Results 31 to 40 of about 59,942 (256)

CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

mBio, 2022
There are currently over 35 million people living with HIV worldwide, and we still have no vaccine or scalable cure. One of the difficulties with HIV is its ability to rapidly establish a viral reservoir in lymphoid tissues that allows it to elude antivirals and the immune system.
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene   +16 more
openaire   +4 more sources

CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice.

PLoS ONE, 2016
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear.
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins   +8 more
doaj   +1 more source

Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Frontiers in Immunology, 2020
Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo.
Daniela Angela Covino, Karolina Elżbieta Kaczor-Urbanowicz, Karolina Elżbieta Kaczor-Urbanowicz, Jing Lu, Maria Vincenza Chiantore, Gianna Fiorucci, Gianna Fiorucci, Maria Fenicia Vescio, Laura Catapano, Cristina Purificato, Clementina Maria Galluzzo, Roberta Amici, Mauro Andreotti, Maria Cristina Gauzzi, Matteo Pellegrini, Laura Fantuzzi   +15 more
doaj   +1 more source

In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2

Journal of Translational Medicine, 2011
Background Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors.
Meropol Neal J, Mastrangelo Michael, Gross Laura, Zhang Tianqian, Rani Pyapalli, Berencsi Klara, Herlyn Dorothee, Somasundaram Rajasekharan   +7 more
doaj   +1 more source

Chemokines in ICU Delirium: An Exploratory Study

Critical Care Explorations, 2022
OBJECTIVES:. The pathophysiology of delirium is complex and incompletely understood. Inflammation is hypothesized to be integral to its development due to effects on blood brain barrier integrity, facilitation of leukocyte extravasation into brain ...
Ryan J. Smith, MD, JD, Alejandro A. Rabinstein, MD, Rodrigo Cartin-Ceba, MD, MSc, Vijay P. Singh, MBBS, MD, Christian Lachner, MD, Biswajit Khatua, PhD, Shubham Trivedi, BS, Ognjen Gajic, MD   +7 more
doaj   +1 more source

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis [PDF]

Fibrogenesis & Tissue Repair, 2011
AbstractBackgroundPulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors.
Palchevskiy, Vyacheslav, Hashemi, Nastran, Weigt, Stephen S, Xue, Ying Ying, Derhovanessian, Ariss, Keane, Michael P, Strieter, Robert M, Fishbein, Michael C, Deng, Jane C, Lynch, Joseph P, Elashoff, Robert, Belperio, John A   +11 more
openaire   +5 more sources

The Role of Serum CC-Chemokine Ligand 2 (CCL2) in Obesity: A Comparative Study with Normal Subjects [PDF]

BIO Web of Conferences
Excess fat in the visceral area in the form of obesity is associated with metabolic syndrome. Various factors have been identified that contribute to the pathophysiology of obesity-related metabolic diseases, including chronic inflammatory factors and ...
Lestarini Asri, Aryastuti Anak Agung Sri Agung, Witari Ni Putu Diah, Dewi Ni Wayan Erly Sintya   +3 more
doaj   +1 more source

Genetic variants of chemokine CCL2 and chemokine receptor CCR2 genes and risk of prostate cancer

Tumor Biology, 2014
Chemokines and their receptors acts as mediators of migration of immune cells to the site of inflammation and deregulated inflammatory response is associated with increased risk of cancer. We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for ...
Raju K, Mandal, Toshi, Agrawal, Rama Devi, Mittal   +2 more
openaire   +2 more sources

Coordinated Post-Transcriptional Regulation of the Chemokine System: Messages from CCL2 [PDF]

Journal of Interferon & Cytokine Research, 2014
The molecular cross-talk between epithelium and immune cells in the airway mucosa is a key regulator of homeostatic immune surveillance and is crucially involved in the development of chronic lung inflammatory diseases. The patterns of gene expression that follow the sensitization process occurring in allergic asthma and chronic rhinosinusitis and ...
Ronaldo P. Panganiban, Becky M. Vonakis, Faoud T. Ishmael, STELLATO, Cristiana   +3 more
openaire   +3 more sources

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer

Frontiers in Pharmacology
Solid tumors present a significant challenge to Chimeric Antigen Receptor (CAR) -T cell therapy, primarily due to limited T-cell infiltration and persistence in the tumor microenvironment.
Raj Kumar, Irva E. Veillard, Mengyao Xu, Linah Al-Alem, Bo R. Rueda, Bo R. Rueda, Oladapo O. Yeku   +6 more
doaj   +1 more source