Results 131 to 140 of about 58,061 (209)

CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions.

PLoS Pathogens
Cytolytic CD8+ T cells mediate immunopathology in cutaneous leishmaniasis without controlling parasites. Here, we identify factors involved in CD8+ T cell migration to the lesion that could be targeted to ameliorate disease severity.
Laís Amorim Sacramento, Camila Farias Amorim, Claudia G Lombana, Daniel Beiting, Fernanda Novais, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott   +7 more
doaj   +1 more source

Stability‐guided transition modelling reveals an Active‐to‐Evasive immune ecosystem continuum in cervical cancer

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
A stability‐guided, transition‐aware systems immuno‐oncology framework reveals an Active‐to‐Evasive immune ecosystem continuum in TCGA‐CESC. The biologically structured Intermediate region and complementary robustness analyses support graded immune attenuation, adaptive ecosystem remodelling, and increasing immune–tumour uncoupling across this cross ...
Chia‐Hung Chen, Tzu‐Hsiang Weng, Hui‐Ju Kao, Chen‐Lin Yu, Cheng‐Yi Pan, Chen‐Chen Huang, Kai‐Yao Huang, Shun‐Long Weng   +7 more
wiley   +1 more source

Caracterização do envolvimento de quimiocinas nas alterações moleculares e comportamentais induzidas pelo peptídeo beta-amilóide (1-40) em camundongos [PDF]

, 2009
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaEstudos recentes sugerem que o acúmulo de células gliais ativadas em áreas cerebrais importantes no controle cognitivo ...
Passos, Giselle Fazzioni
core  

Cell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

Glia, Volume 74, Issue 10, October 2026.
Cell type–specific EVs were isolated from mouse brain and profiled by proteomics. Each EV subtype exhibited proteomic signatures consistent with the specialized functions of its cell of origin. Astrocyte‐derived EVs (ADEVs) were enriched for the GlialCAM/MLC1 network and GPCRs.
Alba M. Lucart‐Sanchez, Edward Sellés‐Climent, Jorge Navarro‐Calvo, Guillem Pont‐Espinós, Jose A. Gomez‐Sanchez, Raúl Estévez, Luis M. Valor, Rocío Pérez‐González   +7 more
wiley   +1 more source

Enrichment and Proteomic Profiling of Stromal‐Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size‐Exclusion Chromatography Coupled to CD90‐Directed Immunocapture

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Synovial fluid contains heterogeneous EV populations reflecting stromal and immune‐associated cellular inputs from the arthritic joint. SEC‐UF enrichment coupled to CD90‐targeted immunocapture enables recovery of stromal‐associated EV subpopulation from complex patient synovial fluid, while focused LC‐MS/MS and cell‐of‐origin analysis enable molecular ...
Stefanie Kurth, Edveena Hanser, Simone Häner‐Massimi, Stavros Giaglis, Florian Geier, Dominik Burri, Katarzyna Buczak, Ute Heider, Stefan Wild, Yves P. Acklin, Christian Egloff, André N. Tiaden, Diego Kyburz   +12 more
wiley   +1 more source

Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells

Scientific Reports
For the entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells, CCR5 functions as a coreceptor following the binding of the envelope glycoprotein gp120 to the receptor CD4.
Joyce Appiah-Kubi, Yuan Yuzhe, Takeo Kuwata, Hiromi Terasawa, Perpetual Nyame, Wright Ofotsu Amesimeku, Md. Jakir Hossain, Shuzo Matsushita, Tomohiro Sawa, Yosuke Maeda, Shinji Harada, Keisuke Yusa, Kazuaki Monde   +12 more
doaj   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
wiley   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

Small, Volume 22, Issue 55, 1 October 2026.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim, Lingqing Zong, Wei Deng, Maria Kavallaris, Zi Gu   +4 more
wiley   +1 more source