Results 31 to 40 of about 37,511 (242)

INVESTIGATION OF THE EFFECTS OF JUGLONE AND CISPLATIN ON BREAST CANCER CELL LINES

International Journal of Health Services Research and Policy
Breast cancer is one of the most commonly diagnosed malignancies worldwide, accounting for approximately 11% of all cancer-related deaths. Cisplatin induces DNA damage, thereby leading to apoptotic cell death, while juglone, a phytochemical compound ...
Selda Şimşek, Buket Er Urgancı, Sacide Çakal   +2 more
doaj   +1 more source

CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice

Molecular Brain, 2020
It remains controversial whether circulating monocytes expressing CCR2 infiltrate the central nervous system (CNS) and contribute to pathogenicity of amyotrophic lateral sclerosis (ALS).
Hiroyasu Komiya, Hideyuki Takeuchi, Yuki Ogawa, Yuki Hatooka, Keita Takahashi, Atsuko Katsumoto, Shun Kubota, Haruko Nakamura, Misako Kunii, Mikiko Tada, Hiroshi Doi, Fumiaki Tanaka   +11 more
doaj   +1 more source

Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus

Scientific Reports, 2023
Generalized status epilepticus (SE) triggers a robust neuroinflammatory response involving reactive astrocytosis, activation of brain-resident microglia, and brain infiltration of CCR2+ monocytes.
Carlos Alemán-Ruiz, Wenyi Wang, Ray Dingledine, Nicholas H. Varvel   +3 more
doaj   +1 more source

The CCR2⁺ Monocyte Subsets Increase in Obese Boys but Not Girls with Abnormally High Carotid Intima-Media Thickness: A Pilot Study

Journal of Cardiovascular Development and Disease, 2022
The differential contribution of monocyte subsets expressing the C-C chemokine receptor 2 (CCR2) to subclinical atherosclerosis in girls and boys is unclear.
María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos López-Alvarenga, José Luis Pérez-Hernández, Gloria Queipo-García   +11 more
doaj   +1 more source

Malarial pigment-induced lipoperoxidation, inhibited motility and decreased CCR2 and TNFR1/2 expression on human monocytes

Redox Experimental Medicine
Objective: Malaria remains an important life-threatening disease that provokes a complex immune response, marked by an initial immune boost followed by long-term suppression, warranting further study.
Oleksii Skorokhod, Valentina Barrera, Elena Valente, Daniela Ulliers, Koji Uchida, Evelin Schwarzer   +5 more
doaj   +1 more source

Bioinformatically analyzed relationships between specific human genes associated with HIV attachment

Инфекция и иммунитет
Introduction. Assessing interaction between the human immunodeficiency virus (HIV) and human factors is crucial for understanding the disease pathogenesis. HIV triggers an immune response that involves numerous cellular and molecular processes related to
Vladimir S. Davydenko, Yu. V. Ostankova, A. N. Schemelev, E. V. Anufrieva, V. V. Kushnareva, A. A. Totolian   +5 more
doaj   +1 more source

Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus

Journal of Neuroinflammation, 2009
Background Neuroinflammation occurs after seizures and is implicated in epileptogenesis. CCR2 is a chemokine receptor for CCL2 and their interaction mediates monocyte infiltration in the neuroinflammatory cascade triggered in different brain pathologies.
Katki Khurshed, Arisi Gabriel M, Foresti Maira L, Montañez Andres, Sanchez Russell M, Shapiro Lee A   +5 more
doaj   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis. [PDF]

PLoS ONE, 2012
The CCL2 CCR2 axis is likely to contributes to the development and progression of cancer diseases by two major mechanisms; autocrine effect of CCL2 as a survival/growth factor for CCR2+ cancer cells and, the attraction of CCR2+ CX₃CR1+tumor associated ...
Liat Izhak, Gizi Wildbaum, Steffen Jung, Avi Stein, Yuval Shaked, Nathan Karin   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source