Results 21 to 30 of about 37,511 (242)

CCR2 promotes hepatic fibrosis in mice # [PDF]

Hepatology, 2009
Abstract Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of CCR2, the receptor for monocyte chemoattractant protein (MCP)-1, MCP-2, and MCP-3, in hepatic ...
Seki, E., De Minicis, S., Inokuchi, S., Taura, K., Miyai, K., van Rooijen, N., Schwabe, R.F., Brenner, D.A.   +7 more
openaire   +3 more sources

Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea

Clinical, Cosmetic and Investigational Dermatology, 2021
Cuie Gao,1 Lan Ge,1 Dewei Chen,2 Mengjie Zhang,2 Li Zhao,2 Wenying Liu,1 Shuguang Chen,1 Juan Wang,1 Cunjian Zhou,1 Xingwang Zhao,1 Shifei Li,1 Zhiqiang Song,1 Jian Li1 1Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing ...
Gao C, Ge L, Chen D, Zhang M, Zhao L, Liu W, Chen S, Wang J, Zhou C, Zhao X, Li S, Song Z, Li J   +12 more
doaj  

IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. [PDF]

PLoS ONE, 2013
Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis.
Shannon K Bromley, Ryan P Larson, Steven F Ziegler, Andrew D Luster   +3 more
doaj   +1 more source

Diminished Non-Classical Monocytes in the Blood Associate with Disease Severity in Alcoholic Hepatitis

Clinical and Experimental Gastroenterology, 2021
Elisabeth Busk Rasmussen,1 Lotte Lindgreen Eriksen,2 Stinne Ravn Greisen,1 Anne Louise Hansen,1 Mikkel Carstensen,1 Thomas Damgaard Sandahl,2 Sidsel Støy,2 Tue Wenzel Kragstrup1,3 1Department of Biomedicine, Aarhus University, Aarhus, Denmark ...
Rasmussen EB, Eriksen LL, Greisen SR, Hansen AL, Carstensen M, Sandahl TD, Støy S, Kragstrup TW   +7 more
doaj  

Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy

HIV Research & Clinical Practice, 2019
Background: Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor ...
S. Bowler, C. Siriwardhana, B. L. Mitchell, M. L. D’Antoni, D. Ogata-Arakaki, S. Souza, R. Yee, L. M. A. Gangcuangco, D. C. Chow, L. C. Ndhlovu, C. Shikuma   +10 more
doaj   +1 more source

The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice

Arthritis Research & Therapy, 2021
Background C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM).
Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller   +6 more
doaj   +1 more source

Ccr2 suppression by minocycline in Cx3cr1/Ccr2-visualized inherited retinal degeneration [PDF]

, 2020
Abstract Retinal inflammation accelerates photoreceptor cell death (PCD) caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has previously been reported to show PCD rescue effect in retinal degeneration. The purpose of this study was to assess the effect of minocycline
Ryo Terauchi, Hideo Kohno, Sumiko Watanabe, Saburo Saito, Akira Watanabe, Tadashi Nakano   +5 more
openaire   +1 more source

Targeting the CCL2–CCR2 axis for atheroprotection

European Heart Journal, 2022
AbstractDecades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for lowering residual vascular risk.
Marios K Georgakis, Jürgen Bernhagen, Laura H Heitman, Christian Weber, Martin Dichgans   +4 more
openaire   +5 more sources

CCL2/CCR2 signaling in cancer pathogenesis [PDF]

Cell Communication and Signaling, 2020
AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao, Jaydutt V. Vadgama, Piwen Wang   +2 more
openaire   +3 more sources

AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages. [PDF]

PLoS ONE, 2016
C-C chemokine receptor 2 (Ccr2) is a key pro-inflammatory marker of classic (M1) macrophage activation. Although Ccr2 is known to be expressed both constitutively and inductively, the full regulatory mechanism of its expression remains unclear.
Fumiaki Kumase, Kimio Takeuchi, Yuki Morizane, Jun Suzuki, Hidetaka Matsumoto, Keiko Kataoka, Ahmad Al-Moujahed, Daniel E Maidana, Joan W Miller, Demetrios G Vavvas   +9 more
doaj   +1 more source