Results 31 to 40 of about 45,468 (163)

Bioinformatically analyzed relationships between specific human genes associated with HIV attachment

Инфекция и иммунитет
Introduction. Assessing interaction between the human immunodeficiency virus (HIV) and human factors is crucial for understanding the disease pathogenesis. HIV triggers an immune response that involves numerous cellular and molecular processes related to
Vladimir S. Davydenko, Yu. V. Ostankova, A. N. Schemelev, E. V. Anufrieva, V. V. Kushnareva, A. A. Totolian   +5 more
doaj   +1 more source

Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus

Scientific Reports, 2023
Generalized status epilepticus (SE) triggers a robust neuroinflammatory response involving reactive astrocytosis, activation of brain-resident microglia, and brain infiltration of CCR2+ monocytes.
Carlos Alemán-Ruiz, Wenyi Wang, Ray Dingledine, Nicholas H. Varvel   +3 more
doaj   +1 more source

AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages. [PDF]

PLoS ONE, 2016
C-C chemokine receptor 2 (Ccr2) is a key pro-inflammatory marker of classic (M1) macrophage activation. Although Ccr2 is known to be expressed both constitutively and inductively, the full regulatory mechanism of its expression remains unclear.
Fumiaki Kumase, Kimio Takeuchi, Yuki Morizane, Jun Suzuki, Hidetaka Matsumoto, Keiko Kataoka, Ahmad Al-Moujahed, Daniel E Maidana, Joan W Miller, Demetrios G Vavvas   +9 more
doaj   +1 more source

CCR2 expression correlates with prostate cancer progression [PDF]

, 2007
Although the primary role of chemokines and their receptors is controlling the trafficking of leukocytes during inflammatory responses, they also play pleoitropic roles in cancer development.
Zhi Yao, Zhang, Jian, Zhong Cai, Yao, Zhi, Xiao, Guozhi, Keller, Evan T., Cai, Zhong, Yi Lu, Yulin Liu, Jian Zhang, Evan T. Keller, Lu, Yi, Liu, Yulin, Guozhi Xiao   +13 more
core   +1 more source

CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice

Molecular Brain, 2020
It remains controversial whether circulating monocytes expressing CCR2 infiltrate the central nervous system (CNS) and contribute to pathogenicity of amyotrophic lateral sclerosis (ALS).
Hiroyasu Komiya, Hideyuki Takeuchi, Yuki Ogawa, Yuki Hatooka, Keita Takahashi, Atsuko Katsumoto, Shun Kubota, Haruko Nakamura, Misako Kunii, Mikiko Tada, Hiroshi Doi, Fumiaki Tanaka   +11 more
doaj   +1 more source

The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice

Arthritis Research & Therapy, 2021
Background C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM).
Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller   +6 more
doaj   +1 more source

Сhanges of the functional phenotype of circulating monocytes during pregnancy

Медицинская иммунология
Rearrangement of the immune system during pregnancy is a strictly controlled, dynamic process in which the first and third trimesters are, respectively, pro-inflammatory, and anti-inflammatory periods.
N. G. Bukhtueva, O. Yu. Leplina, E. Ya. Shevela, M. A. Tikhonova, N. M. Pasman, A. A. Ostanin, E. R. Chernykh   +6 more
doaj   +1 more source

Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus

Journal of Neuroinflammation, 2009
Background Neuroinflammation occurs after seizures and is implicated in epileptogenesis. CCR2 is a chemokine receptor for CCL2 and their interaction mediates monocyte infiltration in the neuroinflammatory cascade triggered in different brain pathologies.
Katki Khurshed, Arisi Gabriel M, Foresti Maira L, Montañez Andres, Sanchez Russell M, Shapiro Lee A   +5 more
doaj   +1 more source

The CCR2⁺ Monocyte Subsets Increase in Obese Boys but Not Girls with Abnormally High Carotid Intima-Media Thickness: A Pilot Study

Journal of Cardiovascular Development and Disease, 2022
The differential contribution of monocyte subsets expressing the C-C chemokine receptor 2 (CCR2) to subclinical atherosclerosis in girls and boys is unclear.
María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos López-Alvarenga, José Luis Pérez-Hernández, Gloria Queipo-García   +11 more
doaj   +1 more source

Figure 1: CCR2

, 2019
(A) Mouse LV gene expression of CCR2 chemokine ligands (left) and proinflammatory and anti-inflammatory cytokines (right) 1 week after transverse aortic constriction (TAC) or sham operation.
Sumanth D. Prabhu (549964), Bindiya Patel (3709933), Mohamed Ameen Ismahil (3709942), Matthias Mack (148002), Shyam S. Bansal (3709936), Tariq Hamid (3709939), Gregg Rokosh (315012)   +6 more
core   +1 more source