CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]
, 2011 Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells.
Pollard, Jeffrey W +17 more
core +1 more source
CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation
Frontiers in Cell and Developmental Biology, 2023 Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment.
Masakazu Toya +9 more
doaj +1 more source
Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases [PDF]
Biomedical Papers, 2006 Chemokines and chemokine receptors are major mediators of leukocyte trafficking into the sites of the immune response. They participate in defence against microbial infection, in Th1/Th2 polarization of the immune response, allograft rejection and angiogenesis/angiostasis as well as in tumorigenesis and metastasis.
openaire +2 more sources
Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study
Scientific Reports, 2017 Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C
Katsuhiro Oda +8 more
doaj +1 more source
Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
PLoS Biology, 2019 Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee +7 more
doaj +1 more source
P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]
, 2014 This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H. +11 more
core +1 more source
CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir
mBio, 2022 There are currently over 35 million people living with HIV worldwide, and we still have no vaccine or scalable cure. One of the difficulties with HIV is its ability to rapidly establish a viral reservoir in lymphoid tissues that allows it to elude antivirals and the immune system.
Thomas A. Packard +16 more
openaire +4 more sources
Frontiers in Veterinary Science, 2023 Porcine embryos are used for a variety of applications. However, the maturation rate in vitro remains low, and novel in vitro maturation (IVM) techniques that facilitate the collection of mature oocytes are necessary.
Sohee Kim +20 more
doaj +1 more source
, 2017 Background/Purpose: Henoch-Schonlein purpura (HSP) is the most common small vessel vasculitis in children. It is considered to be an IgA-containing immune complex-mediated disease.
王麗潔;李志鴻;俞欣慧;江伯倫;楊曜旭;陳為堅 +1 more
core +2 more sources
CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice.
PLoS ONE, 2016 Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear.
Xuguang Chen +8 more
doaj +1 more source