Results 51 to 60 of about 27,078 (238)

Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation

Thrombosis Journal, 2010
Objectives The chemokine receptors CCR2 and CX3CR1 are important in the development of coronary artery disease. The purpose of this study is to analyze the effect of a novel CCR2 inhibitor in conjunction with CX3CR1 deletion on vascular inflammation ...
Jerath Maya R, Liu Peng, Struthers Mary, DeMartino Julie A, Peng Roche, Peterson Laurence B, Cumiskey Anne-Marie, Yang Lihu, Rojas Mauricio, Patel Dhavalkumar D, Fong Alan M   +10 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 [PDF]

Proceedings of the National Academy of Sciences, 2003
Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a marked attenuation of monocyte recruitment in response to various inflammatory stimuli and a reduction of inflammatory lesions in models of demyelinating disease. In the present study, we compared nociceptive responses in inflammatory and neuropathic models of pain in
Catherine, Abbadie, Jill A, Lindia, Anne Marie, Cumiskey, Larry B, Peterson, John S, Mudgett, Ellen K, Bayne, Julie A, DeMartino, D Euan, MacIntyre, Michael J, Forrest   +8 more
openaire   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Differential signaling mechanisms regulate expression of CC chemokine receptor-2 during monocyte maturation

Journal of Inflammation, 2005
Background Peripheral blood monocytes and monocyte-derived macrophages are key regulatory components in many chronic inflammatory pathologies of the vasculature including the formation of atherosclerotic lesions.
Lutz Marin, Phillips Roderick J, Premack Brett   +2 more
doaj   +1 more source

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks [PDF]

FEMS Immunology & Medical Microbiology, 2000
The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a ...
A, Papa, E, Papadimitriou, G, Adwan, J P, Clewley, N, Malissiovas, I, Ntoutsos, S, Alexiou, A, Antoniadis   +7 more
openaire   +2 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

CX3CR1 and CCR2: dynamic myeloid cell states across inflammatory diseases with implications for oral health and disease

Frontiers in Immunology
Chemokine receptor-mediated immune cell trafficking is a fundamental determinant of inflammatory disease outcomes. Among chemokine receptors, CCR2 and CX3CR1 represent two functionally distinct but interconnected axes that regulate inflammatory monocyte ...
Yun-Ji Lim, Yun-Ji Lim, Tae Sung Kim, Tae Sung Kim   +3 more
doaj   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Polymorphism of CC chemokine receptors CCR2 and CCR5 in Crohn's disease

Immunology Letters, 2001
Crohn's disease (CD) is a chronic inflammatory disease of the intestine that is characterized by mononuclear cell infiltration and a predominant Th1 lymphocyte response. We tested the hypothesis that CC chemokine receptors CCR2 and CCR5 might be important in the regulation of the intestinal immune response in this disease, and we speculated that ...
Herfarth, H., Pollok-Kopp, B., Goke, M., Press, A., Oppermann, Martin   +4 more
openaire   +3 more sources