Results 91 to 100 of about 45,468 (163)

Molecular modeling of human CCR2 receptor within POPC lipid bilayer.

Chemokine receptor 2 (CCR2), a G-protein coupled receptor (GPCR), is a critical target for several inflammatory and autoimmune diseases. The main restriction on designing desirable antagonists against CCR2 is the lack of appropriate crystal structure for
عبادی, احمد, کریمی, ادیبه, دستان, دارا, رزاقی اصل, نیما, اعظمی, مجتبی   +4 more
core   +1 more source

Blockade of CC chemokine receptor 2 suppresses pancreatic cancer progression through the interaction with macrophages in the tumor microenvironment

Scientific Reports
Pancreatic ductal adenocarcinoma (PDAC) is the most intractable cancer, demonstrating abundant stroma in the tumor microenvironment (TME). Previously, we reported that CXC chemokines contributed to the progression of PDAC through tumor-stromal ...
Gen Kimura, Hideaki Ijichi, Makoto Sano, Genso Notoya, Koji Miyabayashi, Ryota Takahashi, Takahiro Kishikawa, Mitsuhiro Fujishiro   +7 more
doaj   +1 more source

Age-related IGF-1 decline permits a redox-sensitive transcriptional shift that directs hematopoiesis toward a CCR2⁺ myeloid fate. [PDF]

Redox Biol
Chen Z, Fu X, Liu C, Jiang W, Liu J, Hao M, Fu L, Huang W, Lang X, Liu X, Liu Y, Li H, Li R, Sun B.   +13 more
europepmc   +1 more source

Discovery of a CCR2-targeting pepducin therapy for chronic pain

Targeting the CCL2/CCR2 chemokine axis has been shown to be effective at relieving pain in rodent models of inflammatory and neuropathic pain, therefore representing a promising avenue for the development of non-opioid analgesics.
Philippe Sarret, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Éric Marsault, Christine E. Mona, Élora Midavaine, Jérôme Côté, Elizabeth Théberge, Sakeen W. Kashem, Vera Zeugin   +10 more
core   +1 more source

An Integrated Multi-Tissue Single-Cell Transcriptomic Analysis Highlights the CCL2-CCR2 Signaling Pathway as a Potential Therapeutic Target in Neuropathic Pain. [PDF]

J Pain Res
Gan X, Wang K, Lu D, Tang H, Xie J, Tan L, Pang J.   +6 more
europepmc   +1 more source

Macrophage-Rich Peritoneal Compartments and CCR2-Dependent Hematopoietic Recruitment Are Differentially Associated with Adhesion Formation After Abdominal Surgery. [PDF]

Biomedicines
Woestemeier A, Lysson M, Braun L, Jafari A, Lingohr P, Wehner S, Kalff JC, Hong GS.   +7 more
europepmc   +1 more source

Immunometabolic regulation of cardiac macrophages in heart failure with preserved ejection fraction. [PDF]

Front Immunol
Liang J, Su M, Liu R, Li T, Qin Z, Wang Y.   +5 more
europepmc   +1 more source

Recruited Monocyte-Derived Macrophages Drive T Cell Inflammation in Immune Checkpoint Inhibitor-Mediated Pneumonitis. [PDF]

Cancer Commun (Lond)
Cui X, Zhi R, Li X, Ji Y, Hu Z, Cui P, Qin Y, Li T, Wu L, Wang L, Li J, Bai Y, Li H, Liu T, Hu Y.   +14 more
europepmc   +1 more source

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser-Induced Lesions. [PDF]

Glia
Wagner J, Antony H, Hoyer C, Lundgrén K, Soliymani R, Crux S, Justus L, Keppler K, Steffen J, Kurts C, Engel DR, Herms J, Łałowski M, Fuhrmann M.   +13 more
europepmc   +1 more source

Early CCR2-dependent monocyte recruitment defines a critical neuroinflammatory window after subarachnoid hemorrhage. [PDF]

Front Immunol
Kang DS, Seok SH, Lee SH, Na YR.
europepmc   +1 more source