Results 101 to 110 of about 58,061 (209)
Profile of maraviroc: a CCR5 antagonist in the management of treatment-experienced HIV patients
, 2010 Thore LorenzenIFI Institute for Interdisciplinary Medicine, Hamburg, GermanyAbstract: Maraviroc is the first and, so far, the only licensed representative of the class of chemokine receptor type 5 (CCR5) inhibitors used for the treatment of human ...
Thore Lorenzen
core
DRiP78 interaction with CCR5 homodimers.
, 2013 a) CXCR4 and CCR5 sequences corresponding to the potential interaction site of DRiP78, starting at the beginning of the carboxy-terminal tail of the receptor.
Jennifer Frazer (315636) +6 more
core +1 more source
Retrovirology, 2004 Background CCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents.
De Clercq Erik +4 more
doaj +1 more source
A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance
Cell Proliferation, EarlyView.SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu +11 more
wiley +1 more source
Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells
, 2008 Background and purpose: The CCR5 chemokine receptor is a member of the G protein-coupled receptor (GPCR) family that is expressed by macrophages, memory T-lymphocytes and dendritic cells and is activated by chemotactic proteins (e.g.
Longden, James, Cooke, E-L, Hill, SJ
core +1 more source
, 2018 Over 80 million people have been infected with Human Immunodeficiency Virus 1 (HIV-1) worldwide. Despite advances in the treatment of HIV-1 infected individuals, practical cure or prevention of HIV-1 infections has not been achieved.
Espy, Nicole Joy
core +4 more sources
Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1
The FEBS Journal, EarlyView.Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka +10 more
wiley +1 more source
The role of CCR5 chemokine ligands and antibodies to CCR5 coreceptors in preventing HIV infection
, 2002 HIV infection is transmitted predominantly through mucosal tissues that favour strains of HIV-1 that use CCR5. A lack of cell-surface expression of CCR5 found in the homozygous Delta32 CCR5 mutation, upregulation of CC chemokines and antibodies to CCR5 ...
Lehner, T, Thomas Lehner
core +1 more source
DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER [PDF]
, 2013 The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists.
Arnatt, Christopher Kent
core +1 more source
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source