Results 91 to 100 of about 106,788 (300)

The prognostic significance of CCL2 in oral squamous cell carcinoma: insights from tissue expression and perioperative serum profiling

Frontiers in Oncology
ObjectiveThis study aims to examine the expression patterns of chemokine CCL2 in oral squamous cell carcinoma tissues, adjacent tissues and tumor microenvironment, including the examine of the paraffin block and the examination of the peripheral blood ...
Senli Wen, Senli Wen, Haolei Tan
doaj   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

eLife, 2019
Cellular ESCRT machinery plays pivotal role in HIV-1 budding and release. Extracellular stimuli that modulate HIV-1 egress are currently unknown. We found that CCL2 induced by HIV-1 clade B (HIV-1B) infection of macrophages enhanced virus production ...
David O Ajasin, Vasudev R Rao, Xuhong Wu, Santhamani Ramasamy, Mario Pujato, Arthur P Ruiz, Andras Fiser, Anne R Bresnick, Ganjam V Kalpana, Vinayaka R Prasad   +9 more
doaj   +1 more source

CCL2/CCR2: push/pull for migration

Blood, 2009
In this issue of Blood , Luesink and colleagues report that in APL, the induction of massive production CC-chemokines (CCLs) and their receptors (CCRs) in APL cells by differentiating therapy with ATRA or ATO may play an important role in the development of the DS,[1][1] formerly known as ...
openaire   +3 more sources

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

CCL2 promotes EGFR-TKIs resistance in non-small cell lung cancer via the AKT-EMT pathway

Acta Biochimica et Biophysica Sinica
Acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) represents a primary cause of treatment failure in non-small cell lung cancer (NSCLC) patients.
Diao Yunlian, Huang Shibo, Liu Fangpeng, Liao Shu, Guan Chenxi, Xiong Xiaojian, Zhang Ping, Li Junyao, Zhang Wei, Ying Ying   +9 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Differential tissue and cellular distribution of chemokine C-C motif ligand 2 in grey/white matters of healthy and simian immunodeficiency virus infected monkey

Brain Research Bulletin
Previous studies have shown that CCL2 concentration is higher in cerebrospinal fluid than in plasma of health and human immunodeficiency virus (HIV) infected individuals, suggesting an extra source of CCL2 in brain.
Xue Shi, Jingdong Zhang, Huangying Zhao, Hongjun Li, Junyi Zhu, Huangui Xiong   +5 more
doaj   +1 more source