Results 71 to 80 of about 45,468 (163)

CCR2 CC5 and SDF1 antagonist.pdf

, 2016
CCR2 CC5 and SDF1 ...
Ranjeet Singh Mahla (2854859)
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Role of CCR2 in orthodontic tooth movement

, 2012
Introduction: Cytokines and chemokines regulate bone remodeling during orthodontic tooth movement. CC chemokine ligand 2 (CCL2) is involved in osteoclast recruitment and activity, and its expression is increased in periodontal tissues under mechanical ...
Garlet, Gustavo Pompermaier, Taddei, Silvana Rodrigues de Albuquerque, Cunha, Fernando de Queiroz, Garlet, Thiago Pompermaier, Andrade, Ildeu, Jr., Queiroz-Junior, Celso Martins, Teixeira, Mauro Martins, Silva, Tarcilia Aparecida da   +7 more
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Synergy-inducing chemokines enhance CCR2 ligand activities on monocytes

, 2009
The migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells ...
B.O. Gerber, V. Petkovic, Petkovic, Vibor, Luisa Stefano, Danelon, Gabriela, K. Kuscher, Locati, Massimo, M. Schiraldi, Basil O. Gerber, Stefano, Luisa, L. Stefano, Gabriela Danelon, Samantha Paoletti, Kuscher, Katrin, Uguccioni, Mariagrazia, S. Paoletti, Milena Schiraldi, Paoletti, Samantha, Gerber, Basil O, G. Danelon, Mariagrazia Uguccioni, M. Uguccioni, Vibor Petkovic, Massimo Locati, Katrin Kuscher, M. Locati, Schiraldi, Milena   +26 more
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Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

Molecular Pain, 2010
Background The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains poorly ...
Vaillancourt François, Lembo Paola MC, Lessard Etienne, Jomphe Claudia, Martino Giovanni, Elmes Steven JR, McIntosh Fraser, Paré Michel, Serrano Alexandre, Perkins Martin N, Cao Chang   +10 more
doaj   +1 more source

CCR2 deficiency reduces profibrotic chemokine production.

, 2013
A. CCR2 deficiency inhibits MCP-1 and CXCL16 gene expression in the kidneys 7 days after UUO. The mRNA levels of MCP-1 and CXCL16 in the kidneys of WT and CCR2-KO mice are determined by real-time RT-PCR.
Yanlin Wang (110566), Yunfeng Xia (314202), Mark L. Entman (107399)   +2 more
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Cloning and functional characterization of the rabbit C-C chemokine receptor 2

BMC Immunology, 2005
Background CC-family chemokine receptor 2 (CCR2) is implicated in the trafficking of blood-borne monocytes to sites of inflammation and is implicated in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, multiple sclerosis ...
Hamdouchi Chafiq, Su Eric W, Wang He, Pappas Amy T, Evans Robert J, Yuan Xiu-juan, Lu Deshun, Venkataraman Chandrasekar   +7 more
doaj   +1 more source

In vitro and in vivo functionality of introduced CCR2.

, 2013
(A) CCR2-transduced Jurkat cells, but not parental Jurkat cells, displayed dose-dependent transwell CCL2-chemotaxis. The numbers of cells migrating are shown relative to that at a CCL2 concentration of 12.5 ng/mL. Error bars represent SDs. (B) Similarly,
Kozo Nagai (236221), Hiroshi Fujiwara (236227), Kiyotaka Kuzushima (127879), Masaki Yasukawa (28387), Junichi Mineno (15939), Yukihiro Miyazaki (283052), Hiroshi Shiku (190949), Toshiki Ochi (236237), Sachiko Okamoto (15940), Hirofumi Inoue (283053), Hiroaki Asai (283051), Jun An (236233)   +11 more
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CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis

Journal of Neuroinflammation
Central nervous system (CNS) resident memory CD8 T cells (TRM) that express IFN-γ contribute to neurodegenerative processes, including synapse loss, leading to memory impairment.
Shenjian Ai, Artem Arutyunov, Joshua Liu, Jeremy D. Hill, Xiaoping Jiang, Robyn S. Klein   +5 more
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Regulation of CCR2 chemokine receptor mRNA stability

, 1997
During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels
D J Kelvin, C Kong, L Xu, L Ran, A Biragyn, M Devries, J-M Wang, R Rahimpour, J Andrews   +8 more
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A MCP1 fusokine with CCR2-specific tumoricidal activity [PDF]

, 2011
Background The CCL2 chemokine is involved in promoting cancer angiogenesis, proliferation and metastasis by malignancies that express CCR2 receptor. Thus the CCL2/CCR2 axis is an attractive molecular target for anticancer drug development.
Kathy Forner, Marie-Noëlle Boivin, Rafei Moutih, Lawrence H Boise, Craig Castellino, Deng Jiusheng, Williams Patrick, Jacques Galipeau, Boise Lawrence H, Tobey J MacDonald, Shannon M Matulis, Forner Kathy, Boivin Marie-Noëlle, Jiusheng Deng, Yuan Shala, Moutih Rafei, Yuan Liangping, Elena Birman, Birman Elena, Matulis Shannon M, Galipeau Jacques, Shala Yuan, Patrick Williams, Castellino Craig, MacDonald Tobey J, Liangping Yuan   +25 more
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