Results 51 to 60 of about 63,435 (292)

CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study

Cancer Research and Treatment, 2014
Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa.Preoperative and early ...
Tsaur, Igor, Noack, Anika, Makarević, Jasmina, Oppermann, Elsie, Waaga, Ana Maria da Silva Rosa, Gasser, Martin, Borgmann, Hendrik, Huesch, Tanja, Gust, Kilian, Reiter, Michael Andreas, Schilling, David, Bartsch, Georg, Haferkamp, Axel, Blaheta, Roman A.   +13 more
openaire   +3 more sources

Coordinated Post-Transcriptional Regulation of the Chemokine System: Messages from CCL2 [PDF]

Journal of Interferon & Cytokine Research, 2014
The molecular cross-talk between epithelium and immune cells in the airway mucosa is a key regulator of homeostatic immune surveillance and is crucially involved in the development of chronic lung inflammatory diseases. The patterns of gene expression that follow the sensitization process occurring in allergic asthma and chronic rhinosinusitis and ...
Ronaldo P. Panganiban, Becky M. Vonakis, Faoud T. Ishmael, STELLATO, Cristiana   +3 more
openaire   +3 more sources

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer

Frontiers in Pharmacology
Solid tumors present a significant challenge to Chimeric Antigen Receptor (CAR) -T cell therapy, primarily due to limited T-cell infiltration and persistence in the tumor microenvironment.
Raj Kumar, Irva E. Veillard, Mengyao Xu, Linah Al-Alem, Bo R. Rueda, Bo R. Rueda, Oladapo O. Yeku   +6 more
doaj   +1 more source

Loss of Transforming Growth Factor-β Signaling in Mammary Fibroblasts Enhances CCL2 Secretion to Promote Mammary Tumor Progression through Macrophage-Dependent and -Independent Mechanisms

Neoplasia: An International Journal for Oncology Research, 2010
Whereas the accumulation of fibroblasts and macrophages in breast cancer is a well-documented phenomenon and correlates with metastatic disease, the functional contributions of these stromal cells on breast cancer progression still remain largely unclear.
Stacey L. Hembruff, Iman Jokar, Li Yang, Nikki Cheng   +3 more
doaj   +1 more source

Importance of chemokine (CC-motif) ligand 2 in breast cancer

The International Journal of Biological Markers, 2012
Breast cancer is the leading cause of cancer-related death in women in the United States. Chemokine (CC-motif) ligand 2 (CCL2), an inflammatory cytokine and chemokine, is highly expressed within the tumor and stromal cell populations and has been ...
Jennifer L. Steiner, E. Angela Murphy PhD   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The effects of 4-week aerobic exercise on the levels of CCL2, CCL5, and their respective receptors in female BALB/C mice suffering from breast cancer

Advanced Biomedical Research, 2023
Background: The studies reported that chemokines Chemokine (C-C motif) ligand 2 (CCL2) and Chemokine (C-C motif) ligand 5 (CCL5) have tumor-promoting roles in breast cancer (BC).
Mehrnoosh Esmailiyan, Mehdi Kargarfard, Fahimeh Esfarjani, Golnaz Vaseghi, Shaghayegh Haghjooy Javanmard, Atefeh Amerizadeh   +5 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Proinflammatory chemokine gene expression influences survival of patients with non-Hodgkin’s lymphoma

Folia Histochemica et Cytobiologica, 2011
The migration, survival and proliferation of cells is the basis for all physiologic and pathologic processes in the human body. All these reactions are regulated by a complex chemokine network that guides lymphocytes homing, chemotaxis, adhesion and ...
Kazimierz Kuliczkowski, Andrzej Lange, Tomasz Wróbel, Aleksandra Butrym, Dorota Dłubek, Ilona Kryczek, Emilia Jaskuła, Grzegorz Mazur   +7 more
doaj   +1 more source

The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

, 2023
The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and ...
C Roomruangwong (13330680), A F Carvalho (13330368), Michael Maes (13055841), S Sirivichayakul (13330596)   +3 more
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