Results 91 to 100 of about 54,562 (253)
International Journal of Cancer, EarlyView.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
, 2014 A) Inhibition of CCR5 expression in the CEM.NKR-CCR5 CD4-positive lymphocyte cell line, as indicated by FACS assay of CCR5-positive cells. Experiments were repeated three times.
Kevin Chen (264284) +8 more
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li +3 more
wiley +1 more source
Factores inmunogenéticos relacionados con la resistencia/susceptibilidad a la infección por el VIH-1 y su progresión hacia SIDA [PDF]
, 2006 [spa] Los individuos expuestos al VIH-1 y no infectados y los pacientes infectados no progresores de larga duración son situaciones modelo para estudiar factores del huésped implicados en conferir resistencia a la infección / progresión y su conocimiento
Soriano Viladomiu, Alex
core
TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu +8 more
wiley +1 more source
Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells
, 2008 Background and purpose: The CCR5 chemokine receptor is a member of the G protein-coupled receptor (GPCR) family that is expressed by macrophages, memory T-lymphocytes and dendritic cells and is activated by chemotactic proteins (e.g.
Longden, James, Cooke, E-L, Hill, SJ
core +1 more source
mBio, 2016 Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor type 5 (CCR5), CXCR1, CXCR2, and DARC.
Kayan Tam +8 more
doaj +1 more source
Precision Medical Sciences, EarlyView.Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley +1 more source
C-C Chemokine Receptor 5 and HIV: Therapeutic Potentials of the Δ32 Base Pair Deletion
, 2011 The human immunodeficiency virus, a retrovirus discovered in 1981, has reached pandemic status worldwide. Without an existing cure or vaccine, a majority of the world’s population remains at risk for infection and more than 35 million people to date have
Antczak, Amanda R.
core
DRiP78 interaction with CCR5 homodimers.
, 2013 a) CXCR4 and CCR5 sequences corresponding to the potential interaction site of DRiP78, starting at the beginning of the carboxy-terminal tail of the receptor.
Jennifer Frazer (315636) +6 more
core +1 more source