Results 71 to 80 of about 37,429 (252)
PLoS ONE, 2019 CCL2/CCR2 signaling is believed to play an important role in kidney diseases. Several studies have demonstrated that blocking of CCR2 has a therapeutic effect on kidney diseases.
Seung Joo Lee +6 more
doaj +1 more source
CCL2/CCR2: push/pull for migration
Blood, 2009 In this issue of Blood , Luesink and colleagues report that in APL, the induction of massive production CC-chemokines (CCLs) and their receptors (CCRs) in APL cells by differentiating therapy with ATRA or ATO may play an important role in the development of the DS,[1][1] formerly known as ...
openaire +3 more sources
Blockade of CCR2 Ameliorates Progressive Fibrosis in Kidney [PDF]
The American Journal of Pathology, 2004 Fibrosis is a hallmark of progressive organ diseases. Monocyte chemoattractant protein (MCP)-1, also termed as macrophage chemotactic and activating factor (MCAF/CCL2) and its receptor, CCR2 are presumed to contribute to progressive fibrosis. However, the therapeutic efficacy of MCP-1/CCR2 blockade in progressive fibrosis remains to be investigated. We
Kiyoki, Kitagawa +10 more
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Advanced Science, EarlyView.PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu +17 more
wiley +1 more source
CCR2 and coronary artery disease: a woscops substudy [PDF]
BMC Research Notes, 2010 Several lines of evidence support a role for CCL2 (monocyte chemotactic protein-1) and its receptor CCR2 in the development of atherosclerosis. The aim of the present study was to determine the association of the CCR2 Val64Ile polymorphism with the development of coronary artery disease in the WOSCOPS study sample set.A total of 443 cases and 1003 ...
Gray Ian C +4 more
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Advanced Science, EarlyView.Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng +17 more
wiley +1 more source
Frontiers in Oncology, 2019 Objective: The present study investigated the roles and underlying mechanism of CCL2/CCR2 axis in the interactions between tumor cells and tumor-associated macrophages (TAMs) during the progression of salivary adenoid cystic carcinoma (SACC).Methods ...
Zihui Yang +9 more
doaj +1 more source
From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance
Advanced Science, EarlyView.Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu +6 more
wiley +1 more source
Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
Inflammatory monocytes orchestrate innate antifungal immunity in the lung.
PLoS Pathogens, 2014 Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (IA) in immunocompromised patients. Although -CC-chemokine receptor-2 (CCR2) and Ly6C-expressing inflammatory monocytes (CCR2⁺Mo) and their derivatives initiate adaptive ...
Vanessa Espinosa +11 more
doaj +1 more source