Results 71 to 80 of about 27,199 (232)

The Effects of Deferoxamine on the Up regulation of Chemokine Receptor 2 in Bone Marrow Stromal Stem Cells

Otorhinolaryngology and Facial Plastic Surgery, 2017
Background: Bone marrow stromal stem cells (BMSCs) are non-hematopoietic, stromal cellsthat can differentiate into mesenchymal and other type of tissues. The BMSCs have properties that make them ideal candidates for tissue engineering. The present study
Marjan Sadeghi, Fatemeh Fadaee Fathabadi, Mohsen Noorozian, Somayeh Niknazar, Hadi Azimi, Hojjat-Allah Abbaszadeh   +5 more
doaj   +1 more source

Polymorphism of CC chemokine receptors CCR2 and CCR5 in Crohn's disease

Immunology Letters, 2001
Crohn's disease (CD) is a chronic inflammatory disease of the intestine that is characterized by mononuclear cell infiltration and a predominant Th1 lymphocyte response. We tested the hypothesis that CC chemokine receptors CCR2 and CCR5 might be important in the regulation of the intestinal immune response in this disease, and we speculated that ...
Herfarth, H., Pollok-Kopp, B., Goke, M., Press, A., Oppermann, Martin   +4 more
openaire   +3 more sources

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines

Nature Communications
Human Th17/type 17 cells express the chemokine receptor CCR6, but the functions of CCR6 and other chemokine receptors in human type 17 Th cell extravasation have not been fully delineated.
Farhat Parween, Satya P. Singh, Nausheen Kathuria, Hongwei H. Zhang, Shinji Ashida, Francisco A. Otaizo-Carrasquero, Amirhossein Shamsaddini, Paul J. Gardina, Sundar Ganesan, Juraj Kabat, Hernan A. Lorenzi, Deanna J. Riley, Timothy G. Myers, Stefania Pittaluga, Bibiana Bielekova, Joshua M. Farber   +15 more
doaj   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Consumer Cultural Renaissance: Conceptualisation, Scale Development, and Validation

Psychology &Marketing, EarlyView.
ABSTRACT As incessant globalisation leads to the pervasive erosion of traditional Asian culture by Western consumerism, a recent phenomenon has emerged that allures Asian consumers to reconnect with their traditional culture via consumption. We postulate that this behaviour is rooted in a self‐identity, consumer cultural renaissance (CCR), that has not
Richard Lee, Huda Khan, Jianyao Li, Muhammad Rashid Saeed   +3 more
wiley   +1 more source

Frequency of mutation CCR2-64I chemokine gene receptor, which is associated with delayed progression to AIDS in people from western region of Ukraine

Фактори експериментальної еволюції організмів, 2013
Aims. The rate of progression of HIV-1 disease exhibits a remarkable variation among different individuals. Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease.
M. Ya. Tyrkus
doaj  

CCR2 (chemokine (C-C motif) receptor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on CCR2 (chemokine (C-C motif) receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source