Results 21 to 30 of about 59,717 (249)

Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice. [PDF]

Adv Sci (Weinh)
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Yao L, Hatami M, Koc S, Jiang Q, Skutella T, Zhang Y.   +5 more
europepmc   +2 more sources

High-Intensity Interval Training and Vitamin D3 Supplementation Decrease CCL-5 and CCR5 Expression In White Adipose Tissue of Diabetic Rats Fed with A High-Fat Diet and Streptozotocin [PDF]

Cell Journal
Objective: The purpose of this study was to investigate the effects of 8 weeks of high-intensity interval training (HIIT)and vitamin D3 supplementation on Chemokine (C-C motif) Ligand 5 (CCL-5) and C-C motif chemokine receptor 5(CCR5) in the white ...
Fariba Fallahi, Worya Tahmasebi, Mohammad Rahman Rahimi, Mohammad Azizi   +3 more
doaj   +1 more source

Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes [PDF]

, 2012
Cytokines play an important role in ischemic injury and repair. However, little is known about their prognostic value in cardiovascular disease. The aim of this study was to investigate the prognostic importance of chemokines CCL3/MIP-1α, CCL5/RANTES and
van Dieijen-Visser, Marja P., Brenda W. C. Bongaerts (134222), Erik A. L. Biessen (132311), Michael Weber (134225), Brenda W C Bongaerts, Stefanie Dimmeler (134234), van Berkel, Theo J. C., Patty J. Nelemans (134239), Michael Weber, Mat Rousch (134231), Kitty B. J. M. Cleutjens (134238), Jager, Saskia C. A. de, Dieijen-Visser, Marja P. van, Cleutjens, Kitty B. J. M., Nelemans, Patty J., Biessen, Erik A. L., Mat Rousch, Bongaerts, Brenda W. C., Saskia C A de Jager, Marja P. van Dieijen-Visser (134236), Weber, Michael, Marja P van Dieijen-Visser, Adriaan O. Kraaijeveld (134229), Berkel, Theo J. C. van, Rousch, Mat, Biessen, Erik A. L.; id_orcid, de Jager, Saskia C. A., Theo J C van Berkel, Adriaan O Kraaijeveld, Stefanie Dimmeler, Dimmeler, Stefanie, Kraaijeveld, Adriaan O., Theo J. C. van Berkel (132307), Kitty B J M Cleutjens, Erik A L Biessen, Patty J Nelemans, Saskia C. A. de Jager (134219)   +36 more
core   +1 more source

Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells

Frontiers in Immunology, 2018
Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can
Sara Scutera, Valentina Salvi, Luisa Lorenzi, Giorgia Piersigilli, Silvia Lonardi, Daniela Alotto, Stefania Casarin, Carlotta Castagnoli, Erica Dander, Giovanna D’Amico, Silvano Sozzani, Tiziana Musso   +11 more
doaj   +1 more source

Spinal NF-κB and chemokine ligand 5 expression during spinal glial cell activation in a neuropathic pain model. [PDF]

PLoS ONE, 2015
BACKGROUND:The NF-κB pathway and chemokine (C-C motif) ligand 5 (CCL5) are involved in pain modulation; however, the precise mechanisms of their interactions in chronic neuropathic pain have yet to be established.
Qin Yin, Qin Fan, Yu Zhao, Ming-Yue Cheng, He Liu, Jing Li, Fei-Fei Lu, Jin-Tai Jia, Wei Cheng, Chang-Dong Yan   +9 more
doaj   +1 more source

Metabolic effects of CCL5 deficiency in lean and obese mice

Frontiers in Immunology, 2023
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of immunocytes in adipose tissue during obesity. Chemokine (C-C motif) ligand 5
Hui Zhou, Hui Zhou, Xiyan Liao, Xiyan Liao, Qin Zeng, Qin Zeng, Haowei Zhang, Haowei Zhang, Jianfeng Song, Jianfeng Song, Wanyu Hu, Wanyu Hu, Xiaoxiao Sun, Xiaoxiao Sun, Yujin Ding, Yujin Ding, Dandan Wang, Dandan Wang, Yalun Xiao, Yalun Xiao, Tuo Deng, Tuo Deng, Tuo Deng   +22 more
doaj   +1 more source

CCR5 status and metastatic progression in colorectal cancer

OncoImmunology, 2019
Multiple reports have highlighted the importance of the local immunological cellular composition (i.e. the density of effector T cells and macrophage polarization state) in predicting clinical outcome in advanced metastatic stage of colorectal cancer ...
Meggy Suarez-Carmona, Pornpimol Chaorentong, Jakob Nikolas Kather, Rebecca Rothenheber, Azaz Ahmed, Anna Berthel, Anita Heinzelmann, Rodrigo Moraleda, Nektarios A. Valous, Zeynep Kosaloglu, Rosa Eurich, Jana Wolf, Silke Grauling-Halama, Michael Hundemer, Felix Lasitschka, Fee Klupp, Christoph Kahlert, Alexis Ulrich, Martin Schneider, Christine Falk, Dirk Jäger, Inka Zoernig, Niels Halama   +22 more
doaj   +1 more source

CCL5 might be a prognostic biomarker and associated with immuno-therapeutic efficacy in cancers: A pan-cancer analysis

Heliyon, 2023
Purpose: Chemokine ligand 5 (CCL5), a vital member of the CC chemokine family, plays diverse roles in tumorigenesis, metastasis, and prognosis in various human tumors.
Yanchun Huang, Lijuan Wu, Yong Sun, Jiwen Li, Nan Mao, Yeqing Yang, Ming Zhao, Sichong Ren   +7 more
doaj   +1 more source

Regulation of CCL5 expression in smooth muscle cells following arterial injury. [PDF]

PLoS ONE, 2012
Chemokines play a crucial role in inflammation and in the pathophysiology of atherosclerosis by recruiting inflammatory immune cells to the endothelium. Chemokine CCL5 has been shown to be involved in atherosclerosis progression. However, little is known
Huan Liu, Huan Ning, Hongchao Men, Rong Hou, Mingui Fu, Hailin Zhang, Jianguo Liu   +6 more
doaj   +1 more source

A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. [PDF]

PLoS ONE, 2016
The role of CC chemokine receptor 5 (CCR5) and its ligand CCL5 on the pathogenesis of HIV infection has been well studied but not for HCV infection. Here, we investigated whether CCL5 haplotypes influence HIV and HCV seropositivity among 373 Caucasian ...
Kristi Huik, Radko Avi, Merit Pauskar, Eveli Kallas, Ene-Ly Jõgeda, Tõnis Karki, Kristi Rüütel, Ave Talu, Katri Abel-Ollo, Anneli Uusküla, Andrew Carrillo, Sunil K Ahuja, Weijing He, Irja Lutsar   +13 more
doaj   +1 more source