Results 41 to 50 of about 107,958 (309)

The molecular structure and role of CCL2 (MCP‐1) and C‐C chemokine receptor CCR2 in skeletal biology and diseases

Journal of Cellular Physiology, 2021
Monocyte chemoattractant protein‐1, also called chemokine (C‐C motif) ligand 2 (CCL2) or small inducible cytokine A2, is an inflammatory mediator capable of recruiting monocytes, memory T cells, and dendritic cells.
Sipin Zhu, Mei Liu, Samuel Bennett, Ziyi Wang, K. Pfleger, Jiake Xu   +5 more
semanticscholar   +1 more source

Plasma Chemokine C-C Motif Ligand 2 as a Potential Biomarker for Prostate Cancer

Research and Reports in Urology, 2022
Martin Lund,1 Torben B Pedersen,1 Søren Feddersen,2,3 Louise D Østergaard,1,3 Charlotte A Poulsen,1 Christian Enggaard,2 Mads HA Poulsen,1,3 Lars Lund1,3 1Department of Urology, Odense University Hospital, Odense, Denmark; 2Department of Clinical ...
Lund M, Pedersen TB, Feddersen S, Østergaard LD, Poulsen CA, Enggaard C, Poulsen MHA, Lund L   +7 more
doaj  

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways

Osteoarthritis and Cartilage Open, 2021
Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson, Huseyin Ozkan, Susan Chubinskaya, Richard F. Loeser, Lara Longobardi   +4 more
doaj   +1 more source

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

International Immunopharmacology, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of people worldwide with different waves, resulting in the death of many ...
M. Ranjbar, A. Rahimi, Zeinab Baghernejadan, Atousa Ghorbani, H. Khorramdelazad   +4 more
semanticscholar   +1 more source

The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration

Journal of Neuroinflammation, 2022
Background Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response.
Aaron D. Talsma, Jon P. Niemi, Joel S. Pachter, Richard E. Zigmond   +3 more
doaj   +1 more source

Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis

Frontiers in Immunology, 2021
ObjectivesTo investigate vascular macrophage phenotype as well as vascular and peripheral chemokine (C-C motif) ligand 2 (CCL2) expression during different stages of disease progression in patients with Takayasu Arteritis (TA).MethodsIn this study, 74 ...
Xiufang Kong, Ming Xu, Ming Xu, Xiaomeng Cui, Lingying Ma, Huiyong Cheng, Jun Hou, Xiaoning Sun, Lili Ma, Lindi Jiang, Lindi Jiang   +10 more
doaj   +1 more source

CCL2 overexpression is associated with paclitaxel resistance in ovarian cancer cells via autocrine signaling and macrophage recruitment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
Tumor cells can secret various cytokines and chemokines, which affect the tumor cells themselves and the neighboring cells. Here, we observed that human ovarian cancer (OC) cells developed resistance to paclitaxel treatment following culture with the ...
Yeong-In Yang, Yi-Yue Wang, Ji-Hye Ahn, Bo-Hyung Kim, Jung-Hye Choi   +4 more
semanticscholar   +1 more source

CCL2 Blockade Augments Cancer Immunotherapy [PDF]

Cancer Research, 2010
Abstract Altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have both direct and indirect immunoinhibitory effects.
Zvi G, Fridlender, George, Buchlis, Veena, Kapoor, Guanjun, Cheng, Jing, Sun, Sunil, Singhal, M Cecilia, Crisanti, Cecilia, Crisanti, Liang-Chuan S, Wang, Daniel, Heitjan, Linda A, Snyder, Steven M, Albelda   +11 more
openaire   +2 more sources

The Role of Serum CC-Chemokine Ligand 2 (CCL2) in Obesity: A Comparative Study with Normal Subjects [PDF]

BIO Web of Conferences
Excess fat in the visceral area in the form of obesity is associated with metabolic syndrome. Various factors have been identified that contribute to the pathophysiology of obesity-related metabolic diseases, including chronic inflammatory factors and ...
Lestarini Asri, Aryastuti Anak Agung Sri Agung, Witari Ni Putu Diah, Dewi Ni Wayan Erly Sintya   +3 more
doaj   +1 more source

Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages.

Cancer Letters, 2021
Colorectal cancer (CRC) accounts for about 10% of cancer deaths worldwide. Colon carcinogenesis is critically influenced by the tumor microenvironment.
M. Stadler, K. Pudelko, Alexander Biermeier, N. Walterskirchen, A. Gaigneaux, C. Weindorfer, N. Harrer, Hagen Klett, M. Hengstschläger, J. Schüler, W. Sommergruber, R. Oehler, M. Bergmann, E. Letellier, H. Dolznig   +14 more
semanticscholar   +1 more source