Results 11 to 20 of about 100,029 (302)

CCL2, CCR2 Gene Variants and CCL2, CCR2 Serum Levels Association with Age-Related Macular Degeneration

Life, 2022
Background: Age-related macular degeneration (AMD) is the most common cause of progressive and irreversible blindness in developed countries. Although the pathogenesis is not fully understood, AMD is a multifactorial pathology with an accumulation of inflammatory components and macrophages and a strong genetic predisposition.
Gaile Gudauskiene, Alvita Vilkeviciute, Greta Gedvilaite, Rasa Liutkeviciene, Dalia Zaliuniene   +4 more
openaire   +4 more sources

IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation

Journal of Inflammation Research, 2022
Nadeem Akhter,1 Shihab Kochumon,1 Amal Hasan,1 Ajit Wilson,1 Rasheeba Nizam,2 Ashraf Al Madhoun,2,3 Fatema Al-Rashed,1 Hossein Arefanian,1 Fawaz Alzaid,2,4 Sardar Sindhu,1,3 Fahd Al-Mulla,1 Rasheed Ahmad1 1Immunology & Microbiology Department, Dasman ...
Akhter N, Kochumon S, Hasan A, Wilson A, Nizam R, Al Madhoun A, Al-Rashed F, Arefanian H, Alzaid F, Sindhu S, Al-Mulla F, Ahmad R   +11 more
doaj   +1 more source

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration

Experimental Eye Research, 2013
Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been implicated in the pathogenesis of age-related macular degeneration. Defects in Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling cause enhanced accumulation of bloated subretinal microglia/macrophages in
Luhmann, Ulrich F.O., Carvalho, Livia S., Robbie, Scott J., Cowing, Jill A., Duran, Yanai, Munro, Peter M.G., Bainbridge, James W.B., Ali, Robin R.   +7 more
openaire   +3 more sources

The prognostic significance of CCL2 in oral squamous cell carcinoma: insights from tissue expression and perioperative serum profiling [PDF]

Frontiers in Oncology
ObjectiveThis study aims to examine the expression patterns of chemokine CCL2 in oral squamous cell carcinoma tissues, adjacent tissues and tumor microenvironment, including the examine of the paraffin block and the examination of the peripheral blood ...
Senli Wen, Senli Wen, Haolei Tan
doaj   +2 more sources

p53 is an Important Regulator of CCL2 Gene Expression [PDF]

Current Molecular Medicine, 2012
The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 that may play a role in various diseases. A recent study has indicated that the knockdown of human p53 leads to a strong negative regulation of CCL2 induction. We are therefore interested in how p53 regulates CCL2 gene expression.
X, Tang, M, Asano, A, O'Reilly, A, Farquhar, Y, Yang, S, Amar   +5 more
openaire   +3 more sources

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

Journal of Neuroinflammation, 2012
Background A brief exposure to systemic hypoxia (i.e., hypoxic preconditioning; HPC) prior to transient middle cerebral artery occlusion (tMCAo) reduces infarct volume, blood-brain barrier disruption, and leukocyte migration.
Stowe Ann M, Wacker Bradley K, Cravens Petra D, Perfater Jennifer L, Li Min K, Hu Ruilong, Freie Angela B, Stüve Olaf, Gidday Jeffrey M   +8 more
doaj   +2 more sources

Targeting the CCL2–CCR2 axis for atheroprotection

European Heart Journal, 2022
AbstractDecades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for lowering residual vascular risk.
Marios K Georgakis, Jürgen Bernhagen, Laura H Heitman, Christian Weber, Martin Dichgans   +4 more
openaire   +5 more sources

CCL2/CCR2 signaling in cancer pathogenesis [PDF]

Cell Communication and Signaling, 2020
AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao, Jaydutt V. Vadgama, Piwen Wang   +2 more
openaire   +3 more sources

CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. [PDF]

, 2009
BACKGROUND Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M.
Hussain Rabia, Cliff, Jacqueline M., Hasan, Z, Jamil, Bushra, Bushra Jamil, Hussain, Rabia, Cliff, Jacqueline M, Ashraf Mussarat, Hazel M Dockrell, Hasan Zahra, Jamil, B, Mussarat Ashraf, Jacqueline M Cliff, Ashraf, Mussarat, Cliff Jacqueline M., Cliff, JM, Irfan, Muhammad, Irfan Muhammad, Ashraf, M, Hussain, R, Muhammad Irfan, Hasan, Zahra, Dockrell Hazel M., Dockrell, HM, Irfan, M, Jamil Bushra, Dockrell, Hazel M, Rabia Hussain, Zahra Hasan   +28 more
core   +1 more source

The Role of Serum CC-Chemokine Ligand 2 (CCL2) in Obesity: A Comparative Study with Normal Subjects [PDF]

BIO Web of Conferences
Excess fat in the visceral area in the form of obesity is associated with metabolic syndrome. Various factors have been identified that contribute to the pathophysiology of obesity-related metabolic diseases, including chronic inflammatory factors and ...
Lestarini Asri, Aryastuti Anak Agung Sri Agung, Witari Ni Putu Diah, Dewi Ni Wayan Erly Sintya   +3 more
doaj   +1 more source