Results 81 to 90 of about 45,468 (163)

MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

Scientific Reports
Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematological malignancy with restricted effective therapy choices. Neither the recruitment of monocytes nor the functioning of the physiological mechanisms of macrophage polarization can be achieved
Zhao-Feng Wen, Qi-Tang Huang, Yang-Yang Wang, Feng-Ya Nan, Zhi-Min Zhai, Yan-Li Li   +5 more
doaj   +1 more source

Virus restriction gene variants and their possible role in neurocognitive function in children born to HIV-infected mothers [PDF]

, 2012
Includes abstract.Includes bibliographical references.Host genetic variation is an important determinant of HIV infection, disease progression and HIV-associated neurocognitive deficits.
Mhandire, Kudakwashe
core  

Expression of CCR2 by Endothelial Cells

, 1999
—Endothelial cell proliferation and migration may play a central role in angiogenesis, wound healing, and atherosclerosis. Although CXC chemokines can act on endothelial cells by influencing proliferation, an involvement of CC chemokines and endothelial ...
Kim S. C. Weber, Peter J. Nelson, Hermann-Joseph Gröne, Christian Weber   +3 more
core   +1 more source

CCR2/CCR5 Haplotypes and abridged phylogenetic tree.

, 2013
Haplotypes were constructed based on the evolution of linked CCR2 and CCR5 mutations, including a valine to isoleucine substitution at codon 64 in the CCR2b gene (CCR2-64I), CCR5 mutations -2733A→G, -2554 G→T, -2459A→G, -2135C→T, -2132C→T, -2086A→G ...
Stephen J. Rogerson (34036), Melinda Blood (34033), Bonnie R. Pedersen (34031), Steven R. Meshnick (34038), Peter Zimmerman (34037), Victor Mwapasa (34034), Malcolm Molyneux (1711), Deborah Kamwendo (34032), Kari North (34035)   +8 more
core   +1 more source

CCR2-positive cells can be mobilized by CXCR4 inhibition.

, 2015
CCR2::CCR2-EGFP mice were injected with AMD3100 or saline, and the percentage of EGFP-positive cells in the bone marrow or in the blood was measured by flow cytometry.
Hosung Jung (748182), Divakar S. Mithal (748183), Richard J. Miller (227992), Jeong Eun Park (166868)   +3 more
core   +1 more source

Modulation of CCR2/CCL2 molecular axis in the expansion and rupture of abdominal aortic aneurysms

Frontiers in Cardiovascular Medicine
The CCR2/CCL2 molecular axis is a critical mediator of abdominal aortic aneurysm (AAA) pathogenesis. It has been demonstrated to drive chronic inflammation, extracellular matrix degradation, and vascular remodeling through the recruitment and activation ...
Ryan Wahidi, Ryan Wahidi, Santiago Elizondo-Benedetto, Ryan Catlett, Bera Koklu, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed   +11 more
doaj   +1 more source

Targeting of Gr‐1+,CCR2+ monocytes in collagen‐induced arthritis

, 2007
Objective. The chemokine receptor CCR2 is highly expressed on monocytes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with a monoclonal antibody (mAb) during progression of collagen -induced arthritis ...
Bruno Luckow, Leoni Kunz‐Schughart, Yvonne Talke, Talke, Yvonne, Marianne Niedermeier, Hilke Brühl, Rodriguez Gomez, Manuel, Cihak, Josef, Luckow, Bruno, Brühl, Hilke, Plachý, Jiří, Manuel Rodriguez Gomez, Andrea Denzel, Jiří Plachý, Manfred Stangassinger, Denzel, Andrea, Kunz‐Schughart, Leoni, Stangassinger, Manfred, Mack, Matthias, Josef Cihak, Niedermeier, Marianne, Matthias Mack   +21 more
core   +1 more source

Modulating Macrophage Polarization through CCR2 Inhibition and Multivalent Engagement

, 2018
Excessive or prolonged recruitment of inflammatory monocytes to damaged tissue can significantly worsen patient outcomes. Monocytes migrate to sites of tissue inflammation in response to high local concentrations of CCL2, a chemokine that binds to and ...
Juliane Nguyen (2002057), Michael B. Deci (5333888), Scott W. Ferguson (5333882), Sydney L. Scatigno (5333885)   +3 more
core   +1 more source

A subset of NK cells expresses the CCR2 receptor.

, 2013
(A) Gating strategy (upper panel) for NK cells (TCRβ−NK1.1+DX5+) and representative histograms (lower panel) showing CCR2 expression on NK cells recovered from the indicated organs (blood, lung, BM and spleen) of naïve C57BL/6 (wt) or CCR2−/− mice. (B,C)
Dietmar M. W. Zaiss (294341), Mary J. G. van Helden (294340), Alice J. A. M. Sijts (181445)   +2 more
core   +1 more source

P02 | THE C-C CHEMOKINE-RECEPTOR 2 (CCR2)/CCL2 AXIS PARTICIPATE IN PLATELET FUNCTION IN MYELOFIBROSIS

European Journal of Histochemistry
Myelofibrosis (MF) is the most severe myeloproliferative neoplasm driven by mutations of the MPL/JAK2 axis induced by megakaryocytes (MKs) with reduced GATA1 content1.
doaj   +1 more source