Results 41 to 50 of about 45,468 (163)

Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis. [PDF]

PLoS ONE, 2012
The CCL2 CCR2 axis is likely to contributes to the development and progression of cancer diseases by two major mechanisms; autocrine effect of CCL2 as a survival/growth factor for CCR2+ cancer cells and, the attraction of CCR2+ CX₃CR1+tumor associated ...
Liat Izhak, Gizi Wildbaum, Steffen Jung, Avi Stein, Yuval Shaked, Nathan Karin   +5 more
doaj   +1 more source

Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway

Journal of Neuroinflammation, 2022
Background Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients with subarachnoid hemorrhage (SAH). We investigated the role of C–C motif chemokine receptor 2 (CCR2) in SAH.
Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li   +9 more
doaj   +1 more source

Figure 7: CCR2

, 2019
The model integrates the findings from the current study with prior work (5,7,9,10). During the early compensated phase of pressure overload, there is myocardial up-regulation of chemokine ligands for CCR2 (CCL2, CCL7, CCL12) and innate immune cell ...
Sumanth D. Prabhu (549964), Bindiya Patel (3709933), Mohamed Ameen Ismahil (3709942), Matthias Mack (148002), Shyam S. Bansal (3709936), Tariq Hamid (3709939), Gregg Rokosh (315012)   +6 more
core   +1 more source

PCR verification of CCR2 genotype.

, 2014
Representative digital images of ethidium bromide-stained agarose gels of resolved tail snip genomic DNA (A and B) and splenocyte cDNA (C and D) demonstrate mouse CCR2 genotype.
Nejla Yosef (535494), Chetan Lakshmana Reddy (535495), Ailing Huang (535496), Sharon C. Chiang (535497), Hafiza Rahman Tithi (535498), Furong Yuan (433050), Eroboghene E. Ubogu (535499)   +6 more
core   +1 more source

CCR2 receptor antagonist (CCR2 RA-) administration reversed existing nociceptive behavior

, 2011
Copyright information:Taken from "Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors"http://www.molecularpain ...
Patrick E Monahan (61051), Matthew S Ripsch (61053), David M Chan (61052), Fletcher A White (61054), Richard J Miller (61046), Baolin Li (61050), Chafiq Hamdouchi (61049), Sonia Bhangoo (61044), Dongjun Ren (61045), Kenneth J Henry (61047), Jayana Lineswala (61048)   +10 more
core   +1 more source

A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

Journal of Neuroinflammation, 2018
Background A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing ...
Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio   +3 more
doaj   +1 more source

Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma

Cancer Cell International, 2022
Background Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal.
Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han, Lixin Wei   +8 more
doaj   +1 more source

CCR2 Promotes Hepatic Fibrosis in Mice

, 2009
Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of CCR2, the receptor for monocyte chemoattractant protein (MCP)-1, MCP-2,
Schwabe, R.F., Seki, E., Brenner, D.A., Miyai, K., Inokuchi, S., De Minicis, S., van Rooijen, N., Taura, K.   +7 more
core   +1 more source

Determination of fate of CCR2 downregulation on monocytes from Ficoll.

, 2013
CCR2 expression was assessed after Ficoll isolation of untagged and tagged-CCR2 monocytes. Internalization of the complex was examined from one single layer of Z stacks by confocal microscopy. The results of a representative experiment are shown: a) CCR2
M. Angels Ortiz (330439), Carlos Zamora (330437), Elisabet Cantó (330435), Juan C. Nieto (330433), Cándido Juárez (330440), Silvia Vidal (4659)   +5 more
core   +1 more source

CCR2−/− mice display impaired development of CCR2+ primary tumors that become non-metastatic.

, 2013
(A) Six CCR2+/+ C57BL/6 mice (WT) and six CCR2−/− C57BL/6 mice were administered with 7×106 TRAMP C1-luc cells. Imaging of primary tumor was done on day 60, as recorded by the CCD camera (IVIS).
Avi Stein (334904), Liat Izhak (334902), Yuval Shaked (37384), Gizi Wildbaum (334903), Steffen Jung (192792), Nathan Karin (334905)   +5 more
core   +1 more source