Results 21 to 30 of about 59,942 (256)

Characterization of Conventional and Atypical Receptors for the Chemokine CCL2 on Mouse Leukocytes [PDF]

The Journal of Immunology, 2014
Abstract Chemokine-directed leukocyte migration is crucial for effective immune and inflammatory responses. Conventional chemokine receptors (cCKRs) directly control cell movement; atypical chemokine receptors (ACKRs) regulate coexpressed cCKRs; and both cCKRs and ACKRs internalize chemokines to limit their abundance in vivo, a process ...
Laura B, Ford, Vuk, Cerovic, Simon W F, Milling, Gerard J, Graham, Chris A H, Hansell, Robert J B, Nibbs   +5 more
openaire   +2 more sources

The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation

JCI Insight, 2022
Stromal cells are emerging as key drivers of autoimmunity, partially because they produce inflammatory chemokines that orchestrate inflammation. Chemokine expression is regulated transcriptionally but also through posttranscriptional mechanisms, the ...
Rami Bechara, Nilesh Amatya, Saikat Majumder, Chunsheng Zhou, Yang Li, Qixing Liu, Mandy J. McGeachy, Sarah L. Gaffen   +7 more
doaj   +1 more source

Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor

Virology, 2010
Human herpesvirus 8 (HHV-8) is associated with Kaposi's sarcoma (KS), an endothelial cell lesion believed to be initiated and driven primarily by cytokine dysregulation. Among the viral proteins suspected as contributing to viral pathogenesis is the lytically expressed viral G protein-coupled receptor (vGPCR), which can induce various cellular ...
Choi, Young Bong, Nicholas, John
openaire   +2 more sources

Predictive value of CCL2 in the prognosis and immunotherapy response of glioblastoma multiforme

BMC Genomics, 2023
Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor with a poor prognosis. The C-C motif chemokine ligand 2 (CCL2) has shown abnormal expression associated with progression of multiple malignancies, however, its ...
Longfei Deng, Jie Ren, Benqin Li, Yinggang Wang, Nianfen Jiang, Yi Wang, Hongjuan Cui   +6 more
doaj   +1 more source

Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study

Scientific Reports, 2017
Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C
Katsuhiro Oda, Takuya Kotani, Tohru Takeuchi, Takaaki Ishida, Takeshi Shoda, Kentaro Isoda, Shuzo Yoshida, Yasuichiro Nishimura, Shigeki Makino   +8 more
doaj   +1 more source

The effect of C–C motif chemokine ligand 2 supplementation on in vitro maturation of porcine cumulus-oocyte complexes and subsequent developmental competence after parthenogenetic activation

Frontiers in Veterinary Science, 2023
Porcine embryos are used for a variety of applications. However, the maturation rate in vitro remains low, and novel in vitro maturation (IVM) techniques that facilitate the collection of mature oocytes are necessary.
Sohee Kim, Sohee Kim, Dongjin Oh, Dongjin Oh, Hyerin Choi, Hyerin Choi, Mirae Kim, Mirae Kim, Lian Cai, Lian Cai, Lian Cai, Ali Jawad, Ali Jawad, Zheng Haomiao, Zheng Haomiao, Joohyeong Lee, Joohyeong Lee, Eunhye Kim, Sang-Hwan Hyun, Sang-Hwan Hyun, Sang-Hwan Hyun   +20 more
doaj   +1 more source

Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases [PDF]

Biomedical Papers, 2006
Chemokines and chemokine receptors are major mediators of leukocyte trafficking into the sites of the immune response. They participate in defence against microbial infection, in Th1/Th2 polarization of the immune response, allograft rejection and angiogenesis/angiostasis as well as in tumorigenesis and metastasis.
openaire   +2 more sources

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.

PLoS Biology, 2019
Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging receptor. ACKR2-/-embryos display a reduction in size of a novel, to our knowledge, embryonic skin macrophage population referred to as 'intermediate' cells. CC chemokine receptor 2 (CCR2)-/-
Kit Ming Lee, Gillian J Wilson, Marieke Pingen, Ayumi Fukuoka, Christopher A H Hansell, Robin Bartolini, Laura Medina-Ruiz, Gerard J Graham   +7 more
doaj   +1 more source

CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation

Frontiers in Cell and Developmental Biology, 2023
Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment.
Masakazu Toya, Ning Zhang, Ning Zhang, Masanori Tsubosaka, Junichi Kushioka, Qi Gao, Xueping Li, Simon Kwoon-Ho Chow, Stuart B. Goodman, Stuart B. Goodman   +9 more
doaj   +1 more source

CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD

PLoS ONE, 2014
The chemokine receptors CX3CR1 and CCR2 have been implicated in the development of age-related macular degeneration (AMD). The evidence is mainly derived from experimental cell studies and murine models of AMD. The purpose of this study was to investigate the association between expression of CX3CR1 and CCR2 on different leukocyte subsets and AMD ...
Falk, Mads Krüger, Singh, Amardeep, Faber, Carsten, Nissen, Mogens Holst, Hviid, Thomas, Sørensen, Torben Lykke   +5 more
openaire   +5 more sources