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Simvastatin reduces CCL2 expression in monocyte-derived cells by induction of a repressive CCL2 chromatin state

Human Immunology, 2014
Statins exert anti-inflammatory characteristics, besides their lipid lowering properties, and may display beneficial effects for the treatment of inflammatory diseases. One possible explanation is that statins interfere in the deregulated gene transcription patterns associated with immune-mediated diseases, although the precise mechanism is not fully ...
Zannette, D.L.   +3 more
openaire   +2 more sources

Kinetics of the reaction of the CCl2 biradical with NO

Chemical Physics Letters, 2003
Abstract The kinetics of the of CCl2 with nitric oxide has been studied using the laser photolysis/photoionization mass spectrometry technique. Dichloromethylene biradicals were produced by the pulsed laser photolysis of carbon tetrachloride and the kinetics of their decay due to reaction with NO were monitored in direct time-resolved experiments ...
Alexander A. Shestov   +4 more
openaire   +1 more source

Alcohol's Effect on the Metabolome and CCL2

The FASEB Journal, 2017
When alcohol enters the central nervous system it disrupts the physiological balance, producing a plethora of negative effects on the nervous system, specifically learning and memory. It has been shown that the neuroimmune protein CCL2 perturbs the negative effects alcohol has on the hippocampus, the region of the brain associated with learning and ...
Calvin Wayne Berndt   +4 more
openaire   +1 more source

CCL2/CCR2 signaling pathway in glioblastoma multiforme

Neurochemistry International, 2017
Glioblastoma multiform (GBM) is described as one of the most frequent primary brain tumors. These types of malignancies constitute only 15% of all primary brain tumors. Despite, extensive developments on effective therapeutic methods during the 20th century as well as the first decade of the present century (21st), the median survival rate for patients
Alireza, Vakilian   +4 more
openaire   +2 more sources

Hyperocclusion Stimulates Osteoclastogenesis via CCL2 Expression

Journal of Dental Research, 2011
Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We hypothesized that MS induces expression of osteoclastogenesis-associated chemokines in PDL tissue, resulting in ...
K T, Goto   +6 more
openaire   +2 more sources

Association of CCL2 with systemic inflammation in Schnitzler syndrome

British Journal of Dermatology, 2018
Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal gammopathy, which manifest mostly in the second half of life. It involves overactivation of the interleukin (IL)-1 system, but the exact pathophysiological pathways remain largely unknown.To identify and ...
K. Krause   +6 more
openaire   +2 more sources

The collisional removal of the carbene CCl2(X̃(0,0,0)) and CCl2((0,7,0)) by rare gases and simple molecules

Chemical Physics, 2000
Abstract Absolute rate constants have been measured at room temperature for the collisional removal of dichlorocarbene, CCl 2 , in its X  1 A 1 (0,0,0) ground electronic state by simple alkenes, CF 2 CCl 2 , He and Ar. Rate data for CCl 2 in the first singlet electronically excited state, A  1 B 1 (0,7,0), obtained by time-resolved emission, are ...
I. Merelas   +5 more
openaire   +1 more source

CCL2: An important cytokine in normal and pathological pregnancies: A review

Frontiers in Immunology, 2023
Jun Shao, Jia-Lu Shi
exaly  

CCl2

2006
E. Hirota   +5 more
openaire   +1 more source

CCl2 Dichloromethylene

2005
G. Graner   +6 more
openaire   +1 more source

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