Results 111 to 120 of about 4,207 (232)

Equatorial waves simulated by the NCAR community climate model [PDF]

The equatorial planetary waves simulated by the NCAR CCM1 general circulation model were investigated in terms of space-time spectral analysis (Kao, 1968; Hayashi, 1971, 1973) and energetic analysis (Hayashi, 1980).
Chen, Tsing-Chang, Cheng, Xinhua
core   +1 more source

The function and regulation of CIA5/CCM1 in Chlamydomonas reinhardtii

, 2018
We demonstrate that CIA5, the master CCM transcription regulator of the Chlamydomonas CCM, has transcription activation activity either in yeast or in Chlamydomonas, and has an acidic activation domain that also is responsible for abnormal SDS-PAGE migration. We are also the first successful overexpression and purification of CIA5 protein from E. coli.,
openaire   +3 more sources

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium

Scientific Reports, 2017
The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM).
Luca Goitre, Peter V. DiStefano, Andrea Moglia, Nicholas Nobiletti, Eva Baldini, Lorenza Trabalzini, Julie Keubel, Eliana Trapani, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Ingrid H. Sarelius, Saverio Francesco Retta, Angela J. Glading   +12 more
doaj   +1 more source

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

A Novel CCM3 Mutation Associated with a Severe Clinical Course in a Child with Multiple Cerebral Cavernous Malformations

Journal of Vascular Diseases
Background: Cerebral cavernous malformations (CCMs) are vascular lesions linked to mutations in the CCM1, CCM2, and CCM3 genes, resulting in angiogenesis dysregulation.
Olga Belousova, Denis Semenov, Eugenia Boulygina, Svetlana Tsygankova, Alexander Konovalov   +4 more
doaj   +1 more source

Monogenic signs of susceptibility to ischemic stroke: literature review

Ukrainian Neurosurgical Journal, 2016
Genetic factors are the important chain in the complex conditions determining the development of ischemic stroke. Mutations have different significance for the risk of its development.
Vitaliy Tsymbaliuk, Iryna Vasileva
doaj   +1 more source

Cloud radiative forcing effects on observed and simulated global energetics [PDF]

The research objectives are the following: (1) to examine how cloud-radiation processes generate/destroy available potential energy by altering both meridional and zonal temperature gradient; (2) to investigate how the atmospheric dynamic fields respond ...
Robertson, Franklin, Sohn, Byung-Ju
core   +1 more source

Novel KRIT1/CCM1 heterozygous nonsense mutation (c.715 C>T) associated with cerebral and cerebellar cavernous malformations in a paediatric patient

BMJ Case Reports, 2018
A 4-year-old Hispanic boy with no significant history presented to the emergency room with 4 days of headache, nausea, vomiting and gait abnormality. Physical exam was significant for cerebellar symptoms.
Dillon Y. Chen, J. Crawford
semanticscholar   +1 more source

Climate dynamics experiments using a GCM simulations [PDF]

The study of surface-atmosphere interactions has begun with studies of the effect of altering the ocean and land boundaries. A ten year simulation of global climate using observed sea surface temperature anomalies has begun using the NCAR Community ...
Christy, John R., Fitzjarrald, Dan, Lu, H.-I., Robertson, Franklin R., Sohn, B., Srikishen, J.   +5 more
core   +1 more source

Global rainfall monitoring by SSM/I [PDF]

Significant accomplishments in the last year of research are presented. During 1991, three main activities were undertaken: (1) development and testing of a preliminary global rainfall algorithm; (2) researching areas of strong surface scattering; and (3)
Barrett, Eric C., Kidd, C., Kniveton, D.
core   +1 more source