Results 11 to 20 of about 107,958 (309)

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]

Clinical and Translational Allergy, 2020
AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur, Marusa Rihar, Ana Koren, Matija Rijavec, Peter Kopac, Urska Bidovec-Stojkovic, Renato Erzen, Peter Korosec   +7 more
openaire   +3 more sources

Identification of a novel regulatory pathway for PPARα by RNA-seq characterization of the endothelial cell lipid peroxidative injury transcriptome [PDF]

Open Biology, 2019
Endothelial dysfunction caused by endothelial cell injuries is the initiating factor for atherosclerosis (AS), and lipid peroxidative injury is one of a dominant factor for AS pathogenesis.
Fangfang Dou, Beiling Wu, Lin Sun, Jiulin Chen, Te Liu, Zhihua Yu, Chuan Chen   +6 more
doaj   +1 more source

FGF19/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2.

Journal of Hepatology, 2023
BACKGROUND & AIMS Metastasis remains the major reason for high mortality of HCC patients. This study was designed to investigate the role of E-twenty-six-specific sequence variant 4 (ETV4) in promoting HCC metastasis and explored new combination therapy ...
Meng Xie, Zhuoying Lin, Xiaoyu Ji, Xiangyuan Luo, Zerui Zhang, Mengyu Sun, Xiaoping Chen, Bi-xiang Zhang, Hui-fang Liang, Danfei Liu, Yangyang Feng, Yijun Wang, Yiwei Li, Bifeng Liu, Wenjie Huang, L. Xia   +15 more
semanticscholar   +1 more source

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Cell Proliferation, 2021
The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms.
Maosen Xu, Yang Wang, Ruolan Xia, Yuquan Wei, Xiawei Wei   +4 more
semanticscholar   +1 more source

CCL2: An important cytokine in normal and pathological pregnancies: A review

Frontiers in Immunology, 2023
C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response.
Zhi Lin, Jiantao Shi, Min Chen, Zi-Meng Zheng, Ming-qing Li, Jun Shao   +5 more
semanticscholar   +1 more source

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

Cellular & Molecular Immunology, 2023
Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was isolated from the culture supernatants of not only mitogen-activated ...
T. Yoshimura, Chunning Li, Yuze Wang, A. Matsukawa   +3 more
semanticscholar   +1 more source

STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury

Journal of Translational Medicine, 2023
Background Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding of the underlying mechanisms of RILI is essential for the development of effective prevention and ...
J. Ni, T. Guo, Yue Zhou, Shanshan Jiang, Long Zhang, Zhengfei Zhu   +5 more
semanticscholar   +1 more source

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+/CX3CR1+ M-MDSCs into the tumor microenvironment in a redundant manner

Frontiers in Immunology, 2023
Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs, C. Kreiger, Defang Luo, Guimei Tian, Julia S. Garcia, L. Deleyrolle, Duane A. Mitchell, Jeffrey K. Harrison   +7 more
semanticscholar   +1 more source

Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy

International Journal on Biological Sciences, 2023
Rheumatoid arthritis (RA) is a prototypic inflammatory disease, characterized by the infiltration of proinflammatory cytokines into the joint synovium and the migration of mononuclear cells into inflammatory sites.
Jun Chang, Shan-Chi Liu, Yen-You Lin, Xiukui He, Yi-Syuan Wu, Chen-Ming Su, Chun-Hao Tsai, Hsien-Te Chen, Y. Fong, Sung‐Lin Hu, Chien-Chung Huang, Chih-Hsin Tang   +11 more
semanticscholar   +1 more source

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

Frontiers in Immunology, 2022
The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease.
Haixia Zhang, Ke Yang, Feng Chen, Qianqian Liu, Jingyu Ni, W. Cao, Yunqing Hua, Feng He, Zhihao Liu, Lan Li, Guanwei Fan   +10 more
semanticscholar   +1 more source