Results 11 to 20 of about 45,468 (163)

Fluorescent ligands targeting the intracellular allosteric binding site of the chemokine receptor CCR2 [PDF]

, 2022
Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays.
Dorothee, Weikert, Max E., Huber, Lara, Toy, Maximilian F., Schmidt, Matthias, Schiedel   +4 more
core   +2 more sources

Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by facilitating M2 polarization via CCL2/CCR2 axis and further inducing formation of regulatory CCR2 + CD4 + T cells

Stem Cell Research & Therapy
Background Our previous study revealed that mesenchymal stem cells (MSCs) can secrete large amounts of the chemokine CCL2 under inflammatory conditions and alleviate idiopathic pneumonia syndrome (IPS) by promoting regulatory CCR2 + CD4 + T-cell ...
Chao Xue, Wei Liu, Yuan Li, Yue Yin, Bo Tang, Jinye Zhu, Yujun Dong, Huihui Liu, Hanyun Ren   +8 more
doaj   +2 more sources

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC   +11 more
core   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

, 2003
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Mack, Matthias, Vielhauer, Volker, Schlöndorff, Detlef, Luckow, Bruno   +5 more
core   +1 more source

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis [PDF]

, 2017
Background and aim. Obese patients with chronic inflammation in white adipose tissue (WAT) have an increased risk of developing non-alcoholic steatohepatitis (NASH).
Hoek, A.M. van den, Petra Mulder (462809), Kleenann, R., Kleemann, R., Robert Kleemann (47402), Anita M. van den Hoek (186737), Mulder, P.   +6 more
core   +2 more sources

Endothelial CCR2 Promotes Pulmonary Metastasis [PDF]

, 2015
Nine out of ten cancer patients die due to metastasis. The generation of them is dependent on several factors, including the recruitment of inflammatory monocytes and activation of endothelial cells at the pre-metastatic niche. It is at these sites where
Roblek, Marko
core   +2 more sources

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2 [PDF]

, 2017
Chemokines and their receptors collectively orchestrate the trafficking of leukocytes in normal immune function and inflammatory diseases. Different chemokines can induce distinct responses at the same receptor.
Jessica L. Bridgford, Pfleger, Kevin D. G., Meritxell Canals, Bridgford, Jessica L., Parker, Bradyn J., Huang, Cheng, Zil E. Huma, Stone, Martin J., Martin J. Stone, Pazhamalil, Jiann G., Julie Sanchez, Porebski, Benjamin T., Canals, Meritxell, Herman D. Lim, J. Robert Lane, Jiann G. Pazhamalil, Bradyn J. Parker, Lane, J. Robert, Benjamin T. Porebski, Huma, Zil E., Kevin D. G. Pfleger, Lim, Herman D., Cheng Huang, Sanchez, Julie   +23 more
core   +1 more source

Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression

OncoImmunology, 2020
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that promote tumor progression by inhibiting anti-tumor immunity and may be the cause of patient resistance to immune checkpoint inhibitors (ICIs).
Zhiqi Xie, Tamami Ikegami, Yukio Ago, Naoki Okada, Masashi Tachibana   +4 more
doaj   +1 more source

Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea

Clinical, Cosmetic and Investigational Dermatology, 2021
Cuie Gao,1 Lan Ge,1 Dewei Chen,2 Mengjie Zhang,2 Li Zhao,2 Wenying Liu,1 Shuguang Chen,1 Juan Wang,1 Cunjian Zhou,1 Xingwang Zhao,1 Shifei Li,1 Zhiqiang Song,1 Jian Li1 1Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing ...
Gao C, Ge L, Chen D, Zhang M, Zhao L, Liu W, Chen S, Wang J, Zhou C, Zhao X, Li S, Song Z, Li J   +12 more
doaj  

Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice. [PDF]

PLoS ONE, 2016
CCR2 is a chemokine receptor expressed on the surface of blood leukocytes, particularly «Ly6Chi» inflammatory monocytes and microglia. Signaling through this receptor is thought to influence the immune activity of microglia as well as monocytes egress ...
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin   +4 more
doaj   +1 more source