Results 71 to 80 of about 100,029 (302)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Cellular distribution of C-C motif chemokine ligand 2 like immunoreactivities in frontal cortex and corpus callosum of normal and lipopolysaccharide treated animal

BMC Neuroscience, 2022
Background C-C motif chemokine ligand 2 (CCL2) is reported to be involved in the pathogenesis of various neurological and/or psychiatric diseases. Tissue or cellular expression of CCL2, in normal or pathological condition, may play an essential role in ...
Xue Shi, Xinrui Gong, Huangui Xiong, Jingdong Zhang   +3 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Modulatory effect of the Ccl2 locus genotype (Ccl2^+/+, Ccl2^+/−, Ccl2^−/−) on the appearance of autofluorescent fundus lesions in Crb1^RD8/RD8 mice.

, 2012
Quantification of number of autofluorescent lesions/fundus image and littermate (n = ) according to the Ccl2 genotype and in comparison to the parental strains (CCDKO and C57Bl/6 mice).
Hannah E. J. Armer (170322), Vy Luong (170324), Livia S. Carvalho (170326), Ulrich F. O. Luhmann (170305), Robert E. MacLaren (170328), James W. B. Bainbridge (170330), Frederick W. Fitzke (170329), Jill A. Cowing (170321), Peter M. G. Munro (170319), Robin R. Ali (170331), Clemens A. Lange (170311), Scott Robbie (170316)   +11 more
core   +1 more source

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Cell Reports, 2017
C-C chemokine ligand 2 (CCL2) plays pivotal roles in tumor formation, progression, and metastasis. Although CCL2 expression has been found to be dependent on the nuclear factor (NF)-κB signaling pathway, the regulation of CCL2 production in tumor cells ...
Hirokazu Nakatsumi, Masaki Matsumoto, Keiichi I. Nakayama   +2 more
doaj   +1 more source

Study on plasma CC chemokine ligand 2 level and its promoter region 2518A/G polymorphism in MS patients

European Journal of Inflammation, 2020
The increase of CC chemokine ligand 2 (CCL2) is associated with multiple sclerosis (MS), but the relationship between gene promoter region 2518A/G and the pathogenesis of MS is still not obvious.
Zenghui Fu, Yan Jiang, Jing Liu, Zaihong Lin, Yan Jin   +4 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

CCL2-RFP expression in myeloid cells in the brain.

CCL2-RFP mice were injected with PBS as a control or infected with PRU strain T. gondii, and brains were harvested at 15 DPI. Immune cells from the brain homogenates were analyzed by flow cytometry, and the mean fluorescence intensity (MFI) of CCL2-RFP ...
Katherine Still (8431287), Tajie H. Harris (8357067), Stephanie B. Orchanian (17775980), Melissa B. Lodoen (7310258)   +3 more
core   +1 more source

Morphine stimulates CCL2 production by human neurons

, 2006
Background Substances of abuse, such as opiates, have a variety of immunomodulatory properties that may influence both neuroinflammatory and neurodegenerative disease processes.
Hu Shuxian, Rock R Bryan, Peterson Phillip K, Sheng Wen S   +3 more
core   +1 more source

CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes

, 2022
The chemokine CCL2 participates in multiple neuroinflammatory processes, mainly through the recruitment of glial cells. However, CCL2 has also been proven to exert different types of actions on these cells, including the modification of their response to
García-Bueno, Borja, Borja García-Bueno, José L. M. Madrigal, Juan C. Leza, Gutiérrez, Irene L, Leza Cerro, Juan Carlos, Leza, Juan C, Muñoz Madrigal, José Luis, García Bueno, Borja, Caso, Javier R, Irene L. Gutiérrez, López Gutiérrez, Irene, Madrigal, José L M, Fabiana Novellino, Caso Fernández, Javier Rubén, Novellino, Fabiana, Javier R. Caso   +16 more
core   +1 more source