Results 61 to 70 of about 45,468 (163)

CCL2/CCR2 Axis Promotes the Progression of Salivary Adenoid Cystic Carcinoma via Recruiting and Reprogramming the Tumor-Associated Macrophages

Frontiers in Oncology, 2019
Objective: The present study investigated the roles and underlying mechanism of CCL2/CCR2 axis in the interactions between tumor cells and tumor-associated macrophages (TAMs) during the progression of salivary adenoid cystic carcinoma (SACC).Methods ...
Zihui Yang, Huan Li, Weiqi Wang, Jianying Zhang, Sen Jia, Jun Wang, Jianhua Wei, Delin Lei, Kaijin Hu, Xinjie Yang   +9 more
doaj   +1 more source

CCR2 mediated recruitment of aberrant myeloid compartment and high CCR2 and CCR5 ligands.

, 2022
Left: Diagrammatic summary representation of CCR2- and CCR5-mediated recruitment of aberrant myeloid compartment via elevated airway CCR2 and CCR5 agonist ligand expression in airways of patients with severe COVID-19 infection.
William G. Powderly (12936620), Alexandra O’Sullivan (12936611), Patrick Dorr (12936614), Frank Tacke (170575), Daniel Clark Files (12936608), William G. Ferguson (12936617)   +5 more
core   +1 more source

Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction

, 2018
Jinli Wang,1,2,* Min Jeong Seo,1,* Michael B Deci,1 Brian R Weil,3 John M Canty,3,4 Juliane Nguyen1,2 1Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, The State University of New York, Buffalo, NY, USA; 2Department of ...
Seo MJ, Canty JM, Deci MB, Wang J, Nguyen J, Weil BR   +5 more
core  

CCR2–/–embryos phenocopy ACKR2–/–embryos.

, 2019
A) CCR2 expression is higher in the intermediate compared to the monocyte population of cells. These data represent raw counts of CCR2 expression from the bulk RNA sequencing data.
Kit Ming Lee (6751391), Gillian J. Wilson (201892), Gerard J. Graham (6751409), Robin Bartolini (6751403), Ayumi Fukuoka (6751397), Christopher A. H. Hansell (6751400), Laura Medina-Ruiz (6751406), Marieke Pingen (6751394)   +7 more
core   +1 more source

Inflammatory monocytes orchestrate innate antifungal immunity in the lung.

PLoS Pathogens, 2014
Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (IA) in immunocompromised patients. Although -CC-chemokine receptor-2 (CCR2) and Ly6C-expressing inflammatory monocytes (CCR2⁺Mo) and their derivatives initiate adaptive ...
Vanessa Espinosa, Anupam Jhingran, Orchi Dutta, Shinji Kasahara, Robert Donnelly, Peicheng Du, Jeffrey Rosenfeld, Ingrid Leiner, Chiann-Chyi Chen, Yacov Ron, Tobias M Hohl, Amariliz Rivera   +11 more
doaj   +1 more source

CCR5/CCR2 heterodimer interfaces.

, 2018
a Populations of CCR5/CCR2 chemokine receptor heterodimers after 3 μs in pure POPC membranes (light colors), and after 8 μs in POPC membranes containing 30% cholesterol (dark colors).
Rainer A. Böckmann (330653), Kristyna Pluhackova (1847899), Stefan Gahbauer (3331956)   +2 more
core   +1 more source

CCR2 and coronary artery disease: a woscops substudy [PDF]

, 2010
Background Several lines of evidence support a role for CCL2 (monocyte chemotactic protein-1) and its receptor CCR2 in the development of atherosclerosis.
Dow David J, Pieter HE Groot, Packard, C.J., Dow, D.J., Alex D McMahon, McMahon, A.D., Chris J Packard, McMahon Alex D, Ian C Gray, David J Dow, Packard Chris J, Gray, I.C., Groot, P.H.E., Gray Ian C, Groot Pieter HE   +14 more
core   +1 more source

Silencing of CCR2 in myocarditis

, 2019
Background: Myocarditis is characterized by inflammatory cell infiltration of the heart and subsequent deterioration of cardiac function. Monocytes are the most prominent population of accumulating leucocytes.
Katus, Hugo, Meyer, Soeren, Weissleder, Ralph, Swirski, Filip, Borodovsky, Anna, Gorbatov, Rostic, Anderson, Daniel, Mortensen, Luke, Dutta, Partha, Fitzgerald, Kevin, Koteliansky, Victor, Libby, Peter, Courties, Gabriel, Lasitschka, Felix, Sena, Brena, Iwamoto, Yoshiko, Nahrendorf, Matthias, Bohlender, Marina, Leuschner, Florian, Novobrantseva, Tatiana, Lin, Charles, Meder, Benjamin   +21 more
core   +1 more source

The chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis [PDF]

, 2017
Thymic dendritic cells (DC) play a role in central tolerance. Three thymic DC subtypes have been described: plasmacytoid DC (pDC) and two conventional DC (cDC), CD8α+ Sirpα- DC and Sirpα+ CD8α- cDC.
Frank, Ida, Cédile, Oriane, Østerby Jørgensen, Line, Ida Frank, Owens, Trevor; id_orcid, Agnieszka Wlodarczyk, Wlodarczyk, Agnieszka, Oriane Cédile, Line Østerby Jørgensen, Trevor Owens   +9 more
core   +1 more source

Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function

Journal of Lipid Research, 1999
Monocytes are recruited from the circulation into the subendothelial space where they differentiate into mature macrophages and internalize modified lipoproteins to become lipid-laden foam cells.
Ki Hoon Han, Ki Ok Han, Simone R. Green, Oswald Quehenberger   +3 more
doaj   +1 more source