Results 11 to 20 of about 37,511 (242)

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Pharmacological Inhibition of CCR2 Signaling Exacerbates Exercise-Induced Inflammation Independently of Neutrophil Infiltration and Oxidative Stress

Immuno, 2021
Although exercise-induced humoral factors known as exerkines benefit systemic health, the role of most exerkines has not been investigated. Monocyte chemoattractant protein-1 (MCP-1) is a representative chemokine whose circulating concentrations increase
Takaki Tominaga, Jiapeng Huang, Katsuhiko Suzuki   +2 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression

OncoImmunology, 2020
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that promote tumor progression by inhibiting anti-tumor immunity and may be the cause of patient resistance to immune checkpoint inhibitors (ICIs).
Zhiqi Xie, Tamami Ikegami, Yukio Ago, Naoki Okada, Masashi Tachibana   +4 more
doaj   +1 more source

Possible association between expression of chemokine receptor-2 (CCR2) and amyotrophic lateral sclerosis (ALS) patients of North India. [PDF]

PLoS ONE, 2012
BACKGROUND AND OBJECTIVES: We earlier reported elevated chemokine ligand-2 (CCL2) in Indian amyotrophic lateral sclerosis (ALS) patients. We now analysed chemokine receptor-2 (CCR2), the receptor of CCL2, in these ALS patients.
Pawan K Gupta, Sudesh Prabhakar, Neel K Sharma, Akshay Anand   +3 more
doaj   +1 more source

Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model

Journal of Pain Research, 2022
Megumi Sumizono,1,2 Yushin Yoshizato,1 Ryohei Yamamoto,1 Takaki Imai,1 Akira Tani,2 Kazuki Nakanishi,2 Tomomi Nakakogawa,2 Teruki Matsuoka,2 Ryoma Matsuzaki,2 Takashi Tanaka,3 Harutoshi Sakakima2 1Department of Rehabilitation, Kyushu University of ...
Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T, Matsuzaki R, Tanaka T, Sakakima H   +10 more
doaj  

Involvement of MST1/mTORC1/STAT1 activity in the regulation of B‐cell receptor signalling by chemokine receptor 2

Clinical and Translational Medicine, 2022
Background CCR2 is involved in maintaining immune homeostasis and regulating immune function. This study aims to elucidate the mechanism by which CCR2 regulates B‐cell signalling.
Yingzi Zhu, Heng Gu, Lu Yang, Na Li, Qiuyue Chen, Danqing Kang, Shengyan Lin, Yukai Jing, Panpan Jiang, Qianglin Chen, Li Luo, Ju Liu, Jiang Chang, Zhenzhen Li, Yi Wang, Xin Dai, Heather Miller, Lisa S. Westerberg, Chan‐Sik Park, Masato Kubo, Quan Gong, Lingli Dong, Chaohong Liu   +22 more
doaj   +1 more source

Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy

Zhongliu Fangzhi Yanjiu, 2019
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes.
LU Xiaomei, FU Jiejun
doaj   +1 more source

CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]

Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy, Borsig, Lubor, Heikenwalder, Mathias   +2 more
openaire   +4 more sources

Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells.
S.M. Mohaddes Ardebili
doaj