Expression, purification and characterization of the HIV-1 coreceptor CCR5 and its ligand RANTES and high-pressure NMR investigation of hydrogen bonds in biomolecules [PDF]
, 2010 Nuclear magnetic resonance spectroscopy is a very versatile technique for the investigation of biomolecular structures and dynamics. In this thesis, solution and solid state NMR methods have been applied to study a membrane protein and its interactions ...
Nisius, Lydia
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Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis [PDF]
, 2009 Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been ...
Rossol, Manuela +6 more
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Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members
eLife, 2019 HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil +12 more
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CCR5 is a potential therapeutic target for cancer.
, 2021 INTRODUCTION Chemokines and their cognate receptors play a major role in modulating inflammatory responses. Depending on their ligand binding, chemokine receptors can stimulate both immune activating and inhibitory signaling pathways. The CC chemokine
Berger, Martin D., Hemmatazad, Hossein
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Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
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Gut Microbes, 2021 Men who have sex with men (MSM), regardless of HIV infection status, have an intestinal microbiome that is compositionally distinct from men who have sex with women (MSW) and women.
Eiko Yamada +12 more
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The role of CCR5 in HCV infection [PDF]
European Journal of Medical Research, 2010 Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes. The CCR5 chemokine receptor is expressed on several cells of the immune system and has been suggested to ...
Coenen Martin, Nattermann Jacob
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No evidence for an association between the chemokine receptor 5 D32 polymorphism and multiple sclerosis susceptibility: A meta-analysis [PDF]
Scripta MedicaBackground/Aim: Numerous reports have been published on the association of the chemokine receptor 5 D32 genetic variation (rs333) with the risk of multiple sclerosis (MS), with results that are inconsistent.
Akbari Nazanin, Saadat Mostafa
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The biology of CCR5 and CXCR4 [PDF]
Current Opinion in HIV and AIDS, 2009 We discuss the current knowledge concerning the biology of CXCR4 and CCR5 and their roles in HIV-1 infection.Important research findings reported in the last 2 years have advanced our knowledge in the field of HIV coreceptors and pathogenesis. Novel methods have been used to crystallize two new members of the G-protein coupled receptors.
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Entanglement of CCR5 and Alzheimer’s Disease [PDF]
Frontiers in Aging Neuroscience, 2019 Although the mechanisms of Alzheimer's disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable participant in the cause of Alzheimer's disease; of this family, CCR5 is the most widely studied ...
Tianwen Li +5 more
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