Results 11 to 20 of about 50,982 (245)
The regulatory network of the chemokine CCL5 in colorectal cancer
Annals of Medicine, 2023 The chemokine CCL5 plays a potential role in the occurrence and development of colorectal cancer (CRC). Previous studies have shown that CCL5 directly acts on tumor cells to change tumor metastatic rates.
Xin-Feng Zhang, Hua-You Luo
exaly +5 more sources
CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells [PDF]
Open Biology, 2016 In earlier studies, we showed that CCL5 enhances proliferation and survival of MCF-7 breast cancer cells in an mTOR-dependent manner and we provided evidence that, for T cells, CCL5 activation of CCR5 results in increased glycolysis and enhanced ATP ...
Ramtin Rahbar, Eleanor N Fish
exaly +2 more sources
CCL5 mediates breast cancer metastasis and prognosis through CCR5/Treg cells
Frontiers in Oncology, 2022 Background and aimsCCL5 is considered to contribute to the biological function of a variety of cancer types, but its specific mechanism is still unclear.
Faqing Liang, Qing Lv, Zhenggui Du
exaly +3 more sources
Neoplasia: An International Journal for Oncology Research, 2012 The chemokine CCL5 (RANTES) plays active promalignancy roles in breast malignancy. The secretion of CCL5 by breast tumor cells is an important step in its tumor-promoting activities; therefore, inhibition of CCL5 secretion may have antitumorigenic ...
Gali Soria +7 more
doaj +3 more sources
CCL5 regulation of mucosal chlamydial immunity and infection [PDF]
BMC Microbiology, 2008 Background Following genital chlamydial infection, an early T helper type 1 (Th1)-associated immune response precedes the activation and recruitment of specific Th1 cells bearing distinct chemokine receptors, subsequently leading to the clearance of ...
Igietseme Joseph U +5 more
doaj +3 more sources
Toxoplasma effector GRA15-driven CCL5 secretion enhances brain parasite load through microvascular sequestration of phagocytes [PDF]
mBioToxoplasma gondii exploits host phagocytes to disseminate systemically and establish infection in the central nervous system (CNS). Yet, the mechanisms governing the interaction between parasitized phagocytes and the brain endothelium remain elusive ...
Elena Afanaseva +2 more
doaj +2 more sources
Медицинская иммунология, 2023 Currently, no drugs have been identified that could slow progression of chronic obstructive pulmonary disease (COPD), or have a significant impact on patient mortality.
A. G. Kadushkin +4 more
doaj +1 more source
The Inflammatory Chemokine CCL5 and Cancer Progression [PDF]
Mediators of Inflammation, 2014 Until recently, inflammatory chemokines were viewed mainly as indispensable “gate keepers” of immunity and inflammation. However, updated research indicates that cancer cells subvert the normal chemokine system and these molecules and their receptors become important constituents of the tumor microenvironment with very different ways to exert tumor ...
Donatella Aldinucci, Alfonso Colombatti
openaire +4 more sources
Anti-inflammatory Activity of the Protein Z-Dependent Protease Inhibitor
TH Open, 2021 The protein Z (PZ)-dependent plasma protease inhibitor (ZPI) is a glycoprotein that inhibits factor XIa and, in the presence of PZ, FXa. Recently, ZPI has been shown to be an acute-phase protein (APP).
Mahita Razanakolona +10 more
doaj +1 more source
OncoImmunology, 2022 Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Etienne S. Melese +21 more
doaj +1 more source