Results 1 to 10 of about 37,511 (242)

Modulation of CCR2/CCL2 molecular axis in the expansion and rupture of abdominal aortic aneurysms [PDF]

Frontiers in Cardiovascular Medicine
The CCR2/CCL2 molecular axis is a critical mediator of abdominal aortic aneurysm (AAA) pathogenesis. It has been demonstrated to drive chronic inflammation, extracellular matrix degradation, and vascular remodeling through the recruitment and activation ...
Ryan Wahidi, Ryan Wahidi, Santiago Elizondo-Benedetto, Ryan Catlett, Bera Koklu, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed   +11 more
doaj   +2 more sources

Hydrogen relieves neuropathic pain in diabetic rats by inhibiting mcp1 and ccr2 expressions [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
We aimed to explore the mechanism for hydrogen in the treatment of neuropathic pain in diabetic rats. Eight-week-old male SD rats were randomly divided into control, model and hydrogen treatment groups.
Pin WANG, Lanying YOU, Qian LI, Hao WANG, Yun LONG, Wei CHEN   +5 more
doaj   +1 more source

Silencing of CCR2 in myocarditis [PDF]

European Heart Journal, 2014
Myocarditis is characterized by inflammatory cell infiltration of the heart and subsequent deterioration of cardiac function. Monocytes are the most prominent population of accumulating leucocytes. We investigated whether in vivo administration of nanoparticle-encapsulated siRNA targeting chemokine (C-C motif) receptor 2 (CCR2)-a chemokine receptor ...
Leuschner, Florian, Courties, Gabriel, Dutta, Partha, Mortensen, Luke, Gorbatov, Rostic, Sena, Brena, Novobrantseva, Tatiana, Borodovsky, Anna, Fitzgerald, Kevin, Koteliansky, Victor, Iwamoto, Yoshiko, Bohlender, Marina, Meyer, Soeren, Lasitschka, Felix, Meder, Benjamin, Katus, Hugo, Lin, Charles, Libby, Peter, Swirski, Filip, Anderson, Daniel, Weissleder, Ralph, Nahrendorf, Matthias   +21 more
openaire   +4 more sources

GLUT1 Mediates the Metabolic Reprogramming and Inflammation of CCR2$^+$ Monocytes/Macrophages from Patients with DCM

Frontiers in Bioscience-Landmark, 2023
Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation.
Chao Feng, Hantao Jiang, Xueyuan Yang, Hongliang Cong, Lan Li, Jinping Feng   +5 more
doaj   +1 more source

An Alternative Perspective to the FMF Clinic: MCP-1 (A-2518G) and CCR2 (G190A) Polymorphisms and MCP1 Expression

Journal of Contemporary Medicine, 2022
Background: Familial Mediterranean Fever (FMF) is an autoinflammatory disease and may express as various clinical findings. Chemokines are crucial elements of the inflammatory process.
Nadir Koçak, Şenol Çitli
doaj   +1 more source

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

Frontiers in Immunology, 2021
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory functions, prompting the development of CCR2 antagonists to dampen unwanted immune responses in inflammatory and autoimmune diseases.
Liyang Fei, Xiaochen Ren, Haijia Yu, Yifan Zhan   +3 more
doaj   +1 more source

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

eLife, 2019
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil, Patrick B Rapuano, Uchenna Ikediobi, Rebecca Leibowitz, Sameet Mehta, Ayse K Coskun, J Zachary Porterfield, Teagan D Lampkin, Vincent C Marconi, David Rimland, Bruce D Walker, Steven Deeks, Richard E Sutton   +12 more
doaj   +1 more source

Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression

Scientific Reports, 2021
Macrophages expressing C–C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients.
Wataru Shiraishi, Ryo Yamasaki, Yu Hashimoto, Senri Ko, Yuko Kobayakawa, Noriko Isobe, Takuya Matsushita, Jun-ichi Kira   +7 more
doaj   +1 more source

CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis

Biomolecules, 2023
In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has been shown to play an important role in bone physiology.
Helen Willcockson, Huseyin Ozkan, José Valdés-Fernández, Liubov Arbeeva, Esra Mucahit, Layla Musawwir, Lola B. Hooper, Froilán Granero-Moltó, Felipe Prósper, Lara Longobardi   +9 more
doaj   +1 more source

Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice. [PDF]

PLoS ONE, 2016
CCR2 is a chemokine receptor expressed on the surface of blood leukocytes, particularly «Ly6Chi» inflammatory monocytes and microglia. Signaling through this receptor is thought to influence the immune activity of microglia as well as monocytes egress ...
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin   +4 more
doaj   +1 more source