Results 61 to 70 of about 63,435 (292)
Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2
, 2023 International audienceBidirectional dialogue between cellular and non-cellular components of the tumor microenvironment (TME) drives cancer survival. In the extracellular space, combinations of matrix molecules and soluble mediators provide external cues
Thomas Loustau +29 more
core +1 more source
Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2 [PDF]
The Journal of Experimental Medicine, 2004 CD1d-restricted Vα24-Jα18–invariant natural killer T cells (iNKTs) are potentially important in tumor immunity. However, little is known about their localization to tumors. We analyzed 98 untreated primary neuroblastomas from patients with metastatic disease (stage 4) for tumor-infiltrating iNKTs using TaqMan® reverse transcription polymerase chain ...
Metelitsa, Leonid S. +8 more
openaire +2 more sources
The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir [PDF]
, 2021 ABSTRACT HIV infects long-lived CD4 memory T cells establishing a latent viral reservoir that necessitates lifelong anti-retroviral therapy (ART). How this reservoir is formed so swiftly remains unknown. We now show the innate inflammatory response to HIV infection results in CCL2 chemokine release, which can drive recruitment of cells ...
Thomas A. Packard +16 more
openaire +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Expression Changes of Serum IL-1α, CCL2, and CXCL2 in Patients With Pemphigus
International Journal of Dermatology and Venerology, 2023 Objective:. This study was performed to explore the possible changes of the serum levels of the cytokines including interleukin 1α (IL-1 α), chemokine monocyte chemotactic protein 1 (also known as chemokine [C-C motif] ligand 2 [CCL2]), and C-X-C motif ...
Li-Dan Mao +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells
eLife, 2018 Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells.
Eva Plesch +18 more
doaj +1 more source
Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain [PDF]
Frontiers in Cellular Neuroscience, 2014 The development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. Thus the injured nerve initiates a response of microglia, which represents the start of a cascade of events that leads to neuropathic pain development.
Knut eBiber, Knut eBiber, Erik eBoddeke
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy
Zhongliu Fangzhi Yanjiu, 2019 Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes.
LU Xiaomei, FU Jiejun
doaj +1 more source