Results 11 to 20 of about 63,435 (292)

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. [PDF]

PLoS ONE, 2012
Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses.
Ulrich F O Luhmann, Clemens A Lange, Scott Robbie, Peter M G Munro, Jill A Cowing, Hannah E J Armer, Vy Luong, Livia S Carvalho, Robert E MacLaren, Frederick W Fitzke, James W B Bainbridge, Robin R Ali   +11 more
doaj   +7 more sources

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

Neoplasia: An International Journal for Oncology Research, 2014
The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor cells; thus, identifying the mechanisms regulating CCL2 release by these cells may enable the future design ...
Yaeli Lebel-Haziv, Tsipi Meshel, Gali Soria, Adva Yeheskel, Elad Mamon, Adit Ben-Baruch   +5 more
doaj   +4 more sources

CCL2 nitration is a negative regulator of chemokine-mediated inflammation [PDF]

Scientific Reports, 2017
International audienceChemokines promote leukocyte recruitment during inflammation. The oxidative burst is an important effector mechanism, this leads to the generation of reactive nitrogen species (RNS), including peroxynitrite (ONOO). The current study
Kirby, John A., Ali, Simi, John A. Kirby, Lortat-Jacob, Hugues, Kirby, John A, Thompson, Sarah, O'Boyle, Graeme, Sheerin, Neil S., Graeme O’Boyle, Barker, Catriona E., Catriona E. Barker, Sarah Thompson, Simi Ali, O’boyle, Graeme, Sheerin, Neil S, Hugues Lortat-Jacob, Neil S. Sheerin, Barker, Catriona E   +17 more
core   +8 more sources

Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes [PDF]

The Journal of Immunology, 2014
Chemokine-directed leukocyte migration is crucial for effective immune and inflammatory responses. Conventional chemokine receptors (cCKRs) directly control cell movement; atypical chemokine receptors (ACKRs) regulate coexpressed cCKRs; and both cCKRs ...
Hansell, Chris A.H., Nibbs, Robert J.B., Graham, Gerard J., Cerovic, Vuk, Milling, Simon W.F., Ford, Laura B.   +5 more
core   +3 more sources

Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor

Virology, 2010
Human herpesvirus 8 (HHV-8) is associated with Kaposi's sarcoma (KS), an endothelial cell lesion believed to be initiated and driven primarily by cytokine dysregulation.
Nicholas, John, Young Bong Choi, John Nicholas, Choi, Young Bong   +3 more
core   +3 more sources

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. [PDF]

J Neurosci, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, Perry VH, Bozzi Y, Caleo M.   +8 more
europepmc   +10 more sources

CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD.

PLoS ONE, 2014
The chemokine receptors CX3CR1 and CCR2 have been implicated in the development of age-related macular degeneration (AMD). The evidence is mainly derived from experimental cell studies and murine models of AMD.
Singh, Amardeep, Sørensen, Torben Lykke, Faber, Carsten, Torben Lykke Sørensen, Nissen, Mogens Holst, Mogens Holst Nissen, Carsten Faber, Mads Krüger Falk, Amardeep Singh, Falk, Mads Krüger, Hviid, Thomas, Thomas Hviid   +11 more
core   +6 more sources

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn. [PDF]

J Neuroinflammation, 2021
Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR) function at ...
Heles M, Mrozkova P, Sulcova D, Adamek P, Spicarova D, Palecek J.   +5 more
europepmc   +2 more sources

Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. [PDF]

ACS Omega, 2020
An integrated and controlled migration of leukocytes is necessary for the legitimate functioning and maintenance of the immune system. Chemokines and their receptors play a decisive role in regulating the leukocyte migration to the site of inflammation, a phenomena often referred to as chemotaxis.
Joshi N, Kumar D, Poluri KM.
europepmc   +5 more sources

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]

Clinical and Translational Allergy, 2020
AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur, Marusa Rihar, Ana Koren, Matija Rijavec, Peter Kopac, Urska Bidovec-Stojkovic, Renato Erzen, Peter Korosec   +7 more
openaire   +3 more sources