Results 61 to 70 of about 37,429 (252)

Role of MCP-1 and CCR2 in alcohol neurotoxicity [PDF]

Pharmacological Research, 2019
Alcohol abuse causes profound damage to both the developing brain and the adult brain. Prenatal exposure to alcohol results in a wide range of deficits known as fetal alcohol spectrum disorders (FASD). Alcohol abuse in adults is associated with brain shrinkage, memory and attention deficits, communication disorders and physical disabilities.
Kai, Zhang, Jia, Luo
openaire   +2 more sources

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells. [PDF]

PLoS ONE, 2017
Acute myeloid leukemia (AML) has a high mortality rate despite chemotherapy and transplantation. Both CXCR4/SDF-1 and VLA-4/VCAM1 axes are involved in leukemia protection but little is known about the role of CCL2/CCR2 in AML biology and protection ...
Patricia Macanas-Pirard, Thomas Quezada, Leonardo Navarrete, Richard Broekhuizen, Andrea Leisewitz, Bruno Nervi, Pablo A Ramírez   +6 more
doaj   +1 more source

Surface N-Glycosylation Dictates MSC-EV Uptake and CCR2-Driven Monocyte Recruitment to Inflamed Endothelium Under Shear Flow. [PDF]

J Extracell Vesicles
ABSTRACT Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EV) hold promising potential for immunomodulation and tissue regeneration, especially for treating ischemia‐reperfusion injury (IRI). However, their therapeutic use is hindered by challenges in tissue targeting and incomplete understanding of their functional mechanisms.
Clos-Sansalvador M, Monguió-Tortajada M, Garcia SG, Pérez-Martínez M, Sanroque-Muñoz M, Font-Morón M, Megías D, Peset I, Franquesa M, Hergueta-Redondo M, Peinado H, Borràs FE.   +11 more
europepmc   +2 more sources

Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent [PDF]

The American Journal of Pathology, 2014
Development of novel strategies to treat noninfectious posterior uveitis is an ongoing challenge, in part because of limited availability of animal models that mimic the naturally occurring disease in humans. Mice deficient in the autoimmune regulatory gene Aire develop a spontaneous T-cell and macrophage-mediated autoimmune uveitis that closely ...
Chen, YuTing Feeling, Zhou, Delu, Metzger, Todd, Gallup, Marianne, Jeanne, Marion, Gould, Douglas B, Anderson, Mark S, McNamara, Nancy A   +7 more
openaire   +3 more sources

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Ovarian hormones and high-fat diet duration distinctively modulate hypothalamic chemokine profile. [PDF]

J Neuroendocrinol
Abstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Augusto AGB, Dos Santos GA, Cavalheiro IVS, Mantovan VS, Bergantini LS, Marin NP, Dos Santos Alves E, Velloso LA, Mendes NF.   +8 more
europepmc   +2 more sources

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltrationResearch in context

EBioMedicine
Summary: Background: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition.
Hasan Farooq, Hannah P. Luehmann, Jeffrey R. Koenitzer, Gyu Seong Heo, Deborah H. Sultan, Devesha H. Kulkarni, Sean P. Gunsten, Rekha M. Sashti, Tao Huang, Amanda R. Keller, Kory J. Lavine, Jeffrey J. Atkinson, Laura M. Wingler, Yongjian Liu, Steven L. Brody   +14 more
doaj   +1 more source