Results 51 to 60 of about 45,468 (163)

CCR2 Chemokine Receptor and AIDS Progression

, 1997
Recently we reported an association between the CCR2-64I chemokine receptor mutation and delayed onset of AIDS. Michael et al. have now examined the San Francisco Mens Health Study (SFMHS) AIDS cohort for CCR2 genotypes and in this issue of Nature ...
Lomb, Deborah A., O\u27Brien, Stephen J., Carrington, Mary, Smith, Michael W., Dean, Michael, Huttley, Gavin A., Winkler, Cheryl   +6 more
core   +2 more sources

Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. [PDF]

PLoS ONE, 2011
CCR2 is considered a proinflammatory mediator in many inflammatory diseases such as rheumatoid arthritis. However, mice lacking CCR2 develop exacerbated collagen-induced arthritis.
Rishi R Rampersad, Teresa K Tarrant, Christopher T Vallanat, Tatiana Quintero-Matthews, Michael F Weeks, Denise A Esserman, Jennifer Clark, Franco Di Padova, Dhavalkumar D Patel, Alan M Fong, Peng Liu   +10 more
doaj   +1 more source

The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells. [PDF]

PLoS ONE, 2017
Acute myeloid leukemia (AML) has a high mortality rate despite chemotherapy and transplantation. Both CXCR4/SDF-1 and VLA-4/VCAM1 axes are involved in leukemia protection but little is known about the role of CCL2/CCR2 in AML biology and protection ...
Patricia Macanas-Pirard, Thomas Quezada, Leonardo Navarrete, Richard Broekhuizen, Andrea Leisewitz, Bruno Nervi, Pablo A Ramírez   +6 more
doaj   +1 more source

Expression of CCR2 by AML patient samples.

, 2017
(A) Leukemia blasts purified from BM primary samples were analyzed for CCR2 expression by FCM. (B) Patient 2 BM FCM analysis (histogram) is shown as an example with 56% CCR2+ leukemia cells.
Patricia Macanas-Pirard (321945), Andrea Leisewitz (321948), Thomas Quezada (3611420), Bruno Nervi (321975), Richard Broekhuizen (321951), Pablo A. Ramírez (3611417), Leonardo Navarrete (3611414)   +6 more
core   +1 more source

Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltrationResearch in context

EBioMedicine
Summary: Background: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition.
Hasan Farooq, Hannah P. Luehmann, Jeffrey R. Koenitzer, Gyu Seong Heo, Deborah H. Sultan, Devesha H. Kulkarni, Sean P. Gunsten, Rekha M. Sashti, Tao Huang, Amanda R. Keller, Kory J. Lavine, Jeffrey J. Atkinson, Laura M. Wingler, Yongjian Liu, Steven L. Brody   +14 more
doaj   +1 more source

Cancer cell CCR2 orchestrates suppression of the adaptive immune response [PDF]

, 2018
C-C chemokine receptor type 2 (CCR2) is expressed on monocytes and facilitates their recruitment to tumors. Although breast cancer cells also express CCR2, its functions in these cells are unclear.
Yan, Ran, Bružas, Emilis, Fein, Miriam, He, Xue-Yan, Pommier, Arnaud, Van Aelst, Linda, dos Santos, Camila, Almeida, Ana, Fearon, Douglas, Egeblad, Mikala, Eberhardt, Anaïs, Wilkinson, John   +11 more
core   +1 more source

CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress.

PLoS ONE, 2019
CCL2/CCR2 signaling is believed to play an important role in kidney diseases. Several studies have demonstrated that blocking of CCR2 has a therapeutic effect on kidney diseases.
Seung Joo Lee, Jeong Suk Kang, Hong Min Kim, Eun Soo Lee, Ji-Hye Lee, Choon Hee Chung, Eun Young Lee   +6 more
doaj   +1 more source

CCR2 Deficiency Decreases Intimal Hyperplasia After Arterial Injury

, 2002
Monocyte chemoattractant protein (MCP)-1 is upregulated in atherosclerotic plaques and in the media and intima of injured arteries. CC chemokine receptor 2 (CCR2) is the only known functional receptor for MCP-1.
John T. Fallon, Michaela Gazdoin, Mark B. Taubman, Merce Roque, Ernane D. Reis, William J.H. Kim, Israel F. Charo, Juan J. Badimon, Alia Malik   +8 more
core   +1 more source

Targeting the CCL2-CCR2 signaling axis in cancer metastasis. [PDF]

, 2016
The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its association with the progression of cancer. Although first described as a chemotactic molecule with physiological roles in regulating inflammation, recent studies ...
Alex N. Gordon-Weeks, Lim, SY, Su Yin Lim, Muschel, Ruth J., Yuzhalin, AE, Gordon-Weeks, Alex N., Gordon-Weeks, AN, Muschel, RJ, Lim, Su Y., Yuzhalin, Arseniy E., Arseniy E. Yuzhalin, Ruth J. Muschel   +11 more
core   +1 more source

Cancer cell CCR2 orchestrates suppression of the adaptive immune response. [PDF]

, 2020
C-C chemokine receptor type 2 (CCR2) is expressed on monocytes and facilitates their recruitment to tumors. Though breast cancer cells also express CCR2, its functions in these cells are unclear. We found that Ccr2 deletion in cancer cells led to reduced
Fearon, Douglas T, Xue-Yan He, Anaïs Eberhardt, Bružas, Emilis, Camila O. dos Santos, John Erby Wilkinson, Fein, Miriam R, Almeida, Ana S, Ran Yan, Linda Van Aelst, Emilis Bružas, Eberhardt, Anaïs, Arnaud Pommier, Mikala Egeblad, Yan, Ran, Douglas T. Fearon, Dos Santos, Camila O, He, Xue-Yan, Pommier, Arnaud, Van Aelst, Linda, Egeblad, Mikala, Miriam R. Fein, Wilkinson, John Erby, Ana S. Almeida   +23 more
core   +1 more source