Results 11 to 20 of about 106,788 (300)

Role of CCL2/MCP-1 in Islet Transplantation

Cell Transplantation, 2010
High levels of donor-derived CCL2 have been associated with poor islet allograft outcome in patients with type 1 diabetes. The aim of our work was to determine whether CCL2 secreted by the islet has independent proinflammatory effects that influence ...
Raffaella Melzi, Alessia Mercalli, Valeria Sordi, Elisa Cantarelli, Rita Nano, Paola Maffi, Giovanni Sitia, Luca G. Guidotti, Antonio Secchi, Ezio Bonifacio, Lorenzo Piemonti   +10 more
doaj   +7 more sources

Chemokines during anaphylaxis : the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]

Clinical and Translational Allergy, 2021
Background: The role of chemokines in anaphylaxis is unclear. Methods: We prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects.
Rijavec, Matija, Kopač, Peter, Eržen, Renato, Koren, Ana, Korošec, Peter, Bidovec, Urška, Vantur, Romana, Rihar, Maruša   +7 more
core   +5 more sources

IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation

Journal of Inflammation Research, 2022
Nadeem Akhter,1 Shihab Kochumon,1 Amal Hasan,1 Ajit Wilson,1 Rasheeba Nizam,2 Ashraf Al Madhoun,2,3 Fatema Al-Rashed,1 Hossein Arefanian,1 Fawaz Alzaid,2,4 Sardar Sindhu,1,3 Fahd Al-Mulla,1 Rasheed Ahmad1 1Immunology & Microbiology Department, Dasman ...
Akhter N, Kochumon S, Hasan A, Wilson A, Nizam R, Al Madhoun A, Al-Rashed F, Arefanian H, Alzaid F, Sindhu S, Al-Mulla F, Ahmad R   +11 more
doaj   +1 more source

CCL2, CCR2 Gene Variants and CCL2, CCR2 Serum Levels Association with Age-Related Macular Degeneration

Life, 2022
Background: Age-related macular degeneration (AMD) is the most common cause of progressive and irreversible blindness in developed countries. Although the pathogenesis is not fully understood, AMD is a multifactorial pathology with an accumulation of ...
Alvita Vilkeviciute, Gedvilaite, Greta, Gaile Gudauskiene, Dalia Zaliuniene, Rasa Liutkeviciene, Gudauskiene, Gaile, Zaliuniene, Dalia, Greta Gedvilaite, Liutkeviciene, Rasa, Vilkeviciute, Alvita   +9 more
core   +4 more sources

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration [PDF]

Experimental Eye Research, 2013
Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been implicated in the pathogenesis of age-related macular degeneration.
Bainbridge, James W.B., Robbie, Scott J., Munro, Peter M.G., Cowing, Jill A., Jill A. Cowing, Yanai Duran, Peter M.G. Munro, Luhmann, Ulrich F.O., James W.B. Bainbridge, Duran, Yanai, Livia S. Carvalho, Scott J. Robbie, Ulrich F.O. Luhmann, Robin R. Ali, Carvalho, Livia S., Ali, Robin R.   +15 more
core   +3 more sources

Stimulation of CCL2 (MCP-1) and CCL2 mRNA by substance P in LAD2 human mast cells.

Translational Research, 2009
Chemokines are cytokines with chemotactic properties on inflammatory cells and other cell types. Chemokine (C-C motif) ligand 2 (CCL2), which is also called monocyte chemotactic protein 1 (MCP-1), is a potent chemotactic molecule that attracts ...
Ciampoli C, Conti P, Theoharides TC, Castellani ML, ANTINOLFI, PIERLUIGI, Vecchiet J, Cuccurullo C, Teté S, Boscolo P., Felaco M, CERULLI, Giuliano Giorgio, Salini V, CARAFFA, Auro   +12 more
core   +7 more sources

CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. [PDF]

, 2009
BACKGROUND Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M.
Hussain Rabia, Cliff, Jacqueline M., Hasan, Z, Jamil, Bushra, Bushra Jamil, Hussain, Rabia, Cliff, Jacqueline M, Ashraf Mussarat, Hazel M Dockrell, Hasan Zahra, Jamil, B, Mussarat Ashraf, Jacqueline M Cliff, Ashraf, Mussarat, Cliff Jacqueline M., Cliff, JM, Irfan, Muhammad, Irfan Muhammad, Ashraf, M, Hussain, R, Muhammad Irfan, Hasan, Zahra, Dockrell Hazel M., Dockrell, HM, Irfan, M, Jamil Bushra, Dockrell, Hazel M, Rabia Hussain, Zahra Hasan   +28 more
core   +5 more sources

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

Journal of Neuroinflammation, 2012
Background A brief exposure to systemic hypoxia (i.e., hypoxic preconditioning; HPC) prior to transient middle cerebral artery occlusion (tMCAo) reduces infarct volume, blood-brain barrier disruption, and leukocyte migration.
Stowe Ann M, Wacker Bradley K, Cravens Petra D, Perfater Jennifer L, Li Min K, Hu Ruilong, Freie Angela B, Stüve Olaf, Gidday Jeffrey M   +8 more
doaj   +2 more sources

CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]

Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy, Borsig, Lubor, Heikenwalder, Mathias   +2 more
openaire   +4 more sources

Targeting the CCL2–CCR2 axis for atheroprotection

European Heart Journal, 2022
AbstractDecades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for lowering residual vascular risk.
Marios K Georgakis, Jürgen Bernhagen, Laura H Heitman, Christian Weber, Martin Dichgans   +4 more
openaire   +5 more sources