Results 261 to 270 of about 100,458 (303)

Nitration of CCL2 disrupts the tumor-protective function of CCL2 in bladder cancer

The Journal of Immunology, 2022
Abstract The chemokine CCL2 (C-C motif ligand 2) is best known for its ability to induce trafficking of immune cells by binding its primary receptor, CCR2. The recruitment of immunosuppressive monocytes by CCL2 promotes cancer in several tumor types. Surprisingly, we previously found an unanticipated protective role for CCL2 signaling in
Neelam Mukherjee, Niannian Ji, Zhen-Ju Shu, Tyler J Curiel, Robert S Svatek   +4 more
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ChemInform Abstract: Fluorination with Concomitant Cyclization of CCl2=N‐CCl2‐CCl2‐N=CCl2 with SbF5 and Molecular Structure of a 2‐Imidazolidinone Derivative.

ChemInform, 1987
AbstractFluorination of the perchlorodiazahexadiene (I) yields the imidazolines (III) or (IV), depending on the amount of the fluorinating agent SbF5 (II) used.
G. PAWELKE, H. + BUERGER, D. J. BRAUER, J. WILKE   +3 more
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Kinetics of the CCl2+ Br2 and CCl2+ NO2 reactions in the temperature range 266−365 K and reactivity of the CCl2 biradical

Chemical Physics Letters, 2008
Abstract The kinetics of the CCl2 + Br2 and CCl2 + NO2 reactions have been studied at temperatures between 266 and 365 K using laser photolysis/photoionization mass spectrometry. Dichloromethylene biradicals were produced by the pulsed laser photolysis of CCl4.
Arkke J. Eskola, Iwona Golonka, Matti P. Rissanen, Raimo S. Timonen   +3 more
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Ccl2 Determinations

Journal AWWA, 2008
On July 30, 2008, the U.S. Environmental Protection Agency (USEPA) finalized the regulatory determinations for 11 contaminants on the Second Contaminant Candidate List (CCL2). Considering the best available data, USEPA concluded that these contaminants occur infrequently at levels of public health concern in public water systems.
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Association of CCL2 Gene Variants with Osteoarthritis

Archives of Medical Research, 2019
The chemokine (C-C motif) Ligand 2 (CCL2)/CCR2 signaling was associated with macrophage accumulation, synovitis and cartilage damage in a mouse osteoarthritis (OA) model.Here a case-control study in a Chinese Han population was conducted to investigate the possible association between the CCL2 gene polymorphism and risk of OA.
Zhonghua, Xu, Jin, Li, Haoyu, Yang, Lifeng, Jiang, Xindie, Zhou, Yong, Huang, Nanwei, Xu   +6 more
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Simvastatin reduces CCL2 expression in monocyte-derived cells by induction of a repressive CCL2 chromatin state

Human Immunology, 2014
Statins exert anti-inflammatory characteristics, besides their lipid lowering properties, and may display beneficial effects for the treatment of inflammatory diseases. One possible explanation is that statins interfere in the deregulated gene transcription patterns associated with immune-mediated diseases, although the precise mechanism is not fully ...
Zannette, D.L., van Eggermond, M.C.J.A., Haasnoot, G., van den Elsen, P.J.   +3 more
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Synthesis of aromatic compounds of types ArCH2CH = CCl2 and Ar?(CH2CH = CCl2)2

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1959
1. The condensation of 1,1,3-trichloro-1-propene with benzene, toluene, 3-phenyl-1,1-dichloro-1-propene, 3-(p-chlorophenyl)-1,1-dichloro-1-propene, naphthalene and 3-phenyl-1,1,1,2-tetrachloropropane was carried out in the presence of aluminum chloride or antimony pentachloride, with the formation of the corresponding mono- and di-alkylated products.
R. Kh. Freidlina, N. A. Semenov, A. N. Nesmeyanov   +2 more
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Kinetics of the reaction of the CCl2 biradical with NO

Chemical Physics Letters, 2003
Abstract The kinetics of the of CCl2 with nitric oxide has been studied using the laser photolysis/photoionization mass spectrometry technique. Dichloromethylene biradicals were produced by the pulsed laser photolysis of carbon tetrachloride and the kinetics of their decay due to reaction with NO were monitored in direct time-resolved experiments ...
Alexander A. Shestov, Sofya A. Kostina, Eugene V. Shafir, Irene R. Slagle, Vadim D. Knyazev   +4 more
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CCL2/CCR2 signaling pathway in glioblastoma multiforme

Neurochemistry International, 2017
Glioblastoma multiform (GBM) is described as one of the most frequent primary brain tumors. These types of malignancies constitute only 15% of all primary brain tumors. Despite, extensive developments on effective therapeutic methods during the 20th century as well as the first decade of the present century (21st), the median survival rate for patients
Alireza, Vakilian, Hossein, Khorramdelazad, Parisa, Heidari, Zahra, Sheikh Rezaei, Gholamhossein, Hassanshahi   +4 more
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Alcohol's Effect on the Metabolome and CCL2

The FASEB Journal, 2017
When alcohol enters the central nervous system it disrupts the physiological balance, producing a plethora of negative effects on the nervous system, specifically learning and memory. It has been shown that the neuroimmune protein CCL2 perturbs the negative effects alcohol has on the hippocampus, the region of the brain associated with learning and ...
Calvin Wayne Berndt, Peter Schumann, Alyssa Dunn, Jennifer Bray, Jim Lawrence   +4 more
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