Results 31 to 40 of about 100,029 (302)
Journal of Neuroinflammation, 2022 Background Peripheral nerve injuries stimulate the regenerative capacity of injured neurons through a neuroimmune phenomenon termed the conditioning lesion (CL) response.
Aaron D. Talsma +3 more
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CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways
Osteoarthritis and Cartilage Open, 2021 Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson +4 more
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Seasonal variations in the atmospheric distribution of a reactive chlorine compound, tetrachloroethene (CCl2=CCl2) [PDF]
, 1995 Tropospheric mixing ratios of CCl2=CCl2 were measured at remote surface locations in the Pacific between 71°N and 47°S during September and December of 1989, and March and June of 1990. The observed gradient of decreasing concentrations from the northern
Wang, Charles J‐L +2 more
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Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis
Frontiers in Immunology, 2021 ObjectivesTo investigate vascular macrophage phenotype as well as vascular and peripheral chemokine (C-C motif) ligand 2 (CCL2) expression during different stages of disease progression in patients with Takayasu Arteritis (TA).MethodsIn this study, 74 ...
Xiufang Kong +10 more
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CCL2 Blockade Augments Cancer Immunotherapy [PDF]
Cancer Research, 2010 Abstract Altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have both direct and indirect immunoinhibitory effects.
Zvi G, Fridlender +11 more
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Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy
Zhongliu Fangzhi Yanjiu, 2019 Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes.
LU Xiaomei, FU Jiejun
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Frontiers in Immunology, 2023 IntroductionAquaporin-4 immunoglobulin G (AQP4-IgG)-induced astrocytes injury is a key mechanism in the pathogenesis of neuromyelitis spectrum disorder (NMOSD), and although CCL2 is involved, its specific role has not been reported.
Yupeng Wang +20 more
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, 2023 We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate control of CCL2 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire +1 more source
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy
OncoImmunology, 2019 Through whole-transcriptome profiling of HER2+ breast carcinomas (BCs), we previously showed that those sensitive to trastuzumab are addicted to this oncoprotein and are enriched in immune pathways, raising the hypothesis that HER2 itself regulates ...
Tiziana Triulzi +8 more
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Plasma Chemokine C-C Motif Ligand 2 as a Potential Biomarker for Prostate Cancer
Research and Reports in Urology, 2022 Martin Lund,1 Torben B Pedersen,1 Søren Feddersen,2,3 Louise D Østergaard,1,3 Charlotte A Poulsen,1 Christian Enggaard,2 Mads HA Poulsen,1,3 Lars Lund1,3 1Department of Urology, Odense University Hospital, Odense, Denmark; 2Department of Clinical ...
Lund M +7 more
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