Results 291 to 300 of about 138,616 (334)

Serum Pyroptosis-Related Cytokines as Biomarkers for Diagnostic Assessment and Risk Stratification of Ocular Graft-versus-Host Disease: A Case-Control Study. [PDF]

J Inflamm Res
Lou J, Xu Y, Zhuang X, Zhao Y, Pan H, Chen Y, Zhang X, Lu P.   +7 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Deciphering bisphenol A (BPA)-elicited osteoarthritis mechanisms through network toxicology and molecular docking, then de novo generation of novel therapeutic candidates. [PDF]

BMC Pharmacol Toxicol
Xu S, Jiang L, Zhang Z, Luo X, Wu W, Wu H, Huang Z, Falls Z, Samudrala R, Tan Z.   +9 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Combined exposure to shrimp tropomyosin and microbial components triggers enhanced allergic and inflammatory responses <i>in vitro</i>. [PDF]

Front Allergy
Zegeye FD, Mollerup S, Alswady-Hoff M, Kuehn A, Burla S, Straumfors A, Erdem JS.   +6 more
europepmc   +1 more source

Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation

Small, EarlyView.
This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori, Heela Sarlus, Dick J. Sjöström, Rohith Pavan Parvathaneni, Oommen P. Varghese, Vesa P. Hytönen, Robert A. Harris, Per H. Nilsson, Oommen P. Oommen   +8 more
wiley   +1 more source

Neutrophil extracellular trapping network-associated biomarkers in liver fibrosis: machine learning and experimental validation. [PDF]

J Transl Med
Li Y, Lu Y, Huang B, Lei C, Wu Q, Wang J.   +5 more
europepmc   +1 more source

Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop. [PDF]

Signal Transduct Target Ther
Wang B, Liu J, Wang Q, Arhatte M, Cheong LY, Glogowska E, Jiang X, Chung SK, Jin L, Hu Q, Wang Y, Honoré E, Xu A.   +12 more
europepmc   +1 more source