The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration [PDF]
Journal of Neuroinflammation, 2022 Background Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response.
Aaron D. Talsma +3 more
doaj +2 more sources
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
doaj +1 more source
Clinical significance of CCL2 expression in osteosarcoma tissue [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Osteosarcoma is a primary malignant tumor in bone tissue, mainly in adolescents. The prognosis of patients with lung metastasis is poor.
巩润泽, 胡海燕
doaj +2 more sources
The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. [PDF]
PLoS ONE, 2012 Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), belongs to the CC chemokine family that is associated with the disease status and outcomes of osteoarthritis (OA).
Yu-Min Lin +4 more
doaj +1 more source
Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
Cell Death and Disease, 2022 For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines and their receptors is an ongoing antitumor strategy established on the crucial ...
Zihang Ling +10 more
doaj +1 more source
Chemokine Ligand 2 Promotes Migration in Osteosarcoma by Regulating the miR-3659/MMP-3 Axis
Biomedicines, 2023 Osteosarcoma is a common malignant tumor in children and adolescents, known for its aggressive invasion and distant metastasis, leading to a poor prognosis.
Yu-Hsiang Chang +6 more
doaj +1 more source
Phenotyping CCL2 Containing Central Amygdala Neurons Controlling Alcohol Withdrawal-Induced Anxiety
Frontiers in Cellular Neuroscience, 2020 Chemokines such as chemokine (C-C motif) ligand 2 (CCL2) play a role in several behaviors, including anxiety-like behavior, but whether neurons are an important source of CCL2 for behavior and how neuronal CCL2 may work to affect behavior are still ...
Kathryn M. Harper +12 more
doaj +1 more source
Journal of Pharmacological Sciences, 2014 .: Methamphetamine addiction is characterized by drug craving caused by stimulation of the reward system. Because neuroinflammation underlies several neurological disorders, we investigated whether CC-chemokine ligand 2 (CCL2) participates in the ...
Naoki Wakida +5 more
doaj +1 more source
Orthopaedic Surgery, 2023 Objective Wear particles induce inflammation and the further osteolysis around the prosthesis, has been proven to be the main cause of aseptic hip joint loosening. In this research, we aimed to clarify whether human umbilical cord mesenchymal stem cells (
Shixun Li +9 more
doaj +1 more source
The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation
JCI Insight, 2022 Stromal cells are emerging as key drivers of autoimmunity, partially because they produce inflammatory chemokines that orchestrate inflammation. Chemokine expression is regulated transcriptionally but also through posttranscriptional mechanisms, the ...
Rami Bechara +7 more
doaj +1 more source