Results 61 to 70 of about 54,562 (253)

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism.

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
de Lara, C, Zhang Yan, Hegedus Andrea, Karoliina Laamanen, Derek Macallan, de Lara Catherine, Peter Beverley, Laamanen Karoliina, Catherine de Lara (339229), Karoliina Laamanen (233571), Yan Zhang (8098), Worth Andrew, Laamanen, K, Andrew Worth, Andrea Hegedus, Hegedus, A, Beverley Peter, Andrew Worth (404365), Worth, A, Zhang, Y, Macallan, D, Andrea Hegedus (404366), Peter Beverley (404367), Macallan Derek, Beverley, P, Yan Zhang, Catherine de Lara, Derek Macallan (404368)   +27 more
core   +1 more source

CCR5 receptor occupancy (RO) assays.

, 2022
(A-B) Representative flow cytometric analysis for (A) Eq 1 and (B) Eq 2 used to calculate for CCR5 RO by Leronlimab. (C) Representative flow cytometry plots displaying the different components required to calculate each equation, and at different levels ...
Michael J. Corley (7447133), Alnor M. Carnate (12328679), Jonah B. Sacha (8299293), Ivo Sah Bandar (12328676), Jimmy Le (9501194), Jacob P. Lalezari (12328673), Jeffrey Torgerson (12328664), Rebecca Agnor (12328667), Rachele M. Bochart (10777099), Whitney C. Weber (8566797), Xiao L. Chang (11728946), Joseph Hwang (11728955), Miranda Fischer (339874), Nader Pourhassan (11728973), Jeremy Smedley (243755), Justin M. Greene (8299254), Gabriela M. Webb (8566788), Lina Gao (260424), Helen L. Wu (8566794), Courtney Waytashek (11728958), Oriene Shiel (10777114), Scott G. Hansen (9681992), Benjamin N. Bimber (9681995), Travis Giobbi (12328661), Katherine B. Bateman (8566800), Kush Dhody (12328670), Scott Kelly (7183421), Don Siess (12328658), Lishomwa C. Ndhlovu (7122293), Cleiton Pessoa (11728964), Jason S. Reed (8566803), Hugh Crank (3310332), Alina S. Pang (12328682), Cassandra Moats (12328655)   +33 more
core   +1 more source

A functional interaction between the CCR5 and CD34 molecules expressed in hematopoietic cells can support (or even promote) the development of cancer

Hematology, Transfusion and Cell Therapy, 2020
Inflammation and angiogenesis are linked to the development of cancer since both can support the establishment of a tumor-prone microenvironment. The CCR5 is a major regulatory molecule involved in inflammation. The CD34 molecule is commonly described as
Bruna Kulmann-Leal, Joel Henrique Ellwanger, José Artur Bogo Chies   +2 more
doaj   +1 more source

CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome

Breast Cancer Research, 2022
Background CCR5 is a motility chemokine receptor implicated in tumor progression, whose activation and subsequent endocytosis may identify highly aggressive breast cancer cell subtypes likely to spread into the circulatory system.
Ashvathi Raghavakaimal, Massimo Cristofanilli, Cha-Mei Tang, R. K. Alpaugh, Kirby P. Gardner, Saranya Chumsri, Daniel L. Adams   +6 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue

, 2004
Identification of cellular factors involved in HIV-1 entry and transmission at mucosal surfaces is critical for understanding viral pathogenesis and development of effective prevention strategies. Here we describe the evaluation of HIV-1 entry inhibitors
Ines Frank, Griffin, GE, Griffin, George E., George E. Griffin, Santos, John J., John P. Moore, Robin J. Shattock, Shattock, Robin J., Watts, Patricia, John J. Santos, Patricia Watts, Santos, JJ, Shattock, RJ, Vennansha Williams, Williams, V, Moore, JP, Williams, Vennansha G., Robbiani, Melissa, Hu, Qinxue, Qinxue Hu, Pope, M, Melissa Pope, Moore, John P., Frank, Ines, Hu, Q, Frank, I, Watts, P   +26 more
core   +1 more source

Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. [PDF]

PLoS ONE, 2008
BACKGROUND: Dimerization has emerged as an important feature of chemokine G-protein-coupled receptors. CXCR4 and CCR5 regulate leukocyte chemotaxis and also serve as a co-receptor for HIV entry.
Nilgun Isik, Dale Hereld, Tian Jin
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice

Frontiers in Bioscience-Landmark
Background: As pivotal immunoregulatory sentinels in pulmonary defense systems, alveolar macrophages (AMs) play dual roles in mediating inflammatory responses and tissue repair processes during various phases of inflammatory cascades ...
Ruiyu Zhang, Hui Du, Zhi Liu, Yuxi Lei, Huizhi Hu, Junwen Zheng, Pu Yang, Dongchi Zhao   +7 more
doaj   +1 more source