Results 31 to 40 of about 58,061 (209)

Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue [PDF]

, 2004
Identification of cellular factors involved in HIV-1 entry and transmission at mucosal surfaces is critical for understanding viral pathogenesis and development of effective prevention strategies. Here we describe the evaluation of HIV-1 entry inhibitors
Ines Frank, Griffin, GE, Griffin, George E., George E. Griffin, Santos, John J., John P. Moore, Robin J. Shattock, Shattock, Robin J., Watts, Patricia, John J. Santos, Patricia Watts, Santos, JJ, Shattock, RJ, Vennansha Williams, Williams, V, Moore, JP, Williams, Vennansha G., Robbiani, Melissa, Hu, Qinxue, Qinxue Hu, Pope, M, Melissa Pope, Moore, John P., Frank, Ines, Hu, Q, Frank, I, Watts, P   +26 more
core   +1 more source

Differential Pathogenicity of SHIV KB9 and 89.6 Env Correlates with Bystander Apoptosis Induction in CD4+ T cells

Viruses, 2019
SHIV variants KB9 and 89.6 show differential pathogenesis in primate models with KB9 causing rapid CD4 decline while 89.6 failing to induce disease.
Tugba Mehmetoglu-Gurbuz, Anjali Joshi, Himanshu Garg   +2 more
doaj   +1 more source

Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells.
S.M. Mohaddes Ardebili
doaj  

Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus‐infected rhesus macaques

Brain and Behavior, 2023
Background C‐C chemokine receptor 5 (CCR5) is a major coreceptor for Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) cell entry; however, its role in brain pathogenesis is largely understudied.
Julian B. Hattler, Derek L. Irons, Jiangtao Luo, Woong‐Ki Kim   +3 more
doaj   +1 more source

Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation

, 2020
Background: Contextual fear conditioning (CFC) is a rodent model that induces a high and long-lasting level of conditioning associated with traumatic memory formation; this behavioral paradigm resembles many characteristics of posttraumatic stress ...
Loscertales, María, Merino Martín, José Joaquín, Muñetón-Gomez, Vilma, Pérez-Izquierdo, María Ángeles, Toledano Gasca, Adolfo, Muñetón-Gómez, César   +5 more
core   +1 more source

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry [PDF]

, 2010
R5X4 HIV-1 has impaired utilization of CCR5 on primary CD4+ lymphocytes but the mechanisms responsible are not well defined. Using a panel of diverse R5X4 Envs we identified a spectrum of CCR5 use on CD4+ lymphocytes.
Lee, Fang-Hua, Gray, Lachlan, Kienzle, Martha F., Lee, Benhur, Yi, Yanjie, Collman, Ronald G., Loftin, Lamorris M., Gorry, Paul R.   +7 more
core   +1 more source

Investigation of the Correlation Between the Polymorphism/Expression Level of RANTES and Its Receptor CCR5 Gene Promoter and Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2023
Jie Chen,1,* Weichang Guo,2,* Hejia Yin,1 Liju Ma,3 Shaoyou Li,4 Huifang Li1 1Department of Diabetes, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Department of Physical Education ...
Chen J, Guo W, Yin H, Ma L, Li S, Li H
doaj  

Cysteine-cysteine chemokine receptor 5 (CCR5) profile of HIV-infected subjects attending University of Calabar Teaching Hospital, Calabar, Southern Nigeria

BMC Infectious Diseases, 2020
Background Cysteine-cysteine chemokine receptor 5 is the main HIV co-receptor involved in the virus and cell-to-cell spread. A variant of the CCR5 gene known as CCR5-Δ32 which is a product of 32 base pair deletion in the gene plays critical role in the ...
Ekerette Friday Ekere, Monday F. Useh, Henshaw Uchechi Okoroiwu, Tatfeng Youtchou Mirabeau   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

CCR5 status and metastatic progression in colorectal cancer

OncoImmunology, 2019
Multiple reports have highlighted the importance of the local immunological cellular composition (i.e. the density of effector T cells and macrophage polarization state) in predicting clinical outcome in advanced metastatic stage of colorectal cancer ...
Meggy Suarez-Carmona, Pornpimol Chaorentong, Jakob Nikolas Kather, Rebecca Rothenheber, Azaz Ahmed, Anna Berthel, Anita Heinzelmann, Rodrigo Moraleda, Nektarios A. Valous, Zeynep Kosaloglu, Rosa Eurich, Jana Wolf, Silke Grauling-Halama, Michael Hundemer, Felix Lasitschka, Fee Klupp, Christoph Kahlert, Alexis Ulrich, Martin Schneider, Christine Falk, Dirk Jäger, Inka Zoernig, Niels Halama   +22 more
doaj   +1 more source