Results 21 to 30 of about 45,468 (163)

Diminished Non-Classical Monocytes in the Blood Associate with Disease Severity in Alcoholic Hepatitis

Clinical and Experimental Gastroenterology, 2021
Elisabeth Busk Rasmussen,1 Lotte Lindgreen Eriksen,2 Stinne Ravn Greisen,1 Anne Louise Hansen,1 Mikkel Carstensen,1 Thomas Damgaard Sandahl,2 Sidsel Støy,2 Tue Wenzel Kragstrup1,3 1Department of Biomedicine, Aarhus University, Aarhus, Denmark ...
Rasmussen EB, Eriksen LL, Greisen SR, Hansen AL, Carstensen M, Sandahl TD, Støy S, Kragstrup TW   +7 more
doaj  

Involvement of MST1/mTORC1/STAT1 activity in the regulation of B‐cell receptor signalling by chemokine receptor 2

Clinical and Translational Medicine, 2022
Background CCR2 is involved in maintaining immune homeostasis and regulating immune function. This study aims to elucidate the mechanism by which CCR2 regulates B‐cell signalling.
Yingzi Zhu, Heng Gu, Lu Yang, Na Li, Qiuyue Chen, Danqing Kang, Shengyan Lin, Yukai Jing, Panpan Jiang, Qianglin Chen, Li Luo, Ju Liu, Jiang Chang, Zhenzhen Li, Yi Wang, Xin Dai, Heather Miller, Lisa S. Westerberg, Chan‐Sik Park, Masato Kubo, Quan Gong, Lingli Dong, Chaohong Liu   +22 more
doaj   +1 more source

Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy

Zhongliu Fangzhi Yanjiu, 2019
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes.
LU Xiaomei, FU Jiejun
doaj   +1 more source

IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. [PDF]

PLoS ONE, 2013
Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis.
Shannon K Bromley, Ryan P Larson, Steven F Ziegler, Andrew D Luster   +3 more
doaj   +1 more source

Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model

Journal of Pain Research, 2022
Megumi Sumizono,1,2 Yushin Yoshizato,1 Ryohei Yamamoto,1 Takaki Imai,1 Akira Tani,2 Kazuki Nakanishi,2 Tomomi Nakakogawa,2 Teruki Matsuoka,2 Ryoma Matsuzaki,2 Takashi Tanaka,3 Harutoshi Sakakima2 1Department of Rehabilitation, Kyushu University of ...
Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T, Matsuzaki R, Tanaka T, Sakakima H   +10 more
doaj  

INVESTIGATION OF THE EFFECTS OF JUGLONE AND CISPLATIN ON BREAST CANCER CELL LINES

International Journal of Health Services Research and Policy
Breast cancer is one of the most commonly diagnosed malignancies worldwide, accounting for approximately 11% of all cancer-related deaths. Cisplatin induces DNA damage, thereby leading to apoptotic cell death, while juglone, a phytochemical compound ...
Selda Şimşek, Buket Er Urgancı, Sacide Çakal   +2 more
doaj   +1 more source

CCR2-associated influx of T cells and monocytes/macrophages in the liver during SIV infection.

, 2018
A) PBMC and liver cell suspensions were first gating on single, live, CD45+ cells followed by identification of T cells by CD3 expression and monocytes/macrophages by CD14 expression.
Andrew D. Miller (328799), Ann Chahroudi (531553), Jean Chang (89849), Charlene J. Miller (4872724), Nichole R. Klatt (203174), Matthew P. Wood (119432), William J. Bosche (4003496), Cole Fisher (4872718), Bridget S. Fisher (492119), Richard R. Green (4872721), Maud Mavigner (257553), Rachel R. Brown (4872727), Michael Gale Jr. (106064), Tiffany Hensley-McBain (4872715), Jeffrey D. Lifson (140183), Guido Silvestri (94156), Donald L. Sodora (94155)   +16 more
core   +1 more source

Malarial pigment-induced lipoperoxidation, inhibited motility and decreased CCR2 and TNFR1/2 expression on human monocytes

Redox Experimental Medicine
Objective: Malaria remains an important life-threatening disease that provokes a complex immune response, marked by an initial immune boost followed by long-term suppression, warranting further study.
Oleksii Skorokhod, Valentina Barrera, Elena Valente, Daniela Ulliers, Koji Uchida, Evelin Schwarzer   +5 more
doaj   +1 more source

Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells.
S.M. Mohaddes Ardebili
doaj  

Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy

HIV Research & Clinical Practice, 2019
Background: Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor ...
S. Bowler, C. Siriwardhana, B. L. Mitchell, M. L. D’Antoni, D. Ogata-Arakaki, S. Souza, R. Yee, L. M. A. Gangcuangco, D. C. Chow, L. C. Ndhlovu, C. Shikuma   +10 more
doaj   +1 more source