Results 121 to 130 of about 58,061 (209)

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Consumer Cultural Renaissance: Conceptualisation, Scale Development, and Validation

Psychology &Marketing, Volume 43, Issue 11, Page 3178-3189, November 2026.
ABSTRACT As incessant globalisation leads to the pervasive erosion of traditional Asian culture by Western consumerism, a recent phenomenon has emerged that allures Asian consumers to reconnect with their traditional culture via consumption. We postulate that this behaviour is rooted in a self‐identity, consumer cultural renaissance (CCR), that has not
Richard Lee, Huda Khan, Jianyao Li, Muhammad Rashid Saeed   +3 more
wiley   +1 more source

CCL5 and GLUT1 define leader cells in collective invasion of colorectal cancer

The Journal of Pathology, Volume 270, Issue 3, Page 288-302, November 2026.
Abstract Invasion and metastasis in multiple solid tumors are promoted by collective invasion which is organized by leader and follower cells. Yet in colorectal cancer (CRC), biomarkers and mechanisms that specify leader cells remain undefined. Here we identify biomarkers of leader cells and elucidate how they drive CRC collective invasion and ...
Zhaowen Zhang, Jiaying Tan, Zhicheng Zeng, Xiaohui Zhu, Liyao Mai, Yao Yin, Yuting Huang, Wei Kang, Honghui Jiang, Shaowan Xu, Yanqing Ding, Xinghua Pan, Feifei Wang, Li Liang   +13 more
wiley   +1 more source

CCR5 and HIV infection.

, 2002
Chemokines and chemokine receptors play a crucial role in the trafficking of leukocyte populations across the body, and are involved in the development of a large variety of human diseases.
Libert, Frédérick, Parmentier, Marc, Blanpain, Cédric, Vassart, Gilbert   +3 more
core   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, Volume 100, Issue 4, Page 824-840, October 2026.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Comparative Docking Study of Anibamine as the First Natural Product CCR5 Antagonist in CCR5 Homology Models

, 2016
Anibamine, a novel pyridine quaternary alkaloid recently isolated from Aniba sp., has been found to effectively bind to the chemokine receptor CCR5 with an IC50 at 1 μM in competition with 125I-gp120, an HIV viral envelope protein binding to CCR5 with ...
Glen E. Kellogg (204170), Guo Li (174860), Yan Zhang (8098), Kendra M. Haney (2162569)   +3 more
core   +1 more source

Synergistic Cytotoxicity of Cafestol and Kahweol With Doxorubicin in Breast Cancer Cells Involves TNF‑α Targeting and NF‑κB Downregulation

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
Cafestol and kahweol (C&K) are cytotoxic to breast cancer cells and have a synergistic effect with doxorubicin. C&K interact with TNF‐α and downregulate the TNF‐α/NF‐κB pathway, underscoring their therapeutic potential for breast cancer. NIAID Visual & Medical Arts. Generic Cells. NIAID NIH BIOART Source. bioart.niaid.nih.gov/bioart/171. NIAID Visual &
Layane D. Souza, Fábio Junior M. Novaes, Carlos Luan A. Passos, Ísis S. S. de Amorim, Pedro Nicolau‐Neto, Juliana A. Rodrigues, Adilson F. Teixeira, Christian Ferreira, Nathalia Alexia N. dos Santos, Priscila G. Camargo, Marcelle L. F. Bispo, Camilo Henrique S. Lima, Bruno Ricardo B. Pires, Adenilson de Sousa da Fonseca, Claudia M. Rezende, Eliane Fialho, Andre Luiz Mencalha   +16 more
wiley   +1 more source

Beyond the Heart‐Lung Axis: A Review of the Crosstalk Between the Hemodynamic, Neurohormonal, and Immune Systems in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Pulmonary hypertension is driven by dynamic crosstalk beyond the physical connection between the heart and lung, involving neurohormonal systems, immune pathways, and peripheral organs. This review highlights how multisystem signaling contributes to disease progression and may reveal new diagnostic and therapeutic targets.
Alejandro A. Vega, Juliet M. Alfaro, David S. Pinto, Maryam Emamimeybodi, Soban Umar   +4 more
wiley   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source