Results 11 to 20 of about 27,078 (238)

Pharmacological and Genetic Targeting of Inflammatory Chemokine Receptors CCR1, CCR2, and CCR5 in Atherosclerosis: A Systematic Review and Meta‐Analysis of Preclinical Studies [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inflammatory chemokine receptors encompassing CCR1, CCR2, CCR3, and CCR5 orchestrate the recruitment of leukocytes during inflammation. In atherosclerosis, there is ongoing controversy surrounding the precise role each inflammatory chemokine ...
Mohsen Shoaran, Elisabetta Caiazzo, Moustafa I. Morsy, Danila Gurgone, Neil MacRitchie, Dario Bruzzese, Armando Ialenti, Tomasz J. Guzik, Gerard J. Graham, Pasquale Maffia   +9 more
doaj   +2 more sources

Activation of α7nAChR prevents maladaptive right ventricular remodeling via inhibiting the recruitment of CCR2+ macrophages in experimental pulmonary arterial hypertension [PDF]

Respiratory Research
Background The transition from adaptive to maladaptive right ventricular (RV) remodeling leads to RV failure (RVF), which is the strongest predictor of mortality in pulmonary arterial hypertension (PAH).
Keren Chen, Zhi Li, Jing Lu, Yingxin Guo, Huabao Xie, Fengxia Wu, Weifeng Wu   +6 more
doaj   +2 more sources

Surface N‐Glycosylation Dictates MSC‐EV Uptake and CCR2‐Driven Monocyte Recruitment to Inflamed Endothelium Under Shear Flow [PDF]

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EV) hold promising potential for immunomodulation and tissue regeneration, especially for treating ischemia‐reperfusion injury (IRI). However, their therapeutic use is hindered by challenges in tissue targeting and incomplete understanding of their functional mechanisms.
Marta Clos‐Sansalvador, Marta Monguió‐Tortajada, Sergio G. Garcia, Manuel Pérez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Diego Megías, Isabel Peset, Marcella Franquesa, Marta Hergueta‐Redondo, Hector Peinado, Francesc E. Borràs   +11 more
wiley   +2 more sources

Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice [PDF]

The Journal of Immunology, 2001
Abstract The chemokine receptors CCR2 and CCR5 play important roles in the recruitment of monocytes/macrophages and T cells. To better understand the role of both receptors in murine models of inflammatory diseases and to recognize potential problems when correlating these data to humans, we have generated mAbs against murine CCR2 and
M, Mack, J, Cihak, C, Simonis, B, Luckow, A E, Proudfoot, J, Plachý , H, Brühl, M, Frink, H J, Anders, V, Vielhauer, J, Pfirstinger, M, Stangassinger, D, Schlöndorff   +12 more
openaire   +2 more sources

Chemokine Receptors—Structure-Based Virtual Screening Assisted by Machine Learning

Pharmaceutics, 2023
Chemokines modulate the immune response by regulating the migration of immune cells. They are also known to participate in such processes as cell–cell adhesion, allograft rejection, and angiogenesis.
Paulina Dragan, Matthew Merski, Szymon Wiśniewski, Swapnil Ganesh Sanmukh, Dorota Latek   +4 more
doaj   +1 more source

A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

Journal of Neuroinflammation, 2018
Background A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing ...
Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio   +3 more
doaj   +1 more source

Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction [PDF]

Genes & Immunity, 2001
Our objective was to examine the association between myocardial infarction (MI) and two DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 bp deletion, (Delta)ccr5), defining if these polymorphisms influence the age for the onset of MI. A total of 214 patients with an age at the first MI episode
P, González, R, Alvarez, A, Batalla, J R, Reguero, V, Alvarez, A, Astudillo, G I, Cubero, A, Cortina, E, Coto   +8 more
openaire   +2 more sources

Selective loss of chemokine receptor expression on leukocytes after cell isolation.

PLoS ONE, 2012
Chemokine receptors are distinctively exposed on cells to characterize their migration pattern. However, little is known about factors that may regulate their expression. To determine the optimal conditions for an accurate analysis of chemokine receptors,
Juan C Nieto, Elisabet Cantó, Carlos Zamora, M Angels Ortiz, Cándido Juárez, Silvia Vidal   +5 more
doaj   +1 more source

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+/CX3CR1+ M-MDSCs into the tumor microenvironment in a redundant manner

Frontiers in Immunology, 2023
Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs, Christian J. Kreiger, Defang Luo, Guimei Tian, Julia S. Garcia, Loic P. Deleyrolle, Duane A. Mitchell, Jeffrey K. Harrison   +7 more
doaj   +1 more source

Analysis of CCR2 splice variant expression patterns and functional properties

Cell & Bioscience, 2022
Background C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell migration toward MCP-1 in ...
Hee-Kyung Park, Yun Hee Na, Huong Thi Nguyen, Lan Phuong Nguyen, Sunghoon Hurh, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang   +8 more
doaj   +1 more source