Results 11 to 20 of about 59,717 (249)

Mechanisms Regulating the Secretion of the Promalignancy Chemokine CCL5 by Breast Tumor Cells: CCL5's 40s Loop and Intracellular Glycosaminoglycans [PDF]

open access: yesNeoplasia: An International Journal for Oncology Research, 2012
The chemokine CCL5 (RANTES) plays active promalignancy roles in breast malignancy. The secretion of CCL5 by breast tumor cells is an important step in its tumor-promoting activities; therefore, inhibition of CCL5 secretion may have antitumorigenic ...
Gali Soria   +7 more
doaj   +2 more sources

CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. [PDF]

open access: yesPLoS ONE, 2012
BACKGROUND: Osteosarcoma is characterized by a high malignant and metastatic potential. CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human cancer ...
Shih-Wei Wang   +7 more
doaj   +2 more sources

CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture [PDF]

open access: yesEuropean Cells & Materials, 2014
Release of chemotactic factors in response to tissue damage has been described for different musculoskeletal tissues, including the intervertebral disc (IVD). This study investigated the chemoattractants that are released by induced degenerative IVDs and
G Pattappa   +6 more
doaj   +4 more sources

CCL5 regulation of mucosal chlamydial immunity and infection

open access: yesBMC Microbiology, 2008
Background Following genital chlamydial infection, an early T helper type 1 (Th1)-associated immune response precedes the activation and recruitment of specific Th1 cells bearing distinct chemokine receptors, subsequently leading to the clearance of ...
Igietseme Joseph U   +5 more
doaj   +2 more sources

Comprehensive analysis of the potential biological significance of CCL5 in pan-cancer prognosis and immunotherapy

open access: yesScientific Reports
C-C chemokine ligand 5 (CCL5) plays a crucial role in the advancement of human cancer. Nevertheless, little is known about the multi-omics characterisation of CCL5 and its significance for the immune microenvironment and prognosis of tumor patients.
Jingjing Shan, Yan Xu, Yu Lun
doaj   +2 more sources

Chronic HBV Infection Disrupts CCL5-Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV-Specific T Cells. [PDF]

open access: yesAdv Sci (Weinh)
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Yang A   +9 more
europepmc   +2 more sources

Development of an Electrochemical CCL5 Chemokine Immunoplatform for Rapid Diagnosis of Multiple Sclerosis [PDF]

open access: yes, 2022
Serum level of CCL5 chemokine is considered an emerging biomarker for multiple sclerosis (MS). Due to the lack of specific assays for this disease, the development of a point-of-care test for rapid detection of MS could lead to avoiding diagnostics ...
Araceli González-Cortés   +17 more
core   +1 more source

CCL5 Levels Predict Stroke Volume Growth in Acute Ischemic Stroke and Significantly Diminish in Hemorrhagic Stroke Patients [PDF]

open access: yes, 2022
Stroke remains an important health challenge. Here, we study whether circulating chemokine (C-C motif) ligand 5 (CCL5) levels may predict clinical outcomes for stroke patients.
Enrique Ramalle-Gómara   +12 more
core   +1 more source

Comparison of our CCR5-CCL5-I and -II systems with the experimental structure (PDB ID: 7O7F), a complex of CCR5 with a modified CCL5 chemokine, the super-agonist [6P4]CCL5.

open access: yes, 2022
(A) The RMSD of the backbone with a defined secondary structure (i.e., helices and beta-sheets) were calculated on our trajectory with respect 7O7F. The predominant decrease in the RMSD of replicate I suggests that our system approximates to the full ...
Laura Dominguez (1326021)   +1 more
core   +1 more source

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies. [PDF]

open access: yes, 2011
The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be
Hilma Holm   +337 more
core   +2 more sources

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