Results 21 to 30 of about 107,958 (309)
CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]
Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015 The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy +2 more
openaire +4 more sources
CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety
Cell Discovery, 2023 High myopia is a leading cause of blindness worldwide. It may lead to emotional defects that rely closely on the link between visual sensation and the central nervous system. However, the extent of the defects and its underlying mechanism remain unknown.
Xiangjia Zhu +10 more
semanticscholar +1 more source
Targeting the CCL2–CCR2 axis for atheroprotection
European Heart Journal, 2022 AbstractDecades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for lowering residual vascular risk.
Marios K Georgakis +4 more
openaire +5 more sources
Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways
Journal of Immunotoxicology, 2020 Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C–C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain ...
Thitima Kasemsuk +4 more
doaj +1 more source
The Vascular Circadian Clock in Chronic Kidney Disease
Cells, 2021 Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular ...
Søren Egstrand +3 more
doaj +1 more source
Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?
Frontiers in Immunology, 2021 CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory functions, prompting the development of CCR2 antagonists to dampen unwanted immune responses in inflammatory and autoimmune diseases.
Liyan Fei, X. Ren, Haijia Yu, Y. Zhan
semanticscholar +1 more source
Clinical significance of CCL2 expression in osteosarcoma tissue [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Osteosarcoma is a primary malignant tumor in bone tissue, mainly in adolescents. The prognosis of patients with lung metastasis is poor.
GONG Runze, HU Haiyan
doaj +3 more sources
CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Nature, 2011 Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells.
Binzhi Qian +8 more
semanticscholar +1 more source
Cell Proliferation, 2023 In non‐small cell lung cancer (NSCLC), metastasis is the most common phenotype, and autophagy plays a vital role in its regulation. However, there are limited data on how autophagy‐related genes and metastasis‐related genes affect NSCLC progression.
Hui Xu +4 more
semanticscholar +1 more source
Peripheral CCL2-CCR2 signalling contributes to chronic headache-related sensitization.
Brain : a journal of neurology, 2023 Migraine, especially chronic migraine, is highly debilitating and still lacks effective treatment. The persistent headache arises from activation and sensitization of primary afferent neurons in the trigeminovascular pathway, but the underlying ...
S. Ryu +5 more
semanticscholar +1 more source