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CCL2/CCR2 signaling in cancer pathogenesis [PDF]
Cell Communication and Signaling, 2020 Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Q. Hao, J. Vadgama, Piwen Wang
semanticscholar +4 more sources
Roles of CCL2-CCR2 Axis in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is
Atsushi Mizokami +2 more
exaly +2 more sources
CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation
Frontiers in Cell and Developmental Biology, 2023 Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment.
Masakazu Toya +9 more
doaj +2 more sources
The prognostic significance of CCL2 in oral squamous cell carcinoma: insights from tissue expression and perioperative serum profiling [PDF]
Frontiers in OncologyObjectiveThis study aims to examine the expression patterns of chemokine CCL2 in oral squamous cell carcinoma tissues, adjacent tissues and tumor microenvironment, including the examine of the paraffin block and the examination of the peripheral blood ...
Senli Wen, Senli Wen, Haolei Tan
doaj +2 more sources
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis
Frontiers in Immunology, 2019 Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types both during physiological immune defense and in pathological ...
Martha Gschwandtner +2 more
exaly +2 more sources
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis
Cell Communication and SignalingBackground Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation.
Yue Dong +13 more
doaj +2 more sources
Role of CCL2/MCP-1 in Islet Transplantation
Cell Transplantation, 2010 High levels of donor-derived CCL2 have been associated with poor islet allograft outcome in patients with type 1 diabetes. The aim of our work was to determine whether CCL2 secreted by the islet has independent proinflammatory effects that influence ...
Raffaella Melzi +10 more
doaj +5 more sources
Сибирский онкологический журнал, 2021 Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement ...
S. O. Gening +7 more
doaj +1 more source
Molecular markers of cardiac fibrosis after myocardial infarction
Фундаментальная и клиническая медицина, 2022 Aim. To perform a screening for molecular markers of cardiac fibrosis upon myocardial infarction.Materials and Methods. We carried out echocardiography-guided endomyocardial biopsy of affected and intact interventricular septum segments of 7 patients ...
O. L. Barbarash +8 more
doaj +1 more source
Cancer Biology & Therapy, 2023 Background Oral tongue cancer is an extremely malignant tumor with high rate of lymphatic metastasis. Little is known about its invasion and metastasis mechanisms so far. Methods To clarify the main role of CCL2 in tongue cancer progression, we performed
Yuqing Dong +6 more
doaj +1 more source