Results 71 to 80 of about 106,788 (300)

CCL2 Is a Negative Regulator of AMP-Activated Protein Kinase to Sustain mTOR Complex-1 Activation, Survivin Expression, and Cell Survival in Human Prostate Cancer PC3 Cells

Neoplasia: An International Journal for Oncology Research, 2009
CCL2 is a cytokine prevalent in the prostate cancer tumor microenvironment. Recently, we reported that CCL2 induces the mammalian target of rapamycin (mTOR) pathway to promote prostate cancer PC3 cell survival; however, the mechanism used by CCL2 to ...
Hernan Roca, Zachary S. Varsos, Kenneth J. Pienta   +2 more
doaj   +1 more source

Study on plasma CC chemokine ligand 2 level and its promoter region 2518A/G polymorphism in MS patients

European Journal of Inflammation, 2020
The increase of CC chemokine ligand 2 (CCL2) is associated with multiple sclerosis (MS), but the relationship between gene promoter region 2518A/G and the pathogenesis of MS is still not obvious.
Zenghui Fu, Yan Jiang, Jing Liu, Zaihong Lin, Yan Jin   +4 more
doaj   +1 more source

The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]

Toxicological Sciences, 2011
Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects.
Godefroy, D., Gosselin, R.D., Yasutake, A., Fujimura, M., Combadière, C., Maury-Brachet, R., Laclau, M., Rakwal, R., Melik-Parsadaniantz, S., Bourdineaud, J.P., Rostène, W.   +10 more
openaire   +3 more sources

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Cell Reports, 2017
C-C chemokine ligand 2 (CCL2) plays pivotal roles in tumor formation, progression, and metastasis. Although CCL2 expression has been found to be dependent on the nuclear factor (NF)-κB signaling pathway, the regulation of CCL2 production in tumor cells ...
Hirokazu Nakatsumi, Masaki Matsumoto, Keiichi I. Nakayama   +2 more
doaj   +1 more source

Modulatory effect of the Ccl2 locus genotype (Ccl2^+/+, Ccl2^+/−, Ccl2^−/−) on the appearance of autofluorescent fundus lesions in Crb1^RD8/RD8 mice.

, 2012
Quantification of number of autofluorescent lesions/fundus image and littermate (n = ) according to the Ccl2 genotype and in comparison to the parental strains (CCDKO and C57Bl/6 mice).
Hannah E. J. Armer (170322), Vy Luong (170324), Livia S. Carvalho (170326), Ulrich F. O. Luhmann (170305), Robert E. MacLaren (170328), James W. B. Bainbridge (170330), Frederick W. Fitzke (170329), Jill A. Cowing (170321), Peter M. G. Munro (170319), Robin R. Ali (170331), Clemens A. Lange (170311), Scott Robbie (170316)   +11 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Trichloroethylene, CHCl=CCl2.

Journal of Synthetic Organic Chemistry, Japan, 1990
トリクロロエチレンはアルコール, エーテル, ケトン, ガソリン等通常の有機溶剤と完全に混合し, 油脂類, グリースなどをよく溶解する。通常の使用条件下では引火・燃焼することのない不燃性溶剤である。
openaire   +2 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source