Results 141 to 150 of about 54,562 (253)

CC Chemokine Receptor 5 (CCR5) Desensitization

, 2010
CC chemokine receptor 5 (CCR5), the major HIV coreceptor, is a G protein-coupled receptor (GPCR) involved in cell activation and migration in response to chemokines.
Michelangelo Foti, Gaertner, Hubert François, Hartley, Oliver, Foti, Michelangelo, Oliver Hartley, Hubert Gaertner, Escola, Jean-Michel, Kuenzi, Gabriel, Gabriel Kuenzi, Jean-Michel Escola   +9 more
core   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

Phenotypic Expressions of CCR5-Δ32/Δ32 Homozygosity

, 1999
Objective: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-Δ32/Δ32 homozygous genotype has phenotypic expressions other than those related to HIV-1.
Konkle, Barbara, Cindy Leissinger, Michael Dean, Naomi Luban, Eyster, M. Elaine, Judith A. Beeler, Donna DiMichele, Nguyen, Giang T., M. Elaine Eyster, DiMichele, Donna, O\u27Brien, Stephen J., Alan R. Cohen, Kessler, Craig M., Leissinger, Cindy, Blatt, Philip M., Dean, Michael, Louis M. Aledort, Beeler, Judith A., James J. Goedert, Thomas R. O'Brien, Aledort, Louis M., Cohen, Alan R., Craig M. Kessler, Stephen J. O'Brien, Luban, Naomi, Giang T. Nguyêñ, Carrington, Mary, Barbara Konkle, Goedert, James J., Philip M. Blatt, Mary Carrington, O\u27Brien, Thomas R.   +31 more
core   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Distribution of CCR5 genotype of included studies.

, 2013
1CCR5 homozygotes.2CCR5-Δ32 heterozygotes.
Hao Ying (123117), HuanZhang Zhu (5649772), ChuiJin Kong (327329), Jie Wu (10038), SiJie Liu (5649769)   +4 more
core   +1 more source

Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang, Sean P. Giblin, James E. Pease   +2 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

Análise de possíveis fatores relacionados à resistência ao HIV em parceiros soronegativos de casais HIV-sorodiscordantes da região da Grande Florianópolis [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2014.Atualmente, existem diversos relatos de indivíduos que se expuseram ao HIV e não
Santos, Iris Mattos
core  

Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors

, 2011
Resistance to small-molecule CCR5 inhibitors arises when HIV-1 variants acquire the ability to use inhibitor-bound CCR5 while still recognizing free CCR5. Two isolates, CC101.19 and D1/85.16, became resistant via four substitutions in the gp120 V3 region
Nagashima, Kirsten A., Hope, Thomas J., Sanders, Rogier W., John P. Moore, Danny Lascano, Kirsten A. Nagashima, Thomas J. Hope, Sakmar, Thomas P., Per Johan Klasse, Moore, John P., Klasse, Per Johan, Reem Berro, Rogier W. Sanders, Lascano, Danny, Berro, Reem, Flegler, Ayanna, Ayanna Flegler, Thomas P. Sakmar   +17 more
core   +1 more source

Renal allograft rejection in chemokine receptor Ccr1-/-, Ccr5-/- and Ccr1-/-/Ccr5-/- mice and impact of Ccr5 deficiency on macrophage polarization

, 2009
Previous studies showed that loss of the chemokine receptor Ccr1 or Ccr5 has a beneficial effect on survival of cardiac, carotid, corneal and islet allografts in mice. Additionally, human renal allograft recipients homozygous for a null allele of CCR5 (CCR5delta32) experience significantly prolonged allograft survival.
openaire   +2 more sources