Results 121 to 130 of about 54,562 (253)

Analyse par suivi de particule unique à la surface de lymphocytes vivants de l'organisation dynamique des récepteurs CD4 et CCR5 impliqués dans l'infection par le VIH

, 2012
L'infection de lymphocytes T CD4+ par le virus de l'immunodéficience humaine (VIH) débute par l'interaction séquentielle de la protéine d'enveloppe du virus gp120 avec le récepteur primaire CD4 puis avec un corécepteur, CCR5 dans la majorité des cas de ...
Mascalchi, Patrice
core  

Comparative Docking Study of Anibamine as the First Natural Product CCR5 Antagonist in CCR5 Homology Models

, 2016
Anibamine, a novel pyridine quaternary alkaloid recently isolated from Aniba sp., has been found to effectively bind to the chemokine receptor CCR5 with an IC50 at 1 μM in competition with 125I-gp120, an HIV viral envelope protein binding to CCR5 with ...
Glen E. Kellogg (204170), Guo Li (174860), Yan Zhang (8098), Kendra M. Haney (2162569)   +3 more
core   +1 more source

Lack of CCR5 modifies glial phenotypes and population of the nigral dopaminergic neurons, but not MPTP-induced dopaminergic neurodegeneration

Neurobiology of Disease, 2013
Constitutive expression of C–C chemokine receptor (CCR) 5 has been detected in astrocytes, microglia and neurons, but its physiological roles in the central nervous system are obscure. The bidirectional interactions between neuron and glial cells through
Dong-Young Choi, Myung Koo Lee, Jin Tae Hong   +2 more
doaj   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

CCR5: Window of Biocapitalism [PDF]

Cell, 2015
The author of the Genealogy of a Gene, Myles W. Jackson, uses the gene CCR5 as a window framing a vista of biocapitalism. With many compartmentalized panes, this window looks at different edges of its scene as the author retells the scientific and pharmaceutical history of CCR5, discusses the world of intellectual property, and ends with thought ...
openaire   +1 more source

CCR5 polymorphisms and haplotypes.

, 2013
On the basis of the linkage disequilibrium patterns between the polymorphisms in the coding (Δ32) and noncoding (promoter) region of CCR5 and the coding polymorphism (V64I) in CCR2, we previously used an evolutionary-based strategy to generate the CCR5 ...
Tõnis Karki (437679), Merit Pauskar (437677), Weijing He (118081), Katri Abel-Ollo (437685), Ave Talu (437684), Maarja Sadam (437678), Tõnu Krispin (437680), Anneli Uusküla (437686), Kristi Huik (437673), Ulvi-Kaire Kongo (437681), Kristi Rüütel (437683), Sunil K. Ahuja (220342), Radko Avi (437674), Andrew Carrillo (437675), Nathan Harper (437676), Irja Lutsar (437687), Tatiana Jermilova (437682)   +16 more
core   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Peri‐Implantitis and Periodontitis: Biological Convergence, Contextual Divergence

Journal of Periodontal Research, EarlyView.
Periodontal and peri‐implant tissues differ and coincide in many aspects, from the clinical and radiological perspective, including histology, microbiology, and molecular markers. Thus, health and disease may also follow different and similar routes.
Pablo Galindo‐Moreno, Pablo Galindo‐Fernandez, Allinson Olaechea, Francisco O'Valle, Abdusalam E. Alrmali, Hom‐Lay Wang, Miguel Padial‐Molina   +6 more
wiley   +1 more source

Monocyte Chemotactic Factors in the Airways of Patients With Mild Asthma Before and After an Allergen Challenge

Allergy, EarlyView.
Nami Shrestha Palikhe, Yingqi Wu, Karen J. Howie, Caitlin Stevens, Jennifer Mitchell, Lesley Wiltshire, Gail M. Gauvreau, Harissios Vliagoftis   +7 more
wiley   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source