Results 1 to 10 of about 59,717 (249)
The regulatory network of the chemokine CCL5 in colorectal cancer
Annals of Medicine, 2023 The chemokine CCL5 plays a potential role in the occurrence and development of colorectal cancer (CRC). Previous studies have shown that CCL5 directly acts on tumor cells to change tumor metastatic rates.
Xin-Feng Zhang
exaly +4 more sources
CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome [PDF]
Frontiers in Immunology, 2022 IntroductionIncreased CCL5 expression and CD8 T cells have been shown to be pivotal regulators of immunopathology in primary Sjögren’s syndrome (pSS) and pSS-like disease. Increased CCL5 expression by CCR9+ CD4 T cells has previously been implicated as a
Anneline C. Hinrichs +8 more
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CCL5 improves radiation resistance through activation of the AMPK/mTOR pathway in adenoid cystic carcinoma [PDF]
Journal of Translational MedicineBackground Head and neck adenoid cystic carcinoma (HNACC) is an uncommon but aggressive salivary gland malignancy with high recurrence and metastasis rates.
Mingyu Tan +4 more
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CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells [PDF]
Open Biology, 2016 In earlier studies, we showed that CCL5 enhances proliferation and survival of MCF-7 breast cancer cells in an mTOR-dependent manner and we provided evidence that, for T cells, CCL5 activation of CCR5 results in increased glycolysis and enhanced ATP ...
Darrin Gao +2 more
doaj +1 more source
Медицинская иммунология, 2023 Currently, no drugs have been identified that could slow progression of chronic obstructive pulmonary disease (COPD), or have a significant impact on patient mortality.
A. G. Kadushkin +4 more
doaj +1 more source
Anti-inflammatory Activity of the Protein Z-Dependent Protease Inhibitor
TH Open, 2021 The protein Z (PZ)-dependent plasma protease inhibitor (ZPI) is a glycoprotein that inhibits factor XIa and, in the presence of PZ, FXa. Recently, ZPI has been shown to be an acute-phase protein (APP).
Mahita Razanakolona +10 more
doaj +1 more source
OncoImmunology, 2022 Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Etienne S. Melese +21 more
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mBio, 2021 Zika virus (ZIKV) is a neurovirulent flavivirus that uniquely causes fetal microcephaly, is sexually transmitted, and persists in patients for up to 6 months.
Megan C. Mladinich +4 more
doaj +1 more source
Firing up the cold tumors by targeting Vps34
OncoImmunology, 2020 Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji +4 more
doaj +1 more source
Intrahepatic Expression of C-C Motif ligand 5 in Patients with Chronic Hepatitis B
The Turkish Journal of Gastroenterology, 2021 Background/Aims: C-C motif ligand 5 (CCL5) is reported to play a key role in acute and chronic liver diseases. However, the association between the CCL5 and chronic hepatitis B (CHB) remains to be explored.
Xiang-An Zhao +7 more
doaj +1 more source