Results 41 to 50 of about 50,982 (245)

CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. [PDF]

PLoS ONE, 2012
BACKGROUND: Osteosarcoma is characterized by a high malignant and metastatic potential. CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human cancer ...
Shih-Wei Wang, Hsing-Hsien Wu, Shih-Chia Liu, Po-Chuan Wang, Wen-Chieh Ou, Wen-Yi Chou, Yung-Shuen Shen, Chih-Hsin Tang   +7 more
doaj   +1 more source

The effect of down-regulation of CCL5 on lipopolysaccharide-induced WI-38 fibroblast injury: a potential role for infantile pneumonia [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and
Dong Bai, Anbang Han, Shan Cong
doaj   +1 more source

Interfering with CCL5/CCR5 at the Tumor-Stroma Interface [PDF]

Cancer Cell, 2016
In this issue of Cancer Cell, Halama et al. (2016) further advance chemokine interference as a therapeutic option for cancer by demonstrating the effect of CCR5 blockade in reshaping macrophage polarization toward an anti-tumor functional state in patient-derived tumor models and liver metastases of colorectal cancer patients.
Bronte, Vincenzo, Bria, Emilio
openaire   +4 more sources

CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation.

The Journal of biological chemistry, 2006
CCL5 (RANTES (regulated on activation normal T cell expressed and secreted)) and its cognate receptor, CCR5, have been implicated in T cell activation. CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal. In two CCR5-expressing human T cell
Thomas T, Murooka, Mark M, Wong, Ramtin, Rahbar, Beata, Majchrzak-Kita, Amanda E I, Proudfoot, Eleanor N, Fish   +5 more
openaire   +2 more sources

Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell–Mediated Hepatitis via Compensatory Up-regulation of CXCR2–Related Chemokine ActivitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Chemokine-mediated immune cell recruitment plays pivotal roles in liver inflammation. C-C motif chemokine ligand 5 (CCL5) has been shown to be responsible for the recruitment of monocytes/macrophages and has been implicated in various ...
Lili Chen, Jinyang Gu, Yihan Qian, Meng Li, Yongbing Qian, Min Xu, Jichang Li, Yankai Wen, Lei Xia, Jiaxin Li, Qiang Xia, Xiaoni Kong, Hailong Wu   +12 more
doaj   +1 more source

Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme [PDF]

Radiology and Oncology, 2019
Abstract Background Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12 to 15 months after the diagnosis. This is mostly due to therapy resistant glioblastoma stem cells in addition to intertumour heterogeneity that is due to infiltration of a ...
Koprivnikar Krajnc, Miha, Novak, Metka, Pestell, Richard G., Lah Turnšek, Tamara   +3 more
openaire   +6 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

CCL5 enhances invasion of squamous cell carcinoma via syndecan-1-dependent ERK signaling

Cell Structure and Function
Cancer cells form clusters and invade the surrounding stroma. This phenomenon is associated with metastasis and poor prognosis in patients with cancer. Therefore, prevention of invasion may improve cancer therapy.
Toko Yamazaki, Yuji Kumagai, Kosuke Maeda, Tomoyasu Aizawa, Kosuke Maekawa, Atsushi Enomoto, Seiichiro Ishihara, Hisashi Haga   +7 more
doaj   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer

Clinical and Experimental Gastroenterology, 2020
Tatsuya Yoshida,1 Takuya Miura,1 Tomoh Matsumiya,2 Hidemi Yoshida,2 Hajime Morohashi,1 Yoshiyuki Sakamoto,1 Akira Kurose,3 Tadaatsu Imaizumi,2 Kenichi Hakamada1 1Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine ...
Yoshida T, Miura T, Matsumiya T, Yoshida H, Morohashi H, Sakamoto Y, Kurose A, Imaizumi T, Hakamada K   +8 more
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