Results 41 to 50 of about 54,562 (253)
Viruses, 2019 SHIV variants KB9 and 89.6 show differential pathogenesis in primate models with KB9 causing rapid CD4 decline while 89.6 failing to induce disease.
Tugba Mehmetoglu-Gurbuz +2 more
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Amino Acid Knowledgebase of CCR5
, 2021 Amino Acid Matrix tab contains all compiled data for each amino acid of the human CCR5 sequence. Alignment matrix contains the 98 species sequences for CCR5 ortholog alignment.
Jeremy Prokop (8082587)
core +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2023 Jie Chen,1,* Weichang Guo,2,* Hejia Yin,1 Liju Ma,3 Shaoyou Li,4 Huifang Li1 1Department of Diabetes, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Department of Physical Education ...
Chen J, Guo W, Yin H, Ma L, Li S, Li H
doaj
BMC Infectious Diseases, 2020 Background Cysteine-cysteine chemokine receptor 5 is the main HIV co-receptor involved in the virus and cell-to-cell spread. A variant of the CCR5 gene known as CCR5-Δ32 which is a product of 32 base pair deletion in the gene plays critical role in the ...
Ekerette Friday Ekere +3 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Binding of fusion protein FLSC IgG1 to CCR5 is enhanced by CCR5 antagonist Maraviroc [PDF]
Antiviral Research, 2014 The CCR5 chemokine receptor is crucial for human immunodeficiency virus type 1 (HIV-1) infection, acting as the principal coreceptor for HIV-1 entry and transmission and is thus an attractive target for antiviral therapy. Studies have suggested that CCR5 surface density and its conformational changes subsequent to virion engagement are rate limiting ...
Olga Latinovic +5 more
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CCR5 status and metastatic progression in colorectal cancer
OncoImmunology, 2019 Multiple reports have highlighted the importance of the local immunological cellular composition (i.e. the density of effector T cells and macrophage polarization state) in predicting clinical outcome in advanced metastatic stage of colorectal cancer ...
Meggy Suarez-Carmona +22 more
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Brain and Behavior, 2023 Background C‐C chemokine receptor 5 (CCR5) is a major coreceptor for Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) cell entry; however, its role in brain pathogenesis is largely understudied.
Julian B. Hattler +3 more
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Advanced Science, EarlyView.Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao +12 more
wiley +1 more source
Structural Basis for the Interaction of CCR5 with a Small Molecule, Functionally Selective CCR5 Agonist [PDF]
The Journal of Immunology, 2006 Abstract The chemokine receptor CCR5 is an attractive target for HIV-1 drug development, as individuals whose cells lack surface CCR5 expression are highly resistant to HIV-1 infection. CCR5 ligands, such as CCL5/RANTES, effectively inhibit HIV-1 infection by competing for binding opportunities to the CCR5 and inducing its ...
Yuji, Saita +8 more
openaire +2 more sources