Results 101 to 110 of about 100,029 (302)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

, 2023
The authors identify a tumor-suppressing angiocrine function of CCL2 which is inhibited by tumor-derived adrenomedullin acting via its receptor on endothelial cells.
Roquid, K., Chen, M., Iring, A., Guenther, S., Nakayama, A., Weinstein, L., Strilic, B., Offermanns, S.   +7 more
core   +1 more source

Differential tissue and cellular distribution of chemokine C-C motif ligand 2 in grey/white matters of healthy and simian immunodeficiency virus infected monkey

Brain Research Bulletin
Previous studies have shown that CCL2 concentration is higher in cerebrospinal fluid than in plasma of health and human immunodeficiency virus (HIV) infected individuals, suggesting an extra source of CCL2 in brain.
Xue Shi, Jingdong Zhang, Huangying Zhao, Hongjun Li, Junyi Zhu, Huangui Xiong   +5 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Increased local expressions of CX3CL1 and CCL2 are related to clinical severity in lumbar disk herniation patients with sciatic pain

, 2017
Zhen-Yu Peng,1,2 Rui Chen,3 Zuo-Zhong Fang,2 Bin Chen,2 Zhi-Hua Wang,4 Xi-Yang Wang1 1Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, 2Department of Spine Surgery, Chenzhou No.1 People’s Hospital, Chenzhou ...
Peng ZY, Wang ZH, Fang ZZ, Chen R, Chen B, Wang XY   +5 more
core  

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile.

, 2014
10.4049/jimmunol.1302821The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression is upregulated by proinflammatory cytokines.
Sánchez-Torres, C., Nieto, C., Ardavín, C., Domínguez-Soto, A., Corbí, A.L., Rodríguez-Fernández, J.L., Sánchez-Mateos, P., Barroso, R., Joven, J., Puig-Kroger, A., Mellado, M., Sierra-Filardi, E., López-Bravo, M.   +12 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice

, 2010
Cerebral inflammation involves molecular cascades contributing to progressive damage after traumatic brain injury (TBI). The chemokine CC ligand-2 (CCL2) (formerly monocyte chemoattractant protein-1, MCP-1) is implicated in macrophage recruitment into ...
Rancan, M., Ziebell, J., Semple, B., Bye, N., Morganti-Kossmann, M.   +4 more
core   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Targeting the CCL2-CCR2 signaling axis in cancer metastasis.

, 2016
The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its association with the progression of cancer. Although first described as a chemotactic molecule with physiological roles in regulating inflammation, recent studies ...
Alex N. Gordon-Weeks, Lim, SY, Su Yin Lim, Muschel, Ruth J., Yuzhalin, AE, Gordon-Weeks, Alex N., Gordon-Weeks, AN, Muschel, RJ, Lim, Su Y., Yuzhalin, Arseniy E., Arseniy E. Yuzhalin, Ruth J. Muschel   +11 more
core   +1 more source