Results 61 to 70 of about 27,078 (238)

Isolation and Structures of Novel Fungal Metabolites as Chemokine Receptor (CCR2) Antagonists [PDF]

The Journal of Antibiotics, 2005
The chemokine receptor, CCR2, is predominantly expressed on monocytes/macrophages, and on a subset of memory T cells. It binds to several CC type chemokines of the monocyte chemoattractant protein (MCP) family of which MCP-1 exhibits the highest affinity.
Kithsiri B, Herath, Hiranthi, Jayasuriya, John G, Ondeyka, Jon D, Polishook, Gerald F, Bills, Anne W, Dombrowski, Angeles, Cabello, Pasquale P, Vicario, Hans, Zweerink, Ziqiang, Guan, Sheo B, Singh   +10 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors

Molecular Pain, 2007
Background Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated in demyelinating polyneuropathies ...
Monahan Patrick E, Li Baolin, Hamdouchi Chafiq, Lineswala Jayana, Henry Kenneth J, Miller Richard J, Ren Dongjun, Bhangoo Sonia, Chan David M, Ripsch Matthew S, White Fletcher A   +10 more
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Memorias do Instituto Oswaldo Cruz, 2016
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC).
Erinaldo Ubirajara Damasceno dos Santos, Géssica Dayane Cordeiro de Lima, Micheline de Lucena Oliveira, Sandra de Andrade Heráclio, Hildson Dornelas Angelo da Silva, Sergio Crovella, Maria de Mascena Diniz Maia, Paulo Roberto Eleutério de Souza/   +7 more
doaj   +1 more source

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

Novel direct effect of CCR2 receptor on follicle activation process

Frontiers in Endocrinology
IntroductionThe regulation of primordial follicle activation is crucial for maintaining ovarian function, the duration of the reproductive phase, and fertility in women; therefore, we propose as our general objective to determine the physiological role of the chemokine receptor CCR2 within the follicular activation process.MethodsOvarian cortex ...
Yamila Gamaleri, Delfina Sol Ferman, Alison Ting, Alison Ting, Eduardo Raúl Dascal, Alejandro Lomniczi, Juan Pablo Jaworski, Marina Cinthia Peluffo   +7 more
openaire   +5 more sources

CCR2 (chemokine (C-C motif) receptor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on CCR2 (chemokine (C-C motif) receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources