +1 more source
Journal of Contemporary Medicine, 2022 Background: Familial Mediterranean Fever (FMF) is an autoinflammatory disease and may express as various clinical findings. Chemokines are crucial elements of the inflammatory process.
Nadir Koçak, Şenol Çitli
doaj +1 more source
CCL2/CCR2 signaling in cancer pathogenesis [PDF]
Cell Communication and Signaling, 2020 AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao +2 more
openaire +3 more sources
CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]
Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015 The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy +2 more
openaire +4 more sources
Targeting the CCL2–CCR2 axis for atheroprotection
European Heart Journal, 2022 AbstractDecades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for lowering residual vascular risk.
Marios K Georgakis +4 more
openaire +5 more sources