Results 81 to 90 of about 106,788 (300)

CCL2 Polymorphism in Drug-Resistant and Drug-Responsive Patients with Epilepsy in Isfahan, Iran

Medical Laboratory Journal, 2017
Background and objective: Approximately 50 million people worldwide (1% of the worldchr('39')s population) suffer from epilepsy. Among 700 thousand people with epilepsy in Iran, 20% have refractory epilepsy. Accumulation of leukocytes in patientschr('39')
Zahra Rahimi, Mansour Salehi, Abbas Dousti   +2 more
doaj  

CCL2-RFP expression in myeloid cells in the brain.

CCL2-RFP mice were injected with PBS as a control or infected with PRU strain T. gondii, and brains were harvested at 15 DPI. Immune cells from the brain homogenates were analyzed by flow cytometry, and the mean fluorescence intensity (MFI) of CCL2-RFP ...
Katherine Still (8431287), Tajie H. Harris (8357067), Stephanie B. Orchanian (17775980), Melissa B. Lodoen (7310258)   +3 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

CCL2-functionalized Composite Scaffolds Enhance Bone Regeneration via Synergy of Osteogenesis and Angiogenesis

European Cells & Materials
Background: Chemokine (C-C motif) ligand 2 (CCL2) enhances bone regeneration when integrated into a composite scaffold and show promise for clinical applications in persistent bone defects. Methods: A composite biodegradable scaffold was fabricated using
Zhen Liang, Xin Peng, He Pang, Haina Yang, Bin Xie, Chengshuo Huang, Zhanpeng Su, Bo Wei, Sien Lin   +8 more
doaj   +1 more source

Human glioma shows CCL2⁺ cells.

, 2012
(A) The 14 cases of glioma analyzed show CCL2 expression in the tumorigenic areas. Samples of gliomas were immunostained to detect the expression of CCL2. All 14 cases analyzed showed expression of CCL2 in the neoplasic areas.
Ana Perez-Vallés (185864), Maria-Trinidad Herrero (185875), Maria Angeles Carrillo-de Sauvage (185858), Carmen María Ros (185860), José M. Gallego-Sanchez (185865), Eduardo D. Martín (182320), Emiliano Fernández-Villalba (185868), Aurora Gómez (185859), Francisco Ros-Bernal (185861), Carlos Barcia Sr. (185870), Carlos Barcia Jr (185872)   +10 more
core   +1 more source

Targeting the CCL2-CCR2 signaling axis in cancer metastasis. [PDF]

, 2016
The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its association with the progression of cancer. Although first described as a chemotactic molecule with physiological roles in regulating inflammation, recent studies ...
Alex N. Gordon-Weeks, Lim, SY, Su Yin Lim, Muschel, Ruth J., Yuzhalin, AE, Gordon-Weeks, Alex N., Gordon-Weeks, AN, Muschel, RJ, Lim, Su Y., Yuzhalin, Arseniy E., Arseniy E. Yuzhalin, Ruth J. Muschel   +11 more
core   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]

, 2017
Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects ...
Laclau, Muriel, Godefroy, David, Maury-Brachet, Régine, Combadière, Christophe, Rakwal, Randeep, Bourdineaud, Jean-Paul, Gosselin, Romain-Daniel, Melik-Parsadaniantz, Stéphane, Yasutake, Akira, Fujimura, Masatake, Rostène, William   +10 more
core  

Association between CCL2 haplotypes and knee osteoarthritis

, 2012
We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls.
Hulin-Curtis, S L, Perry, MJ, Perry, M. J., Bidwell, JL, Bidwell, J. L., Hulin-Curtis, Sarah L, M. J. Perry, Hulin-Curtis, Sarah, Perry, M J, J. L. Bidwell, S. L. Hulin‐Curtis, Bidwell, J L   +11 more
core   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source