Results 1 to 10 of about 54,562 (253)

CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab

Frontiers in Immunology, 2021
CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major HIV entry co-receptor, where its surface density correlates with HIV plasma ...
Helen L Wu, Gabriela M Webb, Jason S Reed   +2 more
exaly   +3 more sources

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

Virology, 2010
R5X4 HIV-1 has impaired utilization of CCR5 on primary CD4+ lymphocytes but the mechanisms responsible are not well defined. Using a panel of diverse R5X4 Envs we identified a spectrum of CCR5 use on CD4+ lymphocytes. Greater lymphocyte CCR5 use correlated with relative resistance to CCR5 mAbs and small molecule antagonists.
Loftin, Lamorris M., Kienzle, Martha F., Yi, Yanjie, Lee, Benhur, Lee, Fang-Hua, Gray, Lachlan, Gorry, Paul R., Collman, Ronald G.   +7 more
openaire   +3 more sources

CCR5 and HIV Infection

Receptors and Channels, 2002
Chemokines and chemokine receptors play a crucial role in the trafficking of leukocyte populations across the body, and are involved in the development of a large variety of human diseases. CCR5 is the main coreceptor used by macrophage (M)-tropic strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2, which are responsible for viral ...
Blanpain, Cédric, Libert, Frédérick, Vassart, Gilbert, Parmentier, Marc   +3 more
openaire   +4 more sources

People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells

Scientific Reports, 2022
CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune cells between people living with HIV (PLHIV) using combination antiretroviral therapy (cART) and HIV-uninfected controls, (2) relate CCR5 expression to viral reservoir ...
Louise E. van Eekeren, Vasiliki Matzaraki, Zhenhua Zhang, Lisa van de Wijer, Marc J. T. Blaauw, Marien I. de Jonge, Linos Vandekerckhove, Wim Trypsteen, Leo A. B. Joosten, Mihai G. Netea, Quirijn de Mast, Hans J. P. M. Koenen, Yang Li, André J. A. M. van der Ven   +13 more
doaj   +2 more sources

The frequency of CCR5 promoter polymorphisms and CCR5 Δ 32 mutation in Iranian populations.

Iranian journal of basic medical sciences, 2015
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered
Zare-Bidaki, Mohammad, Karimi-Googheri, Masoud, Hassanshahi, Gholamhossein, Zainodini, Nahid, Kazemi Arababadi, Mohammad   +4 more
openaire   +5 more sources

Genetic and Epigenetic Regulation of CCR5 Transcription [PDF]

Biology, 2012
The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia. Because of this, there is an increasing recognition of the important role of CCR5 in the pathology of (neuro-) inflammatory diseases such as atherosclerosis and multiple ...
Wierda, R.J., van den Elsen, P.J.
openaire   +5 more sources

The role of CCR5 chemokine ligands and antibodies to CCR5 coreceptors in preventing HIV infection

Trends in Immunology, 2002
Abstract HIV infection is transmitted predominantly through mucosal tissues that favour strains of HIV-1 that use CCR5. A lack of cell-surface expression of CCR5 found in the homozygous Δ32 CCR5 mutation, upregulation of CC chemokines and antibodies to CCR5 are associated with resistance to HIV infection.
Lehner, T, Thomas Lehner
openaire   +4 more sources

The frequency of CCR5 promoter polymorphisms and CCR5 32 mutation in Iranian populations [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC  chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5.
Mohammad Zare-Bidaki, Masoud Karimi-Googheri, Gholamhossein Hassanshahi, Nahid Zainodini, Mohammad Kazemi Arababadi   +4 more
doaj   +1 more source

Interleukin-10 Promoter and the CCR5 Polymorphisms in Iranian Azari Population with Multiple Sclerosis [PDF]

Iranian Journal of Immunology, 2021
Background: Changes in the expression of cytokines as the result of the single nucleotide polymorphisms (SNPs), can affect the incidence of multiple sclerosis (MS).
Mohammad Asgharzadeh, Davoud Sanajou, Hossein Samadi Kafil, Mehdi Farhoudi, Daryoush Savadi Oskouei, Fatemeh Khaki-Khatibi, Fatemeh Ahmadi, Manouchehr Fadaee, Ali Vegari, Vahid Asgharzadeh, Jalil Rashedi, Behroz Mahdavi Poor, Pourya Gholizadeh   +12 more
doaj   +1 more source

Structural and Molecular Interactions of CCR5 Inhibitors with CCR5 [PDF]

Journal of Biological Chemistry, 2006
We have characterized the structural and molecular interactions of CC-chemokine receptor 5 (CCR5) with three CCR5 inhibitors active against R5 human immunodeficiency virus type 1 (HIV-1) including the potent in vitro and in vivo CCR5 inhibitor aplaviroc (AVC).
Kenji, Maeda, Debananda, Das, Hiromi, Ogata-Aoki, Hirotomo, Nakata, Toshikazu, Miyakawa, Yasushi, Tojo, Rachael, Norman, Yoshikazu, Takaoka, Jianping, Ding, Gail F, Arnold, Eddy, Arnold, Hiroaki, Mitsuya   +11 more
openaire   +2 more sources