Results 1 to 10 of about 39,013 (119)

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

Frontiers in Immunology, 2021
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory functions, prompting the development of CCR2 antagonists to dampen unwanted immune responses in inflammatory and autoimmune diseases.
Yifan Zhan, Haijia Yu
exaly   +3 more sources

Hydrogen relieves neuropathic pain in diabetic rats by inhibiting mcp1 and ccr2 expressions [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
We aimed to explore the mechanism for hydrogen in the treatment of neuropathic pain in diabetic rats. Eight-week-old male SD rats were randomly divided into control, model and hydrogen treatment groups.
Pin WANG, Lanying YOU, Qian LI, Hao WANG, Yun LONG, Wei CHEN   +5 more
doaj   +1 more source

Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity

Experimed, 2023
Objective: Approximately 80% of people with coronavirus disease 2019 (COVID-19) are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization.
Selen Zeliha Mart Kömürcü, Şeydanur Doğan, Ebru Kaya, Sevim Yavaş, Serkan Doğan, Utku Murat Kalafat, Hayriye Şentürk Çiftçi, Selçuk Daşdemir   +7 more
doaj   +1 more source

GLUT1 Mediates the Metabolic Reprogramming and Inflammation of CCR2$^+$ Monocytes/Macrophages from Patients with DCM

Frontiers in Bioscience-Landmark, 2023
Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation.
Chao Feng, Hantao Jiang, Xueyuan Yang, Hongliang Cong, Lan Li, Jinping Feng   +5 more
doaj   +1 more source

An Alternative Perspective to the FMF Clinic: MCP-1 (A-2518G) and CCR2 (G190A) Polymorphisms and MCP1 Expression

Journal of Contemporary Medicine, 2022
Background: Familial Mediterranean Fever (FMF) is an autoinflammatory disease and may express as various clinical findings. Chemokines are crucial elements of the inflammatory process.
Nadir Koçak, Şenol Çitli
doaj   +1 more source

CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis

Biomolecules, 2023
In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has been shown to play an important role in bone physiology.
Helen Willcockson, Huseyin Ozkan, José Valdés-Fernández, Liubov Arbeeva, Esra Mucahit, Layla Musawwir, Lola B. Hooper, Froilán Granero-Moltó, Felipe Prósper, Lara Longobardi   +9 more
doaj   +1 more source

Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression

Scientific Reports, 2021
Macrophages expressing C–C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients.
Wataru Shiraishi, Ryo Yamasaki, Yu Hashimoto, Senri Ko, Yuko Kobayakawa, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira   +7 more
doaj   +1 more source

Pharmacological Inhibition of CCR2 Signaling Exacerbates Exercise-Induced Inflammation Independently of Neutrophil Infiltration and Oxidative Stress

Immuno, 2021
Although exercise-induced humoral factors known as exerkines benefit systemic health, the role of most exerkines has not been investigated. Monocyte chemoattractant protein-1 (MCP-1) is a representative chemokine whose circulating concentrations increase
Takaki Tominaga, Jiapeng Huang, Katsuhiko Suzuki   +2 more
doaj   +1 more source

Possible association between expression of chemokine receptor-2 (CCR2) and amyotrophic lateral sclerosis (ALS) patients of North India. [PDF]

PLoS ONE, 2012
BACKGROUND AND OBJECTIVES: We earlier reported elevated chemokine ligand-2 (CCL2) in Indian amyotrophic lateral sclerosis (ALS) patients. We now analysed chemokine receptor-2 (CCR2), the receptor of CCL2, in these ALS patients.
Pawan K Gupta, Sudesh Prabhakar, Neel K Sharma, Akshay Anand   +3 more
doaj   +1 more source

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

eLife, 2019
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil, Patrick B Rapuano, Uchenna Ikediobi, Rebecca Leibowitz, Sameet Mehta, Ayse K Coskun, J Zachary Porterfield, Teagan D Lampkin, Vincent C Marconi, David Rimland, Bruce D Walker, Steven Deeks, Richard E Sutton   +12 more
doaj   +1 more source