Results 31 to 40 of about 107,958 (309)

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Molecular Cancer, 2020
The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis ...
Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, W. Cui, X. Jia   +9 more
semanticscholar   +1 more source

CCL2: An Important Mediator Between Tumor Cells and Host Cells in Tumor Microenvironment

Frontiers in Oncology, 2021
Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME consists of a considerable number of macrophages and stromal cells that have been identified in multiple tumor types.
Jiakang Jin, Jinti Lin, Ankai Xu, Jianan Lou, Chao Qian, Xiu-mao Li, Yitian Wang, Wei Yu, Hui-min Tao   +8 more
semanticscholar   +1 more source

Expression of a Fungal Lectin in Arabidopsis Enhances Plant Growth and Resistance Toward Microbial Pathogens and a Plant-Parasitic Nematode

Frontiers in Plant Science, 2021
Coprinopsis cinerea lectin 2 (CCL2) is a fucoside-binding lectin from the basidiomycete C. cinerea that is toxic to the bacterivorous nematode Caenorhabditis elegans as well as animal-parasitic and fungivorous nematodes.
Aboubakr Moradi, Mohamed El-Shetehy, Mohamed El-Shetehy, Jordi Gamir, Tina Austerlitz, Paul Dahlin, Krzysztof Wieczorek, Markus Künzler, Felix Mauch   +8 more
doaj   +1 more source

A nerve injury–specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression

Journal of Clinical Investigation, 2022
Maladaptive changes of nerve injury–associated genes in dorsal root ganglia (DRGs) are critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding RNAs (lncRNAs) in regulating gene transcription.
Shibin Du, Shaogen Wu, Xiaozhou Feng, Bing Wang, Shangzhou Xia, Lingli Liang, Li Zhang, Gokulapriya Govindarajalu, Alex Bunk, Feni Kadakia, Qingxiang Mao, Xinying Guo, Huiyuan Zhao, Tolga Berkman, Tong Liu, Hong Li, J. Stillman, A. Bekker, S. Davidson, Y. Tao   +19 more
semanticscholar   +1 more source

The effect of C–C motif chemokine ligand 2 supplementation on in vitro maturation of porcine cumulus-oocyte complexes and subsequent developmental competence after parthenogenetic activation

Frontiers in Veterinary Science, 2023
Porcine embryos are used for a variety of applications. However, the maturation rate in vitro remains low, and novel in vitro maturation (IVM) techniques that facilitate the collection of mature oocytes are necessary.
Sohee Kim, Sohee Kim, Dongjin Oh, Dongjin Oh, Hyerin Choi, Hyerin Choi, Mirae Kim, Mirae Kim, Lian Cai, Lian Cai, Lian Cai, Ali Jawad, Ali Jawad, Zheng Haomiao, Zheng Haomiao, Joohyeong Lee, Joohyeong Lee, Eunhye Kim, Sang-Hwan Hyun, Sang-Hwan Hyun, Sang-Hwan Hyun   +20 more
doaj   +1 more source

The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials

International Journal of Molecular Sciences, 2022
C-C motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate inflammation.
Huixia Geng, Luna Chen, Jing Tang, Yi'ang Chen, Lai Wang   +4 more
semanticscholar   +1 more source

Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy

Zhongliu Fangzhi Yanjiu, 2019
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes.
LU Xiaomei, FU Jiejun
doaj   +1 more source

B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Cancer immunology research, 2021
A role of B7-H3 in M2 macrophage–mediated immunosuppression in ovarian cancer is demonstrated. The data reveal B7-H3′s potential as a therapeutic target to enhance antitumor responses in ovarian cancer, highlighting a differential role from other B7 ...
T. Miyamoto, R. Murakami, J. Hamanishi, Kenji Tanigaki, Y. Hosoe, N. Mise, S. Takamatsu, Yuka Mise, M. Ukita, Mana Taki, Koji Yamanoi, N. Horikawa, K. Abiko, K. Yamaguchi, T. Baba, N. Matsumura, M. Mandai   +16 more
semanticscholar   +1 more source

CCL2 at the crossroad of cancer metastasis [PDF]

JAK-STAT, 2013
Primary tumors can affect organ functions, either mechanically when they grow to a considerable size or via production of hormones. However, mortality of cancer patients is in most cases due to formation of secondary growths.(1) (,) (2) Consequently, various drugs are currently employed in clinical trials to impair specific steps of cancer metastasis ...
openaire   +2 more sources

HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy

OncoImmunology, 2019
Through whole-transcriptome profiling of HER2+ breast carcinomas (BCs), we previously showed that those sensitive to trastuzumab are addicted to this oncoprotein and are enriched in immune pathways, raising the hypothesis that HER2 itself regulates ...
Tiziana Triulzi, Luca Forte, Viola Regondi, Martina Di Modica, Cristina Ghirelli, Maria Luisa Carcangiu, Lucia Sfondrini, Andrea Balsari, Elda Tagliabue   +8 more
doaj   +1 more source