Results 1 to 10 of about 100,029 (302)
A role for CCL2 in both tumor progression and immunosurveillance [PDF]
OncoImmunology, 2013 The chemokine CCL2, which is best known for its chemotactic functions, is expressed not only by immune cells, but also by several types of malignant and stromal cells. CCL2 has been shown to exert both pro- and anti-tumor effects. However, recent results demonstrate a main role for CCL2 in tumor progression and metastasis, suggesting that this ...
Deborah A Knight +2 more
exaly +8 more sources
Role of CCL2/MCP-1 in Islet Transplantation
Cell Transplantation, 2010 High levels of donor-derived CCL2 have been associated with poor islet allograft outcome in patients with type 1 diabetes. The aim of our work was to determine whether CCL2 secreted by the islet has independent proinflammatory effects that influence ...
Raffaella Melzi +10 more
doaj +7 more sources
Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]
Clinical and Translational Allergy, 2020 AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur +7 more
openaire +5 more sources
Roles of CCL2-CCR2 Axis in the Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2021 Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such
Suguru Kadomoto +2 more
exaly +3 more sources
Cancer Biology & Therapy, 2023 Background Oral tongue cancer is an extremely malignant tumor with high rate of lymphatic metastasis. Little is known about its invasion and metastasis mechanisms so far. Methods To clarify the main role of CCL2 in tongue cancer progression, we performed
Yuqing Dong +6 more
doaj +1 more source
The Vascular Circadian Clock in Chronic Kidney Disease
Cells, 2021 Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular ...
Søren Egstrand +3 more
doaj +1 more source
Сибирский онкологический журнал, 2021 Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement ...
S. O. Gening +7 more
doaj +1 more source
Molecular markers of cardiac fibrosis after myocardial infarction
Фундаментальная и клиническая медицина, 2022 Aim. To perform a screening for molecular markers of cardiac fibrosis upon myocardial infarction.Materials and Methods. We carried out echocardiography-guided endomyocardial biopsy of affected and intact interventricular septum segments of 7 patients ...
O. L. Barbarash +8 more
doaj +1 more source
Identification of a novel regulatory pathway for PPARα by RNA-seq characterization of the endothelial cell lipid peroxidative injury transcriptome [PDF]
Open Biology, 2019 Endothelial dysfunction caused by endothelial cell injuries is the initiating factor for atherosclerosis (AS), and lipid peroxidative injury is one of a dominant factor for AS pathogenesis.
Fangfang Dou +6 more
doaj +1 more source
CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]
Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015 The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy +2 more
openaire +4 more sources