Results 31 to 40 of about 106,788 (300)

Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis

Frontiers in Immunology, 2021
ObjectivesTo investigate vascular macrophage phenotype as well as vascular and peripheral chemokine (C-C motif) ligand 2 (CCL2) expression during different stages of disease progression in patients with Takayasu Arteritis (TA).MethodsIn this study, 74 ...
Xiufang Kong, Ming Xu, Ming Xu, Xiaomeng Cui, Lingying Ma, Huiyong Cheng, Jun Hou, Xiaoning Sun, Lili Ma, Lindi Jiang, Lindi Jiang   +10 more
doaj   +1 more source

Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways

Journal of Immunotoxicology, 2020
Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C–C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain ...
Thitima Kasemsuk, Suttinee Phuagkhaopong, Ruedeemars Yubolphan, Norapat Rungreangplangkool, Pornpun Vivithanaporn   +4 more
doaj   +1 more source

Seasonal variations in the atmospheric distribution of a reactive chlorine compound, tetrachloroethene (CCl2=CCl2) [PDF]

, 1995
Tropospheric mixing ratios of CCl2=CCl2 were measured at remote surface locations in the Pacific between 71°N and 47°S during September and December of 1989, and March and June of 1990. The observed gradient of decreasing concentrations from the northern
Wang, Charles J‐L, Rowland, F Sherwood, Blake, Donald R   +2 more
core   +1 more source

Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders

Frontiers in Immunology, 2023
IntroductionAquaporin-4 immunoglobulin G (AQP4-IgG)-induced astrocytes injury is a key mechanism in the pathogenesis of neuromyelitis spectrum disorder (NMOSD), and although CCL2 is involved, its specific role has not been reported.
Yupeng Wang, Yupeng Wang, Yupeng Wang, Yupeng Wang, Jiangping Bian, Jiangping Bian, Mengyuan Yao, Mengyuan Yao, Li Du, Li Du, Yun Xu, Haoxiao Chang, Haoxiao Chang, Hengri Cong, Yuzhen Wei, Wangshu Xu, Huabing Wang, Xinghu Zhang, Xingchao Geng, Linlin Yin, Linlin Yin   +20 more
doaj   +1 more source

CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes [PDF]

, 2022
The chemokine CCL2 participates in multiple neuroinflammatory processes, mainly through the recruitment of glial cells. However, CCL2 has also been proven to exert different types of actions on these cells, including the modification of their response to
García-Bueno, Borja, Borja García-Bueno, José L. M. Madrigal, Juan C. Leza, Gutiérrez, Irene L, Leza Cerro, Juan Carlos, Leza, Juan C, Muñoz Madrigal, José Luis, García Bueno, Borja, Caso, Javier R, Irene L. Gutiérrez, López Gutiérrez, Irene, Madrigal, José L M, Fabiana Novellino, Caso Fernández, Javier Rubén, Novellino, Fabiana, Javier R. Caso   +16 more
core   +1 more source

Control of CCL2 by NOD2.

, 2023
We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate control of CCL2 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Morphine stimulates CCL2 production by human neurons [PDF]

, 2006
Background Substances of abuse, such as opiates, have a variety of immunomodulatory properties that may influence both neuroinflammatory and neurodegenerative disease processes.
Hu Shuxian, Rock R Bryan, Peterson Phillip K, Sheng Wen S   +3 more
core   +1 more source

CCL2 disrupts the adherens junction: implications for neuroinflammation [PDF]

Laboratory Investigation, 2012
Alterations to blood-brain barrier (BBB) adhesion molecules and junctional integrity during neuroinflammation can promote central nervous system (CNS) pathology. The chemokine CCL2 is elevated during CNS inflammation and is associated with endothelial dysfunction. The effects of CCL2 on endothelial adherens junctions (AJs) have not been defined.
Roberts, Toni K., Eugenin, Eliseo A., Lopez, Lillie, Romero, Ignacio A., Weksler, Babette B., Couraud, Pierre-Olivier, Berman, Joan W.   +6 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source