Results 11 to 20 of about 59,942 (256)

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.

PLoS ONE, 2012
Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses.
Ulrich F O Luhmann, Clemens A Lange, Scott Robbie, Peter M G Munro, Jill A Cowing, Hannah E J Armer, Vy Luong, Livia S Carvalho, Robert E MacLaren, Frederick W Fitzke, James W B Bainbridge, Robin R Ali   +11 more
doaj   +6 more sources

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

Neoplasia: An International Journal for Oncology Research, 2014
The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor cells; thus, identifying the mechanisms regulating CCL2 release by these cells may enable the future design ...
Yaeli Lebel-Haziv, Tsipi Meshel, Gali Soria, Adva Yeheskel, Elad Mamon, Adit Ben-Baruch   +5 more
doaj   +3 more sources

Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. [PDF]

ACS Omega, 2020
An integrated and controlled migration of leukocytes is necessary for the legitimate functioning and maintenance of the immune system. Chemokines and their receptors play a decisive role in regulating the leukocyte migration to the site of inflammation, a phenomena often referred to as chemotaxis.
Joshi N, Kumar D, Poluri KM.
europepmc   +5 more sources

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]

Clinical and Translational Allergy, 2020
AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur, Marusa Rihar, Ana Koren, Matija Rijavec, Peter Kopac, Urska Bidovec-Stojkovic, Renato Erzen, Peter Korosec   +7 more
openaire   +3 more sources

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. [PDF]

J Neurosci, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly understood.
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, Perry VH, Bozzi Y, Caleo M.   +8 more
europepmc   +9 more sources

The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]

Toxicological Sciences, 2011
Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects.
Godefroy, D., Gosselin, R.D., Yasutake, A., Fujimura, M., Combadière, C., Maury-Brachet, R., Laclau, M., Rakwal, R., Melik-Parsadaniantz, S., Bourdineaud, J.P., Rostène, W.   +10 more
openaire   +3 more sources

CCL2 nitration is a negative regulator of chemokine-mediated inflammation [PDF]

Scientific Reports, 2017
AbstractChemokines promote leukocyte recruitment during inflammation. The oxidative burst is an important effector mechanism, this leads to the generation of reactive nitrogen species (RNS), including peroxynitrite (ONOO). The current study was performed to determine the potential for nitration to alter the chemical and biological properties of the ...
Barker, Catriona E., Thompson, Sarah, O’boyle, Graeme, Lortat-Jacob, Hugues, Sheerin, Neil S., Ali, Simi, Kirby, John A.   +6 more
openaire   +5 more sources

Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients. [PDF]

BMC Cancer, 2019
Abstract Background: Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue ...
Kishimoto T, Fujimoto N, Ebara T, Omori T, Oguri T, Niimi A, Yokoyama T, Kato M, Usami I, Nishio M, Yoshikawa K, Tokuyama T, Tamura M, Yokoyama Y, Tsuboi K, Matsuo Y, Xu J, Takahashi S, Abdelgied M, Alexander WT, Alexander DB, Tsuda H.   +21 more
europepmc   +5 more sources

CXCL10 ( ) and CCL2 ( ) chemokines in systemic sclerosis a longitudinal study [PDF]

Rheumatology, 2008
To measure serum levels of CXCL10 and CCL2 chemokines in patients with SSc, and relate the findings to clinical phenotype and disease progression.Serum CXCL10 and CCL2 were assayed in 72 consecutive newly diagnosed SSc patients and in 72 sex- and age-matched controls. In 37 SSc and 37 controls, serum CXCL10 and CCL2 were re-evaluated 5 yrs later.SSc at
ANTONELLI, ALESSANDRO, Ferri C, Fallahi P, Ferrari SM, Giuggioli D, Colaci M, Manfredi A, Frascerra S, FRANZONI, FERDINANDO, GALETTA, FABIO, FERRANNINI, ELEUTERIO   +10 more
openaire   +2 more sources

The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion [PDF]

Molecular Cancer Research, 2015
Abstract Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand–receptor interactions between nerves and cancer cells that support the process of perineural invasion.
Shizhi, He, Shuangba, He, Chun-Hao, Chen, Sylvie, Deborde, Richard L, Bakst, Natalya, Chernichenko, William F, McNamara, Sei Young, Lee, Fernando, Barajas, Zhenkun, Yu, Hikmat A, Al-Ahmadie, Richard J, Wong   +11 more
openaire   +2 more sources