Results 61 to 70 of about 106,788 (300)

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

MicroRNA-33 suppresses CCL2 expression in chondrocytes [PDF]

Bioscience Reports, 2016
CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via controlling the expression of a series of genes. How the CCL2 gene was regulated by miRNAs was still not fully elucidated. In the present study, we demonstrated that the
Wei, Meng, Xie, Qingyun, Zhu, Jun, Wang, Tao, Zhang, Fan, Cheng, Yue, Guo, Dongyang, Wang, Ying, Mo, Liweng, Wang, Shuai   +9 more
openaire   +2 more sources

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

Neoplasia: An International Journal for Oncology Research, 2014
The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor cells; thus, identifying the mechanisms regulating CCL2 release by these cells may enable the future design ...
Yaeli Lebel-Haziv, Tsipi Meshel, Gali Soria, Adva Yeheskel, Elad Mamon, Adit Ben-Baruch   +5 more
doaj   +1 more source

Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion. [PDF]

PLoS ONE, 2013
Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2) promotes malignant pleural effusion (MPE) formation in mice.
Antonia Marazioti, Chrysoula A Kairi, Magda Spella, Anastasios D Giannou, Sophia Magkouta, Ioanna Giopanou, Vassilios Papaleonidopoulos, Ioannis Kalomenidis, Linda A Snyder, Dimitrios Kardamakis, Georgios T Stathopoulos   +10 more
doaj   +1 more source

Analysis of CCL2 expression in embryonic tissues.

, 2019
A) Flow cytometric analysis of E12.5 total YS cells from CCL2-reporter mice showing i) a discrete CCL2-expressing population and ii) CD11b and F4/80 gating, demonstrating that this population is largely CD11bhiF4/80lo.
Kit Ming Lee (6751391), Gillian J. Wilson (201892), Gerard J. Graham (6751409), Robin Bartolini (6751403), Ayumi Fukuoka (6751397), Christopher A. H. Hansell (6751400), Laura Medina-Ruiz (6751406), Marieke Pingen (6751394)   +7 more
core   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Cellular distribution of C-C motif chemokine ligand 2 like immunoreactivities in frontal cortex and corpus callosum of normal and lipopolysaccharide treated animal

BMC Neuroscience, 2022
Background C-C motif chemokine ligand 2 (CCL2) is reported to be involved in the pathogenesis of various neurological and/or psychiatric diseases. Tissue or cellular expression of CCL2, in normal or pathological condition, may play an essential role in ...
Xue Shi, Xinrui Gong, Huangui Xiong, Jingdong Zhang   +3 more
doaj   +1 more source

CCL2 increases VCAM-1 expression.

, 2013
(A) Synovial fluid was obtained from normal (n = 12) or osteoarthritis patients (n = 11) and examined with ELISA for the expression of CCL2. (B) Human synovial fibroblasts were cultured for 48 h, and media were collected to measure CCL2 (n = 6).
Ming-Chih Chou (296999), Chin-Jung Hsu (114046), Chih-Hsin Tang (104506), Yu-Min Lin (296993), Yuan-Ya Liao (297791)   +4 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source