Results 21 to 30 of about 63,435 (292)

The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]

Toxicological Sciences, 2011
Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects.
Godefroy, D., Gosselin, R.D., Yasutake, A., Fujimura, M., Combadière, C., Maury-Brachet, R., Laclau, M., Rakwal, R., Melik-Parsadaniantz, S., Bourdineaud, J.P., Rostène, W.   +10 more
openaire   +3 more sources

Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients. [PDF]

BMC Cancer, 2019
Abstract Background: Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue ...
Kishimoto T, Fujimoto N, Ebara T, Omori T, Oguri T, Niimi A, Yokoyama T, Kato M, Usami I, Nishio M, Yoshikawa K, Tokuyama T, Tamura M, Yokoyama Y, Tsuboi K, Matsuo Y, Xu J, Takahashi S, Abdelgied M, Alexander WT, Alexander DB, Tsuda H.   +21 more
europepmc   +5 more sources

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Sayyed, Sufyan Ali, Anders, Hans-Joachim, Vielhauer, Volker   +2 more
core   +1 more source

CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. [PDF]

, 2009
BACKGROUND Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M.
Hussain Rabia, Cliff, Jacqueline M., Hasan, Z, Jamil, Bushra, Bushra Jamil, Hussain, Rabia, Cliff, Jacqueline M, Ashraf Mussarat, Hazel M Dockrell, Hasan Zahra, Jamil, B, Mussarat Ashraf, Jacqueline M Cliff, Ashraf, Mussarat, Cliff Jacqueline M., Cliff, JM, Irfan, Muhammad, Irfan Muhammad, Ashraf, M, Hussain, R, Muhammad Irfan, Hasan, Zahra, Dockrell Hazel M., Dockrell, HM, Irfan, M, Jamil Bushra, Dockrell, Hazel M, Rabia Hussain, Zahra Hasan   +28 more
core   +1 more source

CXCL10 ( ) and CCL2 ( ) chemokines in systemic sclerosis a longitudinal study [PDF]

Rheumatology, 2008
To measure serum levels of CXCL10 and CCL2 chemokines in patients with SSc, and relate the findings to clinical phenotype and disease progression.Serum CXCL10 and CCL2 were assayed in 72 consecutive newly diagnosed SSc patients and in 72 sex- and age-matched controls. In 37 SSc and 37 controls, serum CXCL10 and CCL2 were re-evaluated 5 yrs later.SSc at
A. ANTONELLI, FERRI, Clodoveo, P. FALLAHI, FERRARI, Silvia Martina, D. GIUGGIOLI, COLACI, Michele, MANFREDI, Andreina Teresa, S. FRASCERRA, F. FRANZONI, F. GALETTA, E. FERRANNINI   +10 more
openaire   +2 more sources

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]

, 2014
Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D, Suzuki, H., Forrest, Alistair R. R., Hasegawa, Y., Suzuki, H, Ovchinnikov, Dmitry A., Hitchens, Kelly J., Takahashi, N., Forrest, A.R.R., Kenna, Tony, Suzuki, Harukazu, Tang, D., Joshi, Anagha, Hayashizaki, Y., Wolvetang, Ernst, Tang, Dave, Suzuki, H., Forrest, Alistair R R, FANTOM Consortium, the FANTOM consortium, Vijayan, Dipti, Wells, Christine A., Hasegawa, Y, Hayashizaki, Yoshihide, Forrest, ARR, Takahashi, Naoko, Briggs, James, Hasegawa, Yuki, Blumenthal, Antje, Tang, D., Hayashizaki, Y, ?, ?, Sajantila, Antti, Hasegawa, Y., Takahashi, N, Takahashi, N., Forrest, A. R., Beckhouse, Anthony G., FANTOM Consortium,, Hayashizaki, Y.   +39 more
core   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga, Nina Berberich, Peter Bihari, Stefan Zahler, Rehberg, Markus, Fritz Krombach, Krombach, Fritz, Max Lerchenberger, Lerchenberger, Max, Berberich, Nina, Reichel, Christoph A., Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Zahler, Stefan, Khandoga, Alexander G.   +15 more
core   +1 more source

The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion [PDF]

Molecular Cancer Research, 2015
Abstract Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand–receptor interactions between nerves and cancer cells that support the process of perineural invasion.
Shizhi, He, Shuangba, He, Chun-Hao, Chen, Sylvie, Deborde, Richard L, Bakst, Natalya, Chernichenko, William F, McNamara, Sei Young, Lee, Fernando, Barajas, Zhenkun, Yu, Hikmat A, Al-Ahmadie, Richard J, Wong   +11 more
openaire   +2 more sources

Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]

, 2005
Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders, Ninichuk, Volha, Anders, Hans-Joachim, Volha Ninichuk   +3 more
core   +1 more source

Predictive value of CCL2 in the prognosis and immunotherapy response of glioblastoma multiforme

BMC Genomics, 2023
Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor with a poor prognosis. The C-C motif chemokine ligand 2 (CCL2) has shown abnormal expression associated with progression of multiple malignancies, however, its ...
Longfei Deng, Jie Ren, Benqin Li, Yinggang Wang, Nianfen Jiang, Yi Wang, Hongjuan Cui   +6 more
doaj   +1 more source