Results 81 to 90 of about 58,061 (209)

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

CCR5 receptor occupancy (RO) assays.

, 2022
(A-B) Representative flow cytometric analysis for (A) Eq 1 and (B) Eq 2 used to calculate for CCR5 RO by Leronlimab. (C) Representative flow cytometry plots displaying the different components required to calculate each equation, and at different levels ...
Michael J. Corley (7447133), Alnor M. Carnate (12328679), Jonah B. Sacha (8299293), Ivo Sah Bandar (12328676), Jimmy Le (9501194), Jacob P. Lalezari (12328673), Jeffrey Torgerson (12328664), Rebecca Agnor (12328667), Rachele M. Bochart (10777099), Whitney C. Weber (8566797), Xiao L. Chang (11728946), Joseph Hwang (11728955), Miranda Fischer (339874), Nader Pourhassan (11728973), Jeremy Smedley (243755), Justin M. Greene (8299254), Gabriela M. Webb (8566788), Lina Gao (260424), Helen L. Wu (8566794), Courtney Waytashek (11728958), Oriene Shiel (10777114), Scott G. Hansen (9681992), Benjamin N. Bimber (9681995), Travis Giobbi (12328661), Katherine B. Bateman (8566800), Kush Dhody (12328670), Scott Kelly (7183421), Don Siess (12328658), Lishomwa C. Ndhlovu (7122293), Cleiton Pessoa (11728964), Jason S. Reed (8566803), Hugh Crank (3310332), Alina S. Pang (12328682), Cassandra Moats (12328655)   +33 more
core   +1 more source

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

CCR5 gene disruption by RNA-guided Cas9 endonuclease in sorted CCR5-/CR1, CCR5-/CR2 and CCR5-/CR3 cells by Sanger sequencing analysis.

, 2014
A-C. Cell surface expression of CCR5 on sorted CCR5-/CR1 (A), CCR5-/CR2 (B) and CCR5-/CR3 (C) TZM.bl cells as compared to mock-transduced TZM.bl cells. D-F.
Chaobaihui Ye (679490), Jingjing Liu (305549), Weiming Wang (158128), Jason T. Kimata (184030), Paul Zhou (354201), Di Zhang (197959)   +5 more
core   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Analyse par suivi de particule unique à la surface de lymphocytes vivants de l'organisation dynamique des récepteurs CD4 et CCR5 impliqués dans l'infection par le VIH [PDF]

, 2012
L'infection de lymphocytes T CD4+ par le virus de l'immunodéficience humaine (VIH) débute par l'interaction séquentielle de la protéine d'enveloppe du virus gp120 avec le récepteur primaire CD4 puis avec un corécepteur, CCR5 dans la majorité des cas de ...
Mascalchi, Patrice
core  

Surface CCR5 conformation localization within U87.CD4.CCR5-GFP cells.

, 2014
Representative images from (A-D) U87.CD4.CCR5-GFP or (E-H) 293-Affinofile cells stained with the indicated CCR5 MAbs (red). CCR5 MAb 45531 exhibited a more punctate staining pattern than other MAbs.
Thomas J. Hope (108657), Ayanna J. Flegler (529080), Gianguido C. Cianci (150443)   +2 more
core   +1 more source

Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso

Open Life Sciences
Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) (GenBank: NC_000003.12, ID: 1234) genes may increase the risk of developing breast cancer. The aim of this study was to investigate the probable
Traoré Lassina, Savadogo Mousso, Zouré Abdou Azaque, Kiendrebeogo Touwendpoulimdé Isabelle, Soudre Fabienne Marie B. T. B., Dabre Soayebo, Traore Aida Djé Djénéba, Adico Marc Donald Wilfried, Lare Tilate, Ouedraogo Teega-Wendé Clarisse, Ouedraogo Rogomenoma Alice, Ouattara Abdoul Karim, Yelemkoure Edwige T., Sawadogo Alexis Yobi, Zongo Nayi, Bambara Hierrhum Aboubacar, Nadembega Christelle W., Djigma Florencia W., Simpore Jacques   +18 more
doaj   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5

Virus Research
CCR5 is the main co-receptor for HIV-1 cell entry and it plays key roles in HIV-1 mucosal transmission. Natural anti-CCR5 antibodies were found in HIV-1-exposed seronegative and long-term non-progressor subjects, suggesting a role in controlling viral ...
Iole Farina, Mauro Andreotti, Claudia Pastori, Roberta Bona, Clementina Maria Galluzzo, Roberta Amici, Cristina Purificato, Caterina Uberti-Foppa, Agostino Riva, Maria Cristina Gauzzi, Lucia Lopalco, Laura Fantuzzi   +11 more
doaj   +1 more source