Results 21 to 30 of about 50,982 (245)

CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

Frontiers in Immunology, 2022
IntroductionIncreased CCL5 expression and CD8 T cells have been shown to be pivotal regulators of immunopathology in primary Sjögren’s syndrome (pSS) and pSS-like disease. Increased CCL5 expression by CCR9+ CD4 T cells has previously been implicated as a
Anneline C. Hinrichs, Anneline C. Hinrichs, Sofie L. M. Blokland, Sofie L. M. Blokland, Aike A. Kruize, Floris P. J. Lafeber, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +8 more
doaj   +1 more source

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

mBio, 2021
Zika virus (ZIKV) is a neurovirulent flavivirus that uniquely causes fetal microcephaly, is sexually transmitted, and persists in patients for up to 6 months.
Megan C. Mladinich, Jonas N. Conde, William R. Schutt, Sook-Young Sohn, Erich R. Mackow   +4 more
doaj   +1 more source

Firing up the cold tumors by targeting Vps34

OncoImmunology, 2020
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman   +4 more
doaj   +1 more source

CCL5 Modulates Pneumococcal Immunity and Carriage [PDF]

The Journal of Immunology, 2006
Abstract Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious ...
Ravichandran, Palaniappan, Shailesh, Singh, Udai P, Singh, Rajesh, Singh, Edwin W, Ades, David E, Briles, Susan K, Hollingshead, Walter, Royal, Jacquelyn S, Sampson, Jonathan K, Stiles, Dennis D, Taub, James W, Lillard   +11 more
openaire   +2 more sources

Intrahepatic Expression of C-C Motif ligand 5 in Patients with Chronic Hepatitis B

The Turkish Journal of Gastroenterology, 2021
Background/Aims: C-C motif ligand 5 (CCL5) is reported to play a key role in acute and chronic liver diseases. However, the association between the CCL5 and chronic hepatitis B (CHB) remains to be explored.
Xiang-An Zhao, Jian Wang, Haiyan Chang, Yong Liu, Yuxin Chen, Guangmei Chen, Rui Huang, Chao Wu   +7 more
doaj   +1 more source

High-Intensity Interval Training and Vitamin D3 Supplementation Decrease CCL-5 and CCR5 Expression In White Adipose Tissue of Diabetic Rats Fed with A High-Fat Diet and Streptozotocin [PDF]

Cell Journal
Objective: The purpose of this study was to investigate the effects of 8 weeks of high-intensity interval training (HIIT)and vitamin D3 supplementation on Chemokine (C-C motif) Ligand 5 (CCL-5) and C-C motif chemokine receptor 5(CCR5) in the white ...
Fariba Fallahi, Worya Tahmasebi, Mohammad Rahman Rahimi, Mohammad Azizi   +3 more
doaj   +1 more source

Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells

Frontiers in Immunology, 2018
Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can
Sara Scutera, Valentina Salvi, Luisa Lorenzi, Giorgia Piersigilli, Silvia Lonardi, Daniela Alotto, Stefania Casarin, Carlotta Castagnoli, Erica Dander, Giovanna D’Amico, Silvano Sozzani, Tiziana Musso   +11 more
doaj   +1 more source

Role of CCL5 (RANTES) in Viral Lung Disease [PDF]

Journal of Virology, 2006
ABSTRACTCCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics. To examine the role of CCL5 in viral lung disease, we measured its production during primary respiratory syncytial virus (RSV) infection and during secondary infection after sensitizing vaccination that
Culley, Fiona J., Pennycook, Alasdair M J, Tregoning, John S., Dodd, Jonathan S., Walzl, Gerhard, Wells, Timothy N., Hussell, Tracy; id_orcid 0000-0001-7186-6141, Openshaw, Peter J M   +7 more
openaire   +2 more sources

Spinal NF-κB and chemokine ligand 5 expression during spinal glial cell activation in a neuropathic pain model. [PDF]

PLoS ONE, 2015
BACKGROUND:The NF-κB pathway and chemokine (C-C motif) ligand 5 (CCL5) are involved in pain modulation; however, the precise mechanisms of their interactions in chronic neuropathic pain have yet to be established.
Qin Yin, Qin Fan, Yu Zhao, Ming-Yue Cheng, He Liu, Jing Li, Fei-Fei Lu, Jin-Tai Jia, Wei Cheng, Chang-Dong Yan   +9 more
doaj   +1 more source

Metabolic effects of CCL5 deficiency in lean and obese mice

Frontiers in Immunology, 2023
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of immunocytes in adipose tissue during obesity. Chemokine (C-C motif) ligand 5
Hui Zhou, Hui Zhou, Xiyan Liao, Xiyan Liao, Qin Zeng, Qin Zeng, Haowei Zhang, Haowei Zhang, Jianfeng Song, Jianfeng Song, Wanyu Hu, Wanyu Hu, Xiaoxiao Sun, Xiaoxiao Sun, Yujin Ding, Yujin Ding, Dandan Wang, Dandan Wang, Yalun Xiao, Yalun Xiao, Tuo Deng, Tuo Deng, Tuo Deng   +22 more
doaj   +1 more source