Results 21 to 30 of about 58,061 (209)

Intratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responses

OncoImmunology, 2020
Our previous studies revealed tumor-infiltrating neutrophils (TINs) played dichotomous roles in different cancers, indicating diverse TINs subtypes might orchestrate anti-tumor immunity or immune evasion, respectively. This study aimed to investigate the
Zhuoyi Xiang, Quan Zhou, Han Zeng, Zewei Wang, Hongyu Zhang, Zhaopei Liu, Qiuren Huang, Yuan Chang, Qi Bai, Yu Xia, Yiwei Wang, Li Liu, Yu Zhu, Le Xu, Bo Dai, Jiajun Wang, Jianming Guo, Jiejie Xu   +17 more
doaj   +1 more source

Intestinal microbial communities and Holdemanella isolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5+ CD4+ T cells

Gut Microbes, 2021
Men who have sex with men (MSM), regardless of HIV infection status, have an intestinal microbiome that is compositionally distinct from men who have sex with women (MSW) and women.
Eiko Yamada, Casey G. Martin, Nancy Moreno-Huizar, Jennifer Fouquier, C. Preston Neff, Sara L. Coleman, Jennifer M. Schneider, Jonathan Huber, Nichole M. Nusbacher, Martin McCarter, Thomas B. Campbell, Catherine A. Lozupone, Brent E. Palmer   +12 more
doaj   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

, 2003
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Mack, Matthias, Vielhauer, Volker, Schlöndorff, Detlef, Luckow, Bruno   +5 more
core   +1 more source

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

eLife, 2019
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil, Patrick B Rapuano, Uchenna Ikediobi, Rebecca Leibowitz, Sameet Mehta, Ayse K Coskun, J Zachary Porterfield, Teagan D Lampkin, Vincent C Marconi, David Rimland, Bruce D Walker, Steven Deeks, Richard E Sutton   +12 more
doaj   +1 more source

Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-κB and upregulation of IL-1Ra in melanoma model. [PDF]

PLoS ONE, 2012
To evaluate the relevance of C-C chemokine receptor type 5 (CCR5) expression and tumor development, we compared melanoma growth in CCR5 knockout (CCR5(-/-)) mice and wild type (CCR5(+/+)) mice.
Ju Kyoung Song, Mi Hee Park, Dong-Young Choi, Hwan Soo Yoo, Sang Bae Han, Do Young Yoon, Jin Tae Hong   +6 more
doaj   +1 more source

CCR5+ T-Cells Homed to the Liver Exhibit Inflammatory and Profibrogenic Signatures in Chronic HIV/HCV-Coinfected Patients

Viruses, 2021
Liver fibrosis is accelerated in patients coinfected with hepatitis C virus and human immunodeficiency virus (HIV), compared with HCV monoinfected patients, although the underlying mechanisms are unknown. We hypothesize that T cells expressing the HIV co-
Shikha Shrivastava, Shyam Kottilil, Kenneth E. Sherman, Henry Masur, Lydia Tang   +4 more
doaj   +1 more source

Can gut microbiota of men who have sex with men influence HIV transmission?

Gut Microbes, 2020
Gaining a complete understanding of transmission risk factors will assist in efforts to reduce new HIV infections, especially within the disproportionally affected population of men who have sex with men (MSM).
Sara L. Coleman, C. Preston Neff, Sam X. Li, Abigail J.S. Armstrong, Jennifer M. Schneider, Sharon Sen, Blair Fennimore, Thomas B. Campbell, Catherine A. Lozupone, Brent E. Palmer   +9 more
doaj   +1 more source

People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells

Scientific Reports, 2022
CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune cells between people living with HIV (PLHIV) using combination antiretroviral therapy (cART) and HIV-uninfected controls, (2) relate CCR5 expression to viral reservoir ...
Louise E. van Eekeren, Vasiliki Matzaraki, Zhenhua Zhang, Lisa van de Wijer, Marc J. T. Blaauw, Marien I. de Jonge, Linos Vandekerckhove, Wim Trypsteen, Leo A. B. Joosten, Mihai G. Netea, Quirijn de Mast, Hans J. P. M. Koenen, Yang Li, André J. A. M. van der Ven   +13 more
doaj   +1 more source

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
de Lara, C, Zhang Yan, Hegedus Andrea, Karoliina Laamanen, Derek Macallan, de Lara Catherine, Peter Beverley, Laamanen Karoliina, Catherine de Lara (339229), Karoliina Laamanen (233571), Yan Zhang (8098), Worth Andrew, Laamanen, K, Andrew Worth, Andrea Hegedus, Hegedus, A, Beverley Peter, Andrew Worth (404365), Worth, A, Zhang, Y, Macallan, D, Andrea Hegedus (404366), Peter Beverley (404367), Macallan Derek, Beverley, P, Yan Zhang, Catherine de Lara, Derek Macallan (404368)   +27 more
core   +1 more source

CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RNA renders cells resistant to HIV-1 infection. [PDF]

PLoS ONE, 2014
CCR5, a coreceptor for HIV-1 entry, is a major target for drug and genetic intervention against HIV-1. Genetic intervention strategies have knocked down CCR5 expression levels by shRNA or disrupted the CCR5 gene using zinc finger nucleases (ZFN) or ...
Weiming Wang, Chaobaihui Ye, Jingjing Liu, Di Zhang, Jason T Kimata, Paul Zhou   +5 more
doaj   +1 more source