Results 21 to 30 of about 106,788 (300)

CCL2/CCR2 signaling in cancer pathogenesis [PDF]

Cell Communication and Signaling, 2020
AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao, Jaydutt V. Vadgama, Piwen Wang   +2 more
openaire   +3 more sources

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]

, 2014
Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D, Suzuki, H., Forrest, Alistair R. R., Hasegawa, Y., Suzuki, H, Ovchinnikov, Dmitry A., Hitchens, Kelly J., Takahashi, N., Forrest, A.R.R., Kenna, Tony, Suzuki, Harukazu, Tang, D., Joshi, Anagha, Hayashizaki, Y., Wolvetang, Ernst, Tang, Dave, Suzuki, H., Forrest, Alistair R R, FANTOM Consortium, the FANTOM consortium, Vijayan, Dipti, Wells, Christine A., Hasegawa, Y, Hayashizaki, Yoshihide, Forrest, ARR, Takahashi, Naoko, Briggs, James, Hasegawa, Yuki, Blumenthal, Antje, Tang, D., Hayashizaki, Y, ?, ?, Sajantila, Antti, Hasegawa, Y., Takahashi, N, Takahashi, N., Forrest, A. R., Beckhouse, Anthony G., FANTOM Consortium,, Hayashizaki, Y.   +39 more
core   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga, Nina Berberich, Peter Bihari, Stefan Zahler, Rehberg, Markus, Fritz Krombach, Krombach, Fritz, Max Lerchenberger, Lerchenberger, Max, Berberich, Nina, Reichel, Christoph A., Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Zahler, Stefan, Khandoga, Alexander G.   +15 more
core   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells.
Pollard, Jeffrey W, Zhang, Hui, Jeffrey W. Pollard, Jiufeng Li, Bin-Zhi Qian, Jinghang Zhang, Campion, Liam R, Kaiser, Elizabeth A, Liam R. Campion, Zhang, Jinghang, Snyder, Linda A, Kitamura, Takanori, Qian, Binzhi, Li, Jiufeng, Elizabeth A. Kaiser, Takanori Kitamura, Linda A. Snyder, Hui Zhang   +17 more
core   +1 more source

CCL2 at the crossroad of cancer metastasis [PDF]

JAK-STAT, 2013
Primary tumors can affect organ functions, either mechanically when they grow to a considerable size or via production of hormones. However, mortality of cancer patients is in most cases due to formation of secondary growths.(1) (,) (2) Consequently, various drugs are currently employed in clinical trials to impair specific steps of cancer metastasis ...
openaire   +2 more sources

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

OncoImmunology, 2017
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and ...
Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, Niels J.M. Verstegen, Kim Vrijland, Metamia Ciampricotti, Chris W. Doornebal, Cheei-Sing Hau, Max D. Wellenstein, Camilla Salvagno, Parul Doshi, Esther H. Lips, Lodewyk F.A. Wessels, Karin E. de Visser   +13 more
doaj   +1 more source

Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy

Zhongliu Fangzhi Yanjiu, 2019
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes.
LU Xiaomei, FU Jiejun
doaj   +1 more source

CCL2 Blockade Augments Cancer Immunotherapy [PDF]

Cancer Research, 2010
Abstract Altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have both direct and indirect immunoinhibitory effects.
Zvi G, Fridlender, George, Buchlis, Veena, Kapoor, Guanjun, Cheng, Jing, Sun, Sunil, Singhal, M Cecilia, Crisanti, Cecilia, Crisanti, Liang-Chuan S, Wang, Daniel, Heitjan, Linda A, Snyder, Steven M, Albelda   +11 more
openaire   +2 more sources

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways

Osteoarthritis and Cartilage Open, 2021
Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson, Huseyin Ozkan, Susan Chubinskaya, Richard F. Loeser, Lara Longobardi   +4 more
doaj   +1 more source

The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration

Journal of Neuroinflammation, 2022
Background Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response.
Aaron D. Talsma, Jon P. Niemi, Joel S. Pachter, Richard E. Zigmond   +3 more
doaj   +1 more source